New limonoids isolated from the bark of Melia toosendan  

作　　者：ZHANG Qiong ZHENG Qing-Hong SANG Yi-Shu SUNG Herman Ho-Yung MIN Zhi-Da 

机构地区：[1]Department of Pharmaceutical Science, Shanxi Medical University [2]Department of Natural Medicinal Chemistry, China Pharmaceutical University [3]Department of Chemistry, Hong Kong University of Science and Technology

出　　处：《Chinese Journal of Natural Medicines》2018年第12期946-950,共5页中国天然药物（英文版）

基　　金：supported by National Natural Science Foundation of China(No.31440027);Natural Science Foundation of Shanxi Province,China(No.201601D011123);Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi(No.2014133);Science and Technology Innovation Found of Shanxi Medical University(No.C01201008)

摘　　要：Two new limonoids, 12-ethoxynimbolinins G and H(compounds 1 and 2), and one known compound, toosendanin(Chuanliansu)(compound 3), were isolated from the bark of Melia toosendan. Their structures were elucidated by spectroscopic analysis and X-ray techniques. The absolute configuration of toosendanin(3) was established by single-crystal X-ray diffraction. Compounds 1-3 were evaluated for their cytotoxicity against five tumor cell lines.Two new limonoids, 12-ethoxynimbolinins G and H(compounds 1 and 2), and one known compound, toosendanin(Chuanliansu)(compound 3), were isolated from the bark of Melia toosendan. Their structures were elucidated by spectroscopic analysis and X-ray techniques. The absolute configuration of toosendanin(3) was established by single-crystal X-ray diffraction. Compounds 1-3 were evaluated for their cytotoxicity against five tumor cell lines.

关 键 词：Melia toosendan MELIACEAE LIMONOID TOOSENDANIN ABSOLUTE configuration 

分 类 号：R284.1[医药卫生—中药学]