ANTIANGIOGENESIS

作品数：32被引量：144H指数：6
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相关领域：医药卫生生物学更多>>
相关作者：吴旭更多>>
相关机构：中南大学浙江省人民医院更多>>
相关期刊：《Hepatobiliary & Pancreatic Diseases International》《Chinese Medical Journal》《Holistic Integrative Oncology》《Aggregate》更多>>
相关基金：国家自然科学基金国家高技术研究发展计划国家重点基础研究发展计划中国博士后科学基金更多>>
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Antiangiogenic therapy:how far is it to upgrade?
《Holistic Integrative Oncology》2024年第1期549-553,共5页Jing Wang Kai Li 
Early vascular-targeted drugs represented by VEGF single-pathway inhibitors pioneered the idea of regulating the tumor growth microenvironment and enhanced the chemotherapy effect in a variety of tumors.However,their ...
关键词：ANTIANGIOGENESIS MICROENVIRONMENT VEGF Bevascizumab Aolotinib PD-L1 
Dual neovascular targets of vascular endothelial growth factor receptors and platelet-derived growth factor receptor ameliorate thioacetamide induced liver fibrosis in rats
《Portal Hypertension & Cirrhosis》2024年第1期1-13,共13页Bin Xiong Yaowei Bai Jiacheng Liu Tongqiang Li Yingliang Wang Chen Zhou 
National Natural Science Foundation of China,Grant/Award Number:81873917。
Aims:Neovascularization plays a crucial role in liver fibrosis(LF),and blocking vascular endothelial growth factor receptors(VEGFR)has been shown to improve fibrosis.The aim of our study was to investigate the role of...
关键词：ANTIANGIOGENESIS apatinib donafenib FIBROSIS 
Fabrication of microwave-sensitized nanospheres of covalent organic framework with apatinib for tumor therapy被引量：1
《Chinese Chemical Letters》2023年第5期427-432,共6页Qijun Du Jian Zou Zhongbing Huang Shimei Li Longfei Tan Xiangling Ren Guangfu Yin Yongfa Zheng Xianwei Meng 
supported by the National Key Research and Development Program of China(No.2018YFC1106800);National Natural Science Foundation of China(No.81703035);Sichuan Science&Technology Program(No.2020YFSY0018)。
A new nanocomposite of hollow covalent organic framework(COF)conjugated with the apatinib(AP)and loading microwave-sensitizer(ionic liquid,IL)was prepared by layer by layer(LBL)method and hyaluronic acid(HA)coating,na...
关键词：Covalent organic framework ANTIANGIOGENESIS Tumor therapy Microwave hyperthermia Hollow spheres 
First line anlotinib plus liposomal doxorubicin for locally advanced or metastatic soft tissue sarcoma:A prospective,single-arm trial被引量：4
《Asian Pacific Journal of Tropical Medicine》2022年第6期266-273,共8页Xin Sun Ranxin Zhang Jie Xu Lu Xie Wei Guo 
Objective:To examine the efficacy and safety of anlotinib as first-line therapy to treat locally advanced or metastatic soft-tissue sarcoma.Methods:This is a single-arm trial.Treatment-naïve patients(≥14 years)with l...
关键词：Soft-tissue sarcoma Multikinase inhibitor Anlotinib ANTIANGIOGENESIS Liposomal doxorubicin Progression-free survival 
Improving antitumor immunity using antiangiogenic agents:Mechanistic insights,current progress,and clinical challenges被引量：8
《Cancer Communications》2021年第9期830-850,共21页Shu-Jin Li Jia-Xian Chen Zhi-Jun Sun 
National Key Research and Development Program,Grant/Award Number:2017YFSF090107;National Natural Science Foundation of China,Grant/Award Numbers:82072996,81874131;Hubei Province Natural Science Funds for Distinguished Young Scholar,Grant/Award Number:2017CFA062;Innovative research team of high-level local universities in Shanghai,Grant/Award Number:ZLCX20180500。
Cancer immunotherapy,especially immune checkpoint blockade(ICB),has revolutionized oncology.However,only a limited number of patients benefit from immunotherapy,and some cancers that initially respond to immunotherapy...
关键词：ANTIANGIOGENESIS BEVACIZUMAB cancer combination therapy immune-checkpoint inhibitor IMMUNOTHERAPY vascular endothelial growth factor 
Ultrasound activatable antiangiogenic sonosensitizer for VEGFR associated glioblastoma tumor models
《Aggregate》2021年第4期137-143,共7页Subin Son Chuangli Zhang Miae Won Paramesh Jangili Minhyeok Choi Jiasheng Wu Jong Seung Kim 
National Research Foundation ofKorea,Grant/Award Numbers:2018R1A3B1052702,2019M3E5D1A01068998;Basic Science Research Program,Grant/Award Number:2020R1A6A3A01100551;Ministry ofEducation,andNationalNatural Science Foundation of China,Grant/Award Number:21673265。
Angiogenic signaling pathway is a major contributing factor in cancer recurrence and progression,which can cause significantly reduced treatment outcomes,especially in the oxygen-dependent photo-and sonodynamic therap...
关键词：ANTIANGIOGENESIS GLIOBLASTOMA sonodynamic therapy VEGFR blockage 
The relationship between treatment-induced hypertension and efficacy of anlotinib in recurrent or metastatic esophageal squamous cell carcinoma被引量：1
《Cancer Biology & Medicine》2021年第2期562-568,共7页Yan Song Juxiang Xiao Wentao Fang Ping Lu Qingxia Fan Yongqian Shu Jifeng Feng Shu Zhang Yi Ba Yang Zhao Ying Liu Chunmei Bai Yuxian Bai Yong Tang Jie He Jing Huang 
funded by the Chia Tai Tianqing Pharmaceutical Group Co,Ltd.
Objective:In this post-hoc analysis,we evaluated anlotinib treatment-induced hypertension as a potential predictive factor of efficacy in esophageal squamous cell carcinoma(ESCC)patients.Methods:A total of 109 patient...
关键词：Esophageal squamous cell carcinoma(ESCC) anlotinib treatment-induced hypertension prognostic predictor ANTIANGIOGENESIS 
Manipulation of immune-vascular crosstalk:new strategies towards cancer treatment被引量：12
《Acta Pharmaceutica Sinica B》2020年第11期2018-2036,共19页Yang Zhao Xiangrong Yu Jia Li 
Tumor vasculature is characterized by aberrant structure and function,resulting in immune suppressive profiles of tumor microenvironment through limiting immune cell infiltration into tumors,endogenous immune surveill...
关键词：Immune-vascular crosstalk Vascular normalization Nanoparticles TRANSCYTOSIS Immune cells ANTIANGIOGENESIS IMMUNOTHERAPY Tumor microenvironment 
Melatonin: A Powerful Integrative Adjunctive Agent for Oncology
《Journal of Cancer Therapy》2020年第9期571-596,共26页Robert Schettig Trevor Sears Matthew Klein Ruth Tan-Lim Ronald Matthias Christopher Aussems Michael Hummel Rory Sears Zachary Poteet Daniel Warren John Oertle Connor Coffin Dino Prato 
Melatonin is an established hormone supplement and has been well recognized for its effect on the circadian cycle to improve sleep, REM (rapid eye movement), and aiding in jetlag recovery. The utility of melatonin ext...
关键词：MELATONIN ONCOLOGY Immunotherapy Chronic Inflammation Autoimmune Envita Antioxidant Anticancer ANTIANGIOGENESIS TELOMERASE Metastasis ANTI-PROLIFERATION Pro-Apoptosis Immune System Activation Cancer Adjuvant Chemotherapy Synergy 
Discovery of a highly selective VEGFR2 kinase inhibitor CHMFL-VEGFR2-002 as a novel antiangiogenesis agent被引量：6
《Acta Pharmaceutica Sinica B》2020年第3期488-497,共10页Zongru Jiang Li Wang Xuesong Liu Cheng Chen Beilei Wang Wenliang Wang Chen Hu Kailin Yu Ziping Qi Qingwang Liu Aoli Wang Jing Liu Guangchen Hong Wenchao Wang Qingsong Liu 
supported by the National Natural Science Foundation of China(Grant Nos.81773777,81673469,81603123,81803366);the China Postdoctoral Science Foundation(Grant Nos.2018T110634,2018M630720);the Anhui Province Postdoctoral Science Foundation(Grant No.2018B279);the CASHIPS Director’s Fund(Grant No.BJPY2019A03);the Key Program of 13th five-year plan,CASHIPS(Grant No.KP-2017-26).
Angiogenesis is an essential process in tumor growth,invasion and metastasis.VEGF receptor 2(VEGFR2)inhibitors targeting tumor angiogenic pathway have been widely used in the clinical cancer treatment.However,most of ...
关键词：Cancer VEGFR2 KINASE KINASE INHIBITOR ANGIOGENESIS INHIBITOR SELECTIVITY 
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