ANTI-PROLIFERATION

作品数：30被引量：73H指数：5
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相关领域：医药卫生更多>>
相关作者：郑慧娟更多>>
相关机构：中国中医科学院广安门医院更多>>
相关期刊：《Frontiers in Biology》《Chinese Journal of Natural Medicines》《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划中国博士后科学基金更多>>
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Lunasin peptide promotes lysosome-mitochondrial mediated apoptosis and mitotic termination in MDA-MB-231 cells被引量：1
《Food Science and Human Wellness》2022年第6期1598-1606,共9页Yuqiong Hao Huimin Guo Yechun Hong Xin Fan Yumei Su Xiushi Yang Guixing Ren 
financially supported by the Agricultural Science and Technology Innovation Program[CAAS-ASTIP-2021-ICS]。
Lunasin,a novel bioactive peptide,is well-known for its anti-proliferation activity.However,the mechanism of this effect is still poorly reported.Here,synthesized lunasin was used and its anti-proliferative function w...
关键词：ANTI-PROLIFERATION Transcriptome and proteome analysis Cell apoptosis DNA replication 
5-Demethylnobiletin and its major metabolites:efficient preparation and mechanism of their anti-proliferation activity in HepG2 cells
《Food Science and Human Wellness》2022年第5期1191-1200,共10页Yanping Xin Ting Zheng Man Zhang Ruiqiang Zhang Siyue Zhu Dongli Li Denggao Zhao Yanyan Ma Chi-Tang Ho Qingrong Huang 
5-Demethylnobile tin(5-DMN),a hydroxylated polymethoxyflavone(OH-PMF)identified in aged citrus peels,has demonstrated health benefiting effects in previous studies.5-DMN undergoes biotransformation in vivo,yielding 5,...
关键词：Hydroxylated polymethoxyflavones Chemical synthesis HEPG2 Cell cycle APOPTOSIS 
Essential oil from Saussurea costus inhibits proliferation and migration of Eca109 cells via mitochondrial apoptosis and STAT3 signaling
《Asian Pacific Journal of Tropical Biomedicine》2022年第6期253-261,共9页Xia-Fen Hu Wan-Xin Liu Ren Zhang Wei Zhang Chao Wang Meng Chen Rong Shu Xin-Zhou Yang Qiang Wang 
financially supported by the Scientific Research and Innovation Fund of Wuhan Asia General Hospital (Project No. WAGH-DSE-2022-005);2020 General Planning Fund Project for Humanities and Social Sciences of the Ministry of Education,China (Project No. 20YJA880053);Key Research Project of Philosophy and Social Sciences of Hubei Provincial Department of Education in 2020 (Project No. 20D026);WUST National Defence Pre-research Foundation,China (Project No. GF202003);Hubei Province Key Laboratory of Occupational Hazard Identification and Control,Wuhan University of Science and Technology (Project No. OHIC2020G05);National Undergraduate Innovation and Entrepreneurship Training Project (Project No. JCX201976)
Objective:To investigate the effect and its underlying molecular mechanisms of essential oil from Saussurea costus in esophageal cancer cell line Eca109.Methods:The chemical composition of essential oil from Saussurea...
关键词：Saussurea costus Essential oil Gas chromatography-mass spectrometry Apoptosis Mitochondrial pathway STAT3 Esophageal cancer ANTI-PROLIFERATION Anti-migration ECA109 
GKK1032B from endophytic Penicillium citrinum induces the apoptosis of human osteosarcoma MG63 cells through caspase pathway activation被引量：1
《Chinese Journal of Natural Medicines》2022年第1期67-73,共7页LIU Na SONG Mei-Na ZHANG Qian-Qian WU Cong ZHU Kong-Kai SUN Yu-Lin LI Meng-Ru YANG Feng-Ying FENG Run-Liang ZHANG Yu-Ying ZHANG Hua 
the National Natural Science Foundation of China(Nos.82073728 and 31501104);the Natural Science Foundation of Shandong Province(Nos.ZR2019QH006 and JQ201721);the Project of Shandong Province Higher Educational Science and Technology Program(No.J17KA228);the Innovation Team Project of Jinan Science&Technology Bureau(No.2018GXRC003);the Young Taishan Scholars Program(No.tsqn20161037);Shandong Talents Team Cultivation Plan of University Preponderant Discipline(No.10027).
Chemical investigation of the culture extract of an endophytic Penicillium citrinum from Dendrobium officinale,afforded nine citrinin derivatives(1–9)and one peptide-polyketide hybrid GKK1032B(10).The structures of t...
关键词：Penicillium citrinum ENDOPHYTIC GKK1032B ANTI-PROLIFERATION APOPTOSIS 
Phylogenetic analysis and protective effects of thymol and its chromatographic fractions from a novel wild mushroom in combating oxidative stress被引量：2
《Food Science and Human Wellness》2021年第4期452-459,共8页M.Subbulakshmi Sugapriya Dhanasekaran S.Abirami M.Kannan R.Palaniappan Divya Venugopal 
Mushrooms are good sources of phytochemicals that have antioxidant and anti-proliferative effects.This study identifi ed a unique isoform of 18S rRNA gene(864 bp)from a novel wild mushroom(SMK-1)(GenBank accession num...
关键词：Antioxidant ANTI-PROLIFERATION Dietary mushrooms HeLa cells Novel Mushrooms THYMOL 
Formulating etoposide in a nanoemulsion containing polyunsaturated fatty acids potentiates its anti-proliferation and anti-invasion activities against the ovarian cancer cells
《BIOCELL》2021年第3期695-703,共9页MAYSON H.ALKHATIB SALWA M.AL-HASHEMI HANA M.GASHLAN 
supported by the Deanship of Scientific Research(DSR),King Abdulaziz University,Jeddah,under Grant No.DF-606-247-1441.
Inorporation of etoposide(ETP)into nanoemulsion(NE)containing polyunsaturated faty adids(PUFAS)may potentially augment its antiproliferation efet on the cancer cll The current study aimed to examine the in vitro antit...
关键词：Black currant seed oil Organic evening primrose oil Chemotherapeutic agent Cellular growth Apoptosis 
Multi-omics approaches identify SF3B3 and SIRT3 as candidate autophagic regulators and druggable targets in invasive breast carcinoma被引量：6
《Acta Pharmaceutica Sinica B》2021年第5期1227-1245,共19页Shouyue Zhang Jin Zhang Yang An Xiaoxi Zeng Ziyi Qin Yuqian Zhao Heng Xu Bo Liu 
supported by grants from National Science and Technology Major Project of the Ministry of Science and Technology of the People’s Republic of China(No.2018ZX09735005);National Natural Science Foundation of China(Grant Nos.81522028,81673452,81673455,81873939,81803365 and 81602953);Post-Doctor Research Project(2018M643510,China);Post-Doctor Research Project of West China Hospital,Sichuan University(Grant No.2018HXBH065,China);supported by the grant from“The Recruitment Program of Global Young Experts”(known as“the Thousand Young Talents Plan”,China)。
Autophagy is a critical cellular homeostatic mechanism,and its dysfunction is linked to invasive breast carcinoma(BRCA).Recently,several omics methods have been applied to explore autophagic regulators in BRCA;however...
关键词：Invasive breast carcinoma Multi-omics approach SIRT3 SF3B3 Autophagic regulator ANTI-PROLIFERATION Migration Druggable target 
Phenolic extract of Morchella angusticeps peck inhibited the proliferation of HepG2 cells in vitro by inducing the signal transduction pathway of p38/MAPK被引量：3
《Journal of Integrative Agriculture》2020年第11期2829-2838,共10页LI Fu-hua ZHENG Shao-jie ZHAO Ji-chun LIAO Xia WU Su-rui MING Jian 
This research was supported by the National Natural Science Foundation of China(31471576,31271825);the Fundamental Research Funds for the Central Universities,China(XDJK2018B030,SWU118012).
Morchella angusticeps Peck,one of the most popular edible mushrooms,has attracted great attention due to its delicious taste and healthy properties.However,both its biological effects and the possible mechanism of act...
关键词：Morchella angusticeps Peck phenolic extract cell cycle apoptosis ANTI-PROLIFERATION 
Anti-proliferation and apoptosis-inducing effects of sodium aescinate on retinoblastoma Y79 cells被引量：3
《International Journal of Ophthalmology(English edition)》2020年第10期1546-1553,共8页Lei Li Bing Xu Cai-Rui Li Miao-Miao Zhang Sheng-Jun Wu Wen-Jun Dang Jing-Chen Liu Shu-Guang Sun Wei Zhao 
Supported by the National Natural Science Foundation of China(No.81260153);Scientific Research Fund Project of Yunnan Education Department,China(No.2019Y0278)。
AIM:To investigate the anti-proliferation and apoptosisinducing effects of sodium aescinate(SA)on retinoblastoma Y79 cells and its mechanism.METHODS:Y79 cells were cultured at different drug concentrations for differe...
关键词：sodium aescinate RETINOBLASTOMA intrinsic apoptosis pathway extrinsic apoptosis pathway cell cycle arrest 
Melatonin: A Powerful Integrative Adjunctive Agent for Oncology
《Journal of Cancer Therapy》2020年第9期571-596,共26页Robert Schettig Trevor Sears Matthew Klein Ruth Tan-Lim Ronald Matthias Christopher Aussems Michael Hummel Rory Sears Zachary Poteet Daniel Warren John Oertle Connor Coffin Dino Prato 
Melatonin is an established hormone supplement and has been well recognized for its effect on the circadian cycle to improve sleep, REM (rapid eye movement), and aiding in jetlag recovery. The utility of melatonin ext...
关键词：MELATONIN ONCOLOGY Immunotherapy Chronic Inflammation Autoimmune Envita Antioxidant Anticancer ANTIANGIOGENESIS TELOMERASE Metastasis ANTI-PROLIFERATION Pro-Apoptosis Immune System Activation Cancer Adjuvant Chemotherapy Synergy 
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