The role of angiotensinⅡtype 1 receptor pathway in cerebral ischemia-reperfusion injury:Implications for the neuroprotective effectof ARBs  

作　　者：Shuhan Huang Meng Zhang 

机构地区：[1]Department of Neurology and Center for Clinical Neuroscience,DapingHospital,Army Medical University,Chongqing,China [2]Department of Neurology,The First Affiliated Hospital of Chongqing Medical University,Chongqing Medical University,Chongqing,China

出　　处：《Neuroprotection》2024年第2期100-119,共20页神经保护（英文）

基　　金：Chongqing Science and Health Joint Medical ResearchProject,Grant/AwardNumber:2024MSXM124。

摘　　要：Cerebral ischemia-reperfusion(I/R)injury is a crucial factor that impacts the prognosis of recanalization therapy for acute ischemic stroke(AIS).It has been found that the brain renin-angiotensin system,especially the angiotensinⅡtype 1 receptor(AT1R)pathway,plays a significant role in cerebral I/R injury.This pathway is involved in processes such as oxidative stress,neuroinflammation,apoptosis,and it affects cerebrovascular autoregulation and the maintenance of blood-brain barrier.AT1R blocker(ARB),widely used as an antihypertensive agent,has demonstrated stroke prevention capabilities in numerous prospective studies,independent of its antihypertensive characteristics.Studies focusing on neurological diseases like Alzheimer's disease,Parkinson's disease,and cognitive impairment have confirmed that ARBs exhibit neuroprotective effects and aid in improving neurological functions.Preclinical studies have shown that ARBs can reduce infarct volume and brain edema,inhibit multiple signaling pathways associated with I/R injury,restore energy levels in damaged brain regions,and rescue the penumbra by promoting neovascularization in cerebral I/R models.These findings suggest that ARBs have potential to become a novel category of neuroprotecting agents for clinical treatment of Als.Therefore,this review primarily provides a theoretical foundation and practical evidence for the future clinical utilization of ARBs as neuroprotective agents following reperfusion therapy for Als.It outlines the role of cerebral I/R injury through the AT1R pathway and highlights the research progressmadeonARBs in I/Rmodels.

关 键 词：acute ischemic stroke angiotensinⅡtype 1receptor blocker ischemia-reperfusion injury NEUROINFLAMMATION oxidative stress 

分 类 号：R743[医药卫生—神经病学与精神病学]