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作品数：1279被引量：2687H指数：18
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相关领域：医药卫生更多>>
相关作者：张志丽刘俊义徐萍田超邹晓民更多>>
相关机构：北京大学中国医学科学院北京协和医学院北京化工大学中国科学院更多>>
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MicroRNA-155 modulation by renin-angiotensin system inhibitors may underlie their enigmatic role in COVID-19
《World Journal of Experimental Medicine》2025年第2期246-252,共7页Konstantinos I Papadopoulos Alexandra Papadopoulou Tar Choon Aw 
Severe acute respiratory coronavirus-2(SARS-CoV-2)infection course differs between the young and healthy and the elderly with co-morbidities.In the latter a potentially lethal coronavirus disease 2019(COVID-19)cytokin...
关键词：Angiotensin converting enzyme inhibitors Angiotensin II type 1 receptor blocker COVID-19 MicroRNA Mineralocorticosteroid receptor antagonists MicroRNA-155 Renin-angiotensin system inhibitors SARS-CoV-2 Sodium-glucose transporter 2 
Comprehensive analysis of immune subtype characterization on identification of potential cells and drugs to predict response to immune checkpoint inhibitors for hepatocellular carcinoma
《Genes & Diseases》2025年第3期463-477,共15页Guichuan Lai Biao Xie Cong Zhang Xiaoni Zhong Jielian Deng Kangjie Li Hui Liu Yuan Zhang Anbin Liu Yi Liu Jie Fan Tianyi Zhou Wei Wang Ailong Huang 
supported by the Science and Technology Research Programme Project of Chongqing Municipal Education Commission of China(No.KJQN202300423);the National Youth Science Foundation Project(China)(No.82204159);the Science and Technology Project of Sichuan Provincial Administration of Traditional Chinese Medicine(China)(No.2023MS047);the Program for Youth Innovation in Future Medicine,Chongqing Medical University(No.W0150);the Intelligent Medicine Research Project of Chongqing Medical University(No.ZHYX202223).
Immunosubtyping enables the segregation of immune responders from non-responders. However, numerous studies failed to focus on the integration of cellular heterogeneity and immunophenotyping in the prediction of hepat...
关键词：Cellular heterogeneity Drug prediction Hepatocellular carcinoma Immune checkpoint inhibitors Immunosubtyping 
Anemia risk and mitigation strategies in type 2 diabetic patients:The role of novel antidiabetic agents
《World Journal of Diabetes》2025年第5期119-123,共5页Petra Meliš Maja Cigrovski Berkovic 
Anemia is a common yet often overlooked complication in patients with type 2 diabetes mellitus(T2DM),particularly those with chronic kidney disease.It significantly impacts patients'quality of life,cardiovascular heal...
关键词：ANEMIA Type 2 diabetes mellitus chronic kidney disease Iron deficiency METFORMIN Sodium-glucose cotransporter-2 inhibitors Glucagon-like peptide-1 receptor agonist Glucagon-like peptide-1 receptor agonist/GIP dual agonists 
Dual benefits of sodium-glucose cotransporter 2 inhibitors in metabolic diseases: Diabetes control and gout management
《World Journal of Clinical Cases》2025年第14期61-64,共4页Xiao-Peng Fu 
The study by Lin et al delves into the clinical impact of dapagliflozin,a repre-sentative sodium-glucose cotransporter 2(SGLT2)inhibitor,on chronic heart failure complicated by hyperuricemia.This investigation highlig...
关键词：Sodium-glucose cotransporter 2 inhibitors HYPERURICEMIA GOUT Uric acid reduction Chronic heart failure 
Systemic chemotherapy improves outcome of hepatocellular carcinoma patients treated with transarterial chemoembolization
《Hepatobiliary & Pancreatic Diseases International》2025年第2期157-163,共7页Wei-Chen Zhang Ke-Yi Du Song-Feng Yu Xue-E Guo Han-Xi Yu Dong-Yan Wu Cheng Pan Cheng Zhang Jian Wu Li-Fang Bian Lin-Ping Cao Jun Yu 
supported by grants from the National Natural Science Foundation of China(82270682);the Natural Science Foundation of Zhejiang Province(LQ21H030007 and LQ20H30006)。
Background:Transarterial chemoembolization(TACE)based neoadjuvant therapy was proven effective in hepatocellular carcinoma(HCC).Recently,tyrosine kinase inhibitors(TKIs)and immune checkpoint inhibitors(ICIs)also showe...
关键词：Neoadjuvant therapy Hepatocellular carcinoma Major pathologic response Transarterial chemoembolization Tyrosine kinase inhibitors Immune checkpoint inhibitors 
IMPDH inhibitors upregulate PD-L1 in cancer cells without impairing immune checkpoint inhibitor efficacy
《Acta Pharmacologica Sinica》2025年第4期1058-1067,共10页Ming-ming Zheng Jia-yi Li Hong-jie Guo Jie Zhang Long-sheng Wang Ke-fan Jiang Hong-hai Wu Qiao-jun He Ling Ding Bo Yang 
supported by the National Natural Science Foundation of China(No.82330114 to QJH,and No.82273949 to LD).
Tumor cells are characterized by rapid proliferation.In order to provide purines for DNA and RNA synthesis,inosine 5’-monophosphate dehydrogenase(IMPDH),a key enzyme in the de novo guanosine biosynthesis,is highly ex...
关键词：non-small cell lung IMPDH inhibitors PD-L1 mRNA stability HUR immune checkpoint blockade 
Androgen receptor inhibitors in treating prostate cancer
《Asian Journal of Andrology》2025年第2期144-155,共12页Ryan N Cole Qinghua Fang Kanako Matsuoka Zhou Wang 
supported in part by DOD Idea Development Award(HT9425-23-1-0295);NIH grants(R01 CA265897 and R21 CA280467);by the Department of Urology,University of Pittsburgh School of Medicine,Pittsburgh,PA,USA。
Androgens play an important role in prostate cancer development and progression.Androgen action is mediated through the androgen receptor(AR),a ligand-dependent DNA-binding transcription factor.AR is arguably the most...
关键词：androgen receptor ANTI-ANDROGENS prostate cancer 
Immune checkpoint inhibitors plus anti-angiogenesis in patients with resected high-risk hepatitis B virus-associated hepatocellular carcinoma
《World Journal of Gastrointestinal Oncology》2025年第4期116-130,共15页Jian-Lin Lu Yuan Cheng Zi-Ling Xu Gui-Xiang Qian Ming-Tong Wei Wei-Dong Jia 
Supported by the Key Research and Development Projects of Anhui Province,No.202104j07020048;National Key Research and Development Program of China,No.2022YFA1304500.
BACKGROUND Currently,there is a lack of effective adjuvant therapies for patients at high-risk of recurrent hepatitis B virus-associated hepatocellular carcinoma(HBV-HCC)after radical resection.Given the efficacy of a...
关键词：Hepatocellular carcinoma Hepatitis B virus Postoperative adjuvant therapy Immune checkpoint inhibitors ANTIANGIOGENESIS 
Quadruple therapy with immunotherapy and chemotherapy as firstline conversion treatment for unresectable advanced gastric adenocarcinoma: A case report
《World Journal of Gastrointestinal Oncology》2025年第4期503-514,共12页Xiao-Yu Du Ren-Jie Xia Li-Wen Shen Jian-Guo Ma Wei-Qing Yao Wei Xu Zhi-Peng Lin Liang-Bin Ma Guo-Qiang Niu Rui-Fang Fan Shu-Mei Xu Long Yan 
Supported by the Health Industry Research Program of Gansu Province,No.GSWSKY2021-043;the Youth Science and Technology Foundation of Gansu Province,No.22JR11RA002;the Natural Science Foundation of Gansu Province,No.22JR5RA008.
BACKGROUND The treatment of gastric cancer remains highly challenging,particularly in cases of unresectable locally advanced or metastatic disease.Although chemotherapy and immunotherapy have shown some efficacy in su...
关键词：Unresectable locally advanced gastric adenocarcinoma Conversion therapy IMMUNOTHERAPY Programmed cell death protein 1 inhibitors Sintilimab Case report 
Combining immune checkpoint inhibitors with standard treatment regimens in advanced human epidermal growth factor receptor-2 positive gastric cancer patients
《World Journal of Gastrointestinal Oncology》2025年第4期243-253,共11页Sheng-Hu Zhang Wan Li Xi-Yan Chen Le-Le Nie 
This study was approved by the ethics committee of the First People’s Hospital of Fuzhou City(No.FZ202103).
BACKGROUND Gastric cancer is one of the most common malignant tumors worldwide,with its incidence and mortality rates ranking among the highest in gastrointestinal cancers.The overexpression or gene amplification of h...
关键词：ADVANCED Human epidermal growth factor receptor 2-positive Gastric cancer Standard treatment regimen Immune checkpoint inhibitors Efficacy Safety Prognosis Influencing factors 
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