BLOCKER

作品数：135被引量：390H指数：10
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MicroRNA-155 modulation by renin-angiotensin system inhibitors may underlie their enigmatic role in COVID-19
《World Journal of Experimental Medicine》2025年第2期246-252,共7页Konstantinos I Papadopoulos Alexandra Papadopoulou Tar Choon Aw 
Severe acute respiratory coronavirus-2(SARS-CoV-2)infection course differs between the young and healthy and the elderly with co-morbidities.In the latter a potentially lethal coronavirus disease 2019(COVID-19)cytokin...
关键词：Angiotensin converting enzyme inhibitors Angiotensin II type 1 receptor blocker COVID-19 MicroRNA Mineralocorticosteroid receptor antagonists MicroRNA-155 Renin-angiotensin system inhibitors SARS-CoV-2 Sodium-glucose transporter 2 
From blocker to booster:Harnessing garnet surface chemistry for advanced solid-state electrolytes
《Nano Research》2025年第1期323-331,共9页Jun Cheng Xuan Zhou Hongqiang Zhang Zhen Zeng Yuanyuan Li Yulong Zhu Yingsheng Liao Lijie Ci Deping Li 
supported by National Natural Science Foundation of China(No.52002094);Shenzhen Science and Technology Program(Nos.JCYJ20210324121411031,JSGG202108021253804014 and RCBS20210706092218040);the Shenzhen Steady Support Plan(Nos.GXWD20221030205923001 and GXWD20201230155427003-20200824103000001);State Key Laboratory of Precision Welding&Joining of Materials and Structures(Nos.24-Z-17 and 24-T-08).
Garnet electrolytes with high ionic conductivity and electrochemical stability are widely used as fillers to fabricate composite solid electrolytes(CPEs)within polymer matrices.However,the performance of CPEs is signi...
关键词：garnet electrolyte composite solid electrolyte surface chemistry all-solid-state batteries 
Risks of anti-Helicobacter therapy and long-term therapy with antisecretory drugs
《World Journal of Gastroenterology》2025年第4期1-7,共7页Sergey M Kotelevets 
Helicobacter pylori(H.pylori)infection has a protective effect on gastroesophageal reflux disease(GERD).Both of these diseases have a very high incidence and prevalence.As a result,GERD often recurs after anti-Helicob...
关键词：Epidemiology Gastroesophageal reflux disease Proton pump inhibitor Potassium-competitive acid blocker Risk-benefit GASTROPROTECTION Compensatory mecha-nisms Helicobacter pylori infection Sanogenesis 
The role of angiotensinⅡtype 1 receptor pathway in cerebral ischemia-reperfusion injury:Implications for the neuroprotective effectof ARBs
《Neuroprotection》2024年第2期100-119,共20页Shuhan Huang Meng Zhang 
Chongqing Science and Health Joint Medical ResearchProject,Grant/AwardNumber:2024MSXM124。
Cerebral ischemia-reperfusion(I/R)injury is a crucial factor that impacts the prognosis of recanalization therapy for acute ischemic stroke(AIS).It has been found that the brain renin-angiotensin system,especially the...
关键词：acute ischemic stroke angiotensinⅡtype 1receptor blocker ischemia-reperfusion injury NEUROINFLAMMATION oxidative stress 
β-Receptor blocker enhances the anabolic effect of PTH after osteoporotic fracture被引量：2
《Bone Research》2024年第2期302-313,共12页Jie Huang Tong Wu Yi-Rong Jiang Xuan-Qi Zheng Huan Wang Hao Liu Hong Wang Hui-Jie Leng Dong-Wei Fan Wan-Qiong Yuan Chun-Li Song 
supported by the National Natural Science Foundation of China(Grant Nos.82330078,81874010);the National Key Research and Development Program(Grant Nos.2020YFC2009004,2021YFC2501700).
The autonomic nervous system plays a crucial role in regulating bone metabolism,with sympathetic activation stimulating bone resorption and inhibiting bone formation.We found that fractures lead to increased sympathet...
关键词：BLOCKER METABOLISM inhibited 
Whey protein isolate and kraft lignin multifunctional films for potential food packaging application:UV block and antioxidant potential
《Food Bioscience》2023年第3期1137-1146,共10页Karoline Ferreira Silva Clara Suprani Marques Anderson de Freitas Junior Marali Vilela Dias Fábio Akira Mori 
Research Support Fund(FAPEMIG)for financial assis-tance(grant number 12622);financed in part by the Coordenaçāo de Aperfeiçoamento de Pessoal de Nível Superior-Brasil(CAPES)-Finance code 001.
Kraft lignin(KL)is a promising additive for obtaining multifunctional biodegradable packaging.However,the hydrophobic properties of lignin hinder its dispersion in hydrophilic matrices.The prior alkaline solubilizatio...
关键词：Whey protein isolate Kraft lignin Translucent film Sustainable packaging UV blocker 
Hepatic venous pressure gradient measurement guiding nonselective beta-blocker therapy in a patient with clinically significant portal hypertension
《Portal Hypertension & Cirrhosis》2023年第2期105-108,共4页Kun Wang Minghui Tian Linpeng Zhang Shanghao Liu Xiaoqing Guo Jianzhong Ma 
This study was conducted under the Declaration of Helsinki(revised in 2013).This study was approved by the Institutional Ethics Committee of the Taiyuan Third People's Hospital.
Clinically significant portal hypertension(CSPH),defined as a hepatic venous pressure gradient(HVPG)≥10 mmHg,is an independent risk factor for decompensated events in patients with compensated cirrhosis.Currently,the...
关键词：Hepatic venous pressure gradient Non‐selective beta‐blocker Portal hypertension 
Distribution- and Metabolism-Based Drug Discovery: A Potassium-Competitive Acid Blocker as a Proof of Concept被引量：1
《Research》2022年第4期609-620,共12页Ming-Shu Wang Yi Gong Lin-Sheng Zhuo Xing-Xing Shi Yan-Guang Tian Chang-Kang Huang Wei Huang Guang-Fu Yang 
This work was supported by the National Key Research and Development Program of China(No.2017YFA0505200);the Key Research and Development Program of Hubei Province,China(2020BCB042);the Science and Technology ProgramofWuhan(No.2019020701011460).
Conventional methods of drug design require compromise in the form of side effects to achieve sufficient efficacy because targeting drugs to specific organs remains challenging.Thus,new strategies to design organ-spec...
关键词：DRUGS ORGANS POTASSIUM 
An improved cell line-derived xenograft humanized mouse model for evaluation of PD-1/PD-L1 blocker BMS202-induced immune responses in colorectal cancer被引量：1
《Acta Biochimica et Biophysica Sinica》2022年第10期1497-1506,共10页Pengzhao Shang Liting Yu Shucheng Cao Changying Guo Wanheng Zhang 
supported by the grant from the National Natural Science Foundation of China(No.81773028).
The establishment of an in vivo mouse model mimicking human tumor-immune environments provides a promising platform for immunotherapy assessment,drug discovery and clinical decision guidance.To this end,we construct h...
关键词：BMS202 cancer immunotherapy cell-derived xenograft humanized mouse model PD-1/PD-L1 blocker 
Role of H2 receptor blocker famotidine over the clinical recovery of COVID-19 patients: A randomized controlled trial
《World Journal of Clinical Cases》2022年第23期8170-8185,共16页Abu Taiub Mohammed Mohiuddin Chowdhury Aktar Kamal Md Kafil Uddin Abbas Md Rezaul Karim Md Ahsan Ali Shubhashis Talukder H M Hamidullah Mehedi Hamid Hassan Abul Hossain Shahin Yarui Li Shuixiang He 
the support and cooperation of The First Affiliated Hospital of Xi’an Jiaotong University
BACKGROUND Coronavirus disease 2019(COVID-19)is a global pandemic putting the population at a high risk of infection-related health hazards,mortality and a potential failure of proper medical therapies.Therefore,it is...
关键词：COVID-19 SARS-CoV-2 FAMOTIDINE COVID-19 acute respiratory distress syndrome COVID-19 treatment BANGLADESH 
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