INHIBITORS

作品数：1258被引量：2684H指数：18
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相关领域：医药卫生更多>>
相关作者：张志丽刘俊义徐萍田超邹晓民更多>>
相关机构：北京大学中国医学科学院北京协和医学院北京化工大学中国科学院更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金国家教育部博士点基金更多>>
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Dual benefits of sodium-glucose cotransporter 2 inhibitors in metabolic diseases: Diabetes control and gout management
《World Journal of Clinical Cases》2025年第14期61-64,共4页Xiao-Peng Fu 
The study by Lin et al delves into the clinical impact of dapagliflozin,a repre-sentative sodium-glucose cotransporter 2(SGLT2)inhibitor,on chronic heart failure complicated by hyperuricemia.This investigation highlig...
关键词：Sodium-glucose cotransporter 2 inhibitors HYPERURICEMIA GOUT Uric acid reduction Chronic heart failure 
Systemic chemotherapy improves outcome of hepatocellular carcinoma patients treated with transarterial chemoembolization
《Hepatobiliary & Pancreatic Diseases International》2025年第2期157-163,共7页Wei-Chen Zhang Ke-Yi Du Song-Feng Yu Xue-E Guo Han-Xi Yu Dong-Yan Wu Cheng Pan Cheng Zhang Jian Wu Li-Fang Bian Lin-Ping Cao Jun Yu 
supported by grants from the National Natural Science Foundation of China(82270682);the Natural Science Foundation of Zhejiang Province(LQ21H030007 and LQ20H30006)。
Background:Transarterial chemoembolization(TACE)based neoadjuvant therapy was proven effective in hepatocellular carcinoma(HCC).Recently,tyrosine kinase inhibitors(TKIs)and immune checkpoint inhibitors(ICIs)also showe...
关键词：Neoadjuvant therapy Hepatocellular carcinoma Major pathologic response Transarterial chemoembolization Tyrosine kinase inhibitors Immune checkpoint inhibitors 
Combining anti-PD-1 antibodies with surufatinib for gastrointestinal neuroendocrine carcinoma: Two cases report and review of literature
《World Journal of Clinical Oncology》2025年第4期298-311,共14页Lou-Lu Gao Dong-Ni Gao Hong-Tu Yuan Wen-Qiang Chen Jing Yang Jie-Qiong Peng 
BACKGROUNDGastrointestinal neuroendocrine carcinoma (GI NEC) has a low incidence rate andpoor prognosis. Most patients already have metastatic disease when they arediagnosed. Platinum chemotherapy is the main means of...
关键词：Gastrointestinal neuroendocrine carcinoma Immune checkpoint inhibitors Angiogenesis inhibitors Combination therapy Case report 
Antidiabetic combination therapy and cardiovascular outcomes:An evidence-based approach
《World Journal of Diabetes》2025年第4期8-18,共11页Vanishri Ganakumar Cornelius J Fernandez Joseph M Pappachan 
Type 2 diabetes mellitus is associated with a 2-4 times increased risk of cardiovascular(CV)disease.Glucagon-like polypeptide-1 receptor agonists(GLP1RA)and sodium-glucose cotransporter-2 inhibitors(SGLT2i)are two imp...
关键词：Glucagon-like polypeptide-1 receptor agonists Sodium-glucose cotransporter-2 inhibitors Cardiovascular disease Type 2 diabetes mellitus Cardiovascular outcome trials 
Efficacy and safety of radiotherapy in patients with microsatellite stable or proficient mismatch repair colorectal cancer liver metastasis
《World Journal of Gastrointestinal Oncology》2025年第3期59-68,共10页Jie Ni Chu-Gen Wan Zi-Qi Sui 
BACKGROUND Colorectal cancer is one of the malignant tumors with a high incidence and mortality rate globally,and the occurrence of liver metastasis significantly affects patient survival prognosis.In recent years,the...
关键词：Microsatellite stability Proficient mismatch repair Colorectal cancer Liver metastasis RADIOTHERAPY Immune checkpoint inhibitors Tyrosine kinase inhibitor Efficacy Safety 
Safety and effectiveness of induction chemoimmunotherapy followed by definitive radiotherapy or concurrent chemoradiotherapy in esophageal squamous cell carcinoma
《World Journal of Clinical Oncology》2025年第3期30-39,共10页Zhuo-Jun Wei Lin Wang Rui-Qi Wang Yu Wang Huan Chen Hong-Lian Ma Yu-Jin Xu 
Supported by Natural Science Foundation of Zhejiang Province,China,No.LGF21H160005;Zhejiang Medical and Health Science and Technology Project,China,No.2024KY049.
BACKGROUND Esophageal squamous cell carcinoma(ESCC)is a common malignancy in China,often diagnosed at an advanced stage,with poor prognosis.Standard treatments such as definitive chemoradiotherapy offer limited surviv...
关键词：Esophageal squamous cell carcinoma RADIOTHERAPY Immune checkpoint inhibitors CHEMOTHERAPY Patient safety Treatment outcome 
Shedding light on the effects of sodium-glucose cotransporter 2 inhibitors in the early stages of heart failure
《World Journal of Cardiology》2025年第3期96-100,共5页Luigi Falco Emilio Di Lorenzo Daniele Masarone 
Heart failure(HF),which falls outside of the historical macrovascular or microvascular categorizations of diabetes complications,has been overlooked for long time in diabetic patients,despite its increasing prevalence...
关键词：Heart failure Sodium-glucose cotransporter 2 Sodium-glucose cotransporter 2 inhibitors Diabetes complications Glycemic control 
DNA Damage Response and Its Inhibitors:Current Perspectives and Future Directions
《中国细胞生物学学报》2025年第3期542-559,共18页ZHENG Xueyi XIE Dan CAI Muyan 
The DDR(DNA damage response)is an essential cellular mechanism that detects and repairs DNA lesions to maintain genomic stability.Dysregulation of DDR pathways is frequently observed in human tumors,leading to increas...
关键词：DNA damage response INHIBITOR BIOMARKER 
Efficacy and Safety of Janus Kinase Inhibitors (JAKi) versus Interleukin 17 Inhibitors (IL-17i) in the Treatment of Active Non-Radiographic Axial Spondyloarthritis (nr-ax SpA), a Comparative Systematized Review
《Open Journal of Rheumatology and Autoimmune Diseases》2025年第1期1-21,共21页Yasir Mohammed Rizwan Rajak 
Background: Non-radiographic axial spondyloarthritis is a progressive and disabling inflammatory disease affecting young adults, with limited treatment options. TNFi are more efficacious than JAKi and IL1-7i in nr-ax ...
关键词：Non-Radiographic Axial Spondyloarthritis nr-ax SPA JAKi Interleukin 17 Inhibitors IL-17i Janus Kinase Inhibitors 
Encrypting Cancer’s Morse Code: The Synergistic Power of CD47-SIRPα Blockade and Tyrosine Kinase Inhibition
《International Journal of Clinical Medicine》2025年第2期135-153,共19页Mahamud Hirsi Yahya Lahrach Abdirahman Mohamud Abdirahman Amina Nazir Mohamed Abshir Barre Yasmine Yusuf Hussein Dinle Abdulrahman Wajih Alkhatib Biradar Rohan Nagendrappa 
Modern medicine faces the formidable challenge of cancer because of its ability to evade immune surveillance and cultivate resistance to conventional therapies. Cancer cells, when overexpressed with CD47, send a “don...
关键词：CD47 Tyrosine Kinase Inhibitors Cancer Immune Evasion Tumor Microenvironment Targeted Cancer Therapy Immune Checkpoint Inhibitors 
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