TOOSENDANIN

作品数：12被引量：51H指数：5
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相关领域：医药卫生更多>>
相关作者：谢帆崔鹏更多>>
相关机构：合肥工业大学中国药科大学云南中医药大学更多>>
相关期刊：《Chinese Journal of Natural Medicines》《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》《Neural Regeneration Research》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划山西省自然科学基金更多>>
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Toosendanin:upgrade of an old agent in cancer treatment
《Chinese Journal of Natural Medicines》2024年第10期887-899,共13页LI Shuwei XIONG Qingyi SHEN Yiwen LIN Jiayi ZHANG Lijun WU Ye JIN Jinmei LUAN Xin 
supported by the National Natural Science Foundation of China(Nos.82322073,82304790,and 82173846);China Postdoctoral Innovative Talent Support Program(BX20220213);Shanghai Rising-Star Program(No.22QA1409100);Oriental Scholars of Shanghai(No.TP2022081);Jiangxi Province Thousand Talents Program(No.jxsq2023102168);Young Talent Lifting Project of China Association of Chinese Medicine[No.CACM-(2021-QNRC2-A08)];Shanghai Science and Technology Innovation Action Plan(No.21S11902800);Three-year Action Plan for Shanghai TCM Development and Inheritance Program[Nos.ZY(2021-2023)-0401 and ZY(2021-2023)-0208];Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(No.ZYYCXTD-D-202004);CAMS Innovation Fund for Medical Sciences(CIFMS)(No.2023-I2M-3-009);Shanghai Sailing Program(Nos.22YF1445000 and 23YF1442600);the National Key R&D Program of China(No.2022YFC3502000);High-level Key Discipline of National Administration of Traditional Chinese Medicine,Innovation team of high-level local universities in Shanghai:Strategic Innovation Team of TCM Chemical Biology,Organizational Key Research and Development Program of Shanghai University of Traditional Chinese Medicine(No.2023YZZ02)。
Toosendanin(TSN),a tetracyclic triterpenoid derived from Melia toosendan and M.azedarach,demonstrates broad application prospects in cancer treatment.Although previously employed as a pesticide,recent studies have rev...
关键词：TOOSENDANIN Cancer therapy HEPATOTOXICITY PROTAC Nano-delivery systems 
Quercetin attenuates toosendanin-induced hepatotoxicity through inducing the Nrf2/GCL/GSH antioxidant signaling pathway被引量：13
《Acta Pharmacologica Sinica》2019年第1期75-85,共11页Yao Jin Zhen-lin Huang Li Li Yang Yang Chang-hong Wang Zheng-tao Wang Li-li Ji 
the State Major Science and Technology Special Projects during the 12th Five-year Plan (2015ZX09501004-002-002);the National Natural Science Foundation of China (81322053,81573679).
Toosendanin (TSN)is the main active compound in Toosendan Fructus and Meliae Cortex,two commonly used traditional Chinese medicines.TSN has been reported to induce hepatotoxicity,but its mechanism remains unclear.In t...
关键词：QUERCETIN TOOSENDANIN HEPATOTOXICITY NRF2 GSH GCL traditional chinese medicine 
New limonoids isolated from the bark of Melia toosendan被引量：2
《Chinese Journal of Natural Medicines》2018年第12期946-950,共5页ZHANG Qiong ZHENG Qing-Hong SANG Yi-Shu SUNG Herman Ho-Yung MIN Zhi-Da 
supported by National Natural Science Foundation of China(No.31440027);Natural Science Foundation of Shanxi Province,China(No.201601D011123);Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi(No.2014133);Science and Technology Innovation Found of Shanxi Medical University(No.C01201008)
Two new limonoids, 12-ethoxynimbolinins G and H(compounds 1 and 2), and one known compound, toosendanin(Chuanliansu)(compound 3), were isolated from the bark of Melia toosendan. Their structures were elucidated by spe...
关键词：Melia toosendan MELIACEAE LIMONOID TOOSENDANIN ABSOLUTE configuration 
Inhibition of botulinum toxin's association with rat brain synaptosomes by toosendanin,an antibotulismic triterpenoid被引量：3
《Neural Regeneration Research》2006年第6期489-492,共4页Jianying Zhou Yuliang Shi 
the Major State Basic Research Development Program of China (973 pro-gram), No. G1999054000; the National Natural Science Foun-dation of China, No. 30170302;Basic Research Program of Shanghai, No. 02JC14011
BACKGROUND： Toosendanin （TSN）, a tnterpenoid derivative extracted from the bark of Melia toosendanin Sieb et Zucc, has been demonstrated to be an effective drug for treatment of experimental botulism. OBJECTIVE ： ...
Toosendanin interferes with pore formation of botulinum toxin type A in PC12 cell membrane被引量：9
《Acta Pharmacologica Sinica》2006年第1期66-70,共5页Mu-feng LI Yu-liang SHI 
Project supported by the National Basic Research Program of China(No G 1999054000);the National Natural Science Foundation of China(No 30170302);the Basic Research Program of Shanghai(№ 02JC14011).
Aim： Botulinum neurotoxins （BoNT） abort the process of neurotransmitter release at presynaptic motor nerve terminals, causing muscle paralysis, The ability of botulinum toxin to produce its effect is dependent on t...
关键词：TOOSENDANIN botulinum toxin type A ion channel antibotulismic mechanism single channel recording 
Cure of experimental botulism and antibotulismic effect of toosendanin被引量：15
《Acta Pharmacologica Sinica》2004年第6期839-848,共10页Yu-liangSHI Zhong-fengWANG 
Project supported by the National Basic Research Program ofChina(G1999054000);NationalNatural Science Foundation ofChina (30170302; 39870249); and Basic Research Program ofShanghai(02JC14011).
Botulinum neurotoxins (BoNTs), a group of bacterial proteins that comprise a light chain disulfide linked a heavy chain, are the most lethal biotoxins known to mankind. By inhibiting neurotransmitter release, BoNTs c...
关键词：TOOSENDANIN botulinum toxins BOTULISM synaptic transmission NEUROTRANSMITTER TRITERPENE Chinese traditional medicine 
Toosendanin induced continuous increase in Ca^2＋ current in NG108-15 cells
《中国药理通讯》2004年第2期17-17,共1页Mu-FengLi Yu-LiangShi 
Toosendanin (TSN), a triterpenoid derivative from Chinese traditional medicine, is a selective presynaptic blocker and an effective antibotulismic agent. Recently, its apoptosis-initiated effect and cytotoxicity in se...
关键词：川栋素 组胺 NG108-15 细胞增殖 钙元素 大鼠 药理实验 
Toosendanin increases free-Ca^(2+) concentration in NG108-15 cells υia L-type Ca^(2+) channels被引量：8
《Acta Pharmacologica Sinica》2004年第5期597-601,共5页Tong-huiXU junDING Yu-liangSHI 
Project supported by the National Basic Research Program ofChina (No G1999054000); National Natural Science Founda-tion of China (No 39870249 and 30170302); and the Basic Re-search Program (No 02JC14011).
AIM: To examine if toosendanin (TSN) affects intracellular free-Ca2+ concentration ([Ca2+]i) in neuroblastomagliomahybrid cells (NG108-15 cells). METHODS: The [Ca2+]i was determined by laser-scanning confocal microsc...
关键词：TOOSENDANIN intracellular calcium concentration confocal microscopy calcium indicator neuroblastomaglioma hybrid cells L-type Ca2+ channels 
The pre-synaptic blocker toosendanin does not inhibit secretion in exocrine cells被引量：4
《World Journal of Gastroenterology》2002年第5期918-922,共5页Zong-Jie Cui Xue-Hui He Institute of Cell Biology,Beijing Normal University,Beijing 100875,China 
Natural Science Foundation of China Grant No.39870367,39825112,30070286;The Ph.D.Program of the Ministry of Education,China.
AIM：Toosendanin is a pre-synaptic blocer at the neuromuscular junction and its inhititory effect is divided into an initial facilitatve/stimulatory phase followed by a prolonged inhibitory phase,The present study inv...
关键词：川楝素 突触前抑制剂 外分泌细胞 实验研究 
Toosendanin-induced change of dopamine level detected by microdialysis in vivo at rat striatum被引量：10
《Chinese Science Bulletin》1999年第12期1106-1110,共5页Wenyan Chen Pingbo Yin Weiling Ye Yuliang Shi 
To investigate the effect on central nervous transmission of toosendanin (TSN), a presynaptic blocker, rat striatum was perfused in vivo with a TSN-containing artificial cere-brospinal fluid (ACSF) and the level of do...
关键词：PRESYNAPTIC BLOCKER TOOSENDANIN DOPAMINE INTRACEREBRAL MICRODIALYSIS neurotransmitter release. 
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