Summary What is already known about this topic?Foodborne botulism is caused by botulinum neurotoxin(BoNT).Clostridium botulinum(C.botulinum)is a strictly anaerobic,Gram-positive bacterium,which is a key pathogen capab...
funded by the Medical Science Research Project of Hebei Provincial Health and Health Commission(20221073).
BACKGROUND: Early identification of patients requiring ventilator support will be beneficial for the outcomes of botulism. The present study aimed to establish a new scoring system to predict mechanical ventilation(MV...
Intragastric botulismus toxin-A (BoNT-A) is one of the new approaches in the treatment of obesity. We aimed to contribute to the literature by presenting the clinical features, laboratory findings and treatment respon...
Supported by The National Key Research and Development Program of China(2017YFC1601502).
Introduction:Foodborne botulism is a rare,potentially fatal illness resulting from the ingestion of foods contaminated with preformed botulinum neurotoxin types A,B,E,or F,produced by Clostridium botulinum.The descrip...
the National Natural Science Foundation of China(Nos.82173743 and U20A20136).
Botulinum neurotoxins serotype A(BoNT/A)is the deadliest toxins known to humans and the"Category A"agent for bioterrorism.Over the past 20 years,significant efforts have been put forth to develop effective inhibitors ...
Introduction: The differential diagnosis of patients presenting with multiple cranial neuropathies, ataxia, and altered mentation is broad and includes immunologic, infectious, vasculitic and metabolic conditions. Pri...
The geographical distribution of C. botulinum type E and its associated disease, type E botulism in China, is different from that in other areas of the world. Cases of type E botulism generally arise in costal regions...
Botulism is a severe neuroparalytic disease caused by Clostridium botulinums toxins.Although the disease is uncommon,causes great concern due to its high rate of mortality;foodbome outbreaks of botulism occur worldwid...
Project supported by the National Basic Research Program ofChina(G1999054000);NationalNatural Science Foundation ofChina (30170302; 39870249); and Basic Research Program ofShanghai(02JC14011).
Botulinum neurotoxins (BoNTs), a group of bacterial proteins that comprise a light chain disulfide linked a heavy chain, are the most lethal biotoxins known to mankind. By inhibiting neurotransmitter release, BoNTs c...
The epidemiological characteristics and etiology of botulisin in China, as well as the distribution of different types of Clustridium bolulinum in China; are described.Through 1989, 15 provinces and autonomous region...