Manipulation of immune-vascular crosstalk:new strategies towards cancer treatment  

作　　者：Yang Zhao Xiangrong Yu Jia Li 

机构地区：[1]Centre for the Endothelium,Vascular Biology Program,Centenary Institute,The University of Sydney,Sydney NSW 2042,Australia [2]Department of Radiology,Zhuhai People’s Hospital,Jinan University,Zhuhai 519000,China [3]Department of Biomedical Sciences,Faculty of Medicine,Health and Human Sciences,Macquarie University,Sydney NSW 2109,Australia

出　　处：《Acta Pharmaceutica Sinica B》2020年第11期2018-2036,共19页药学学报（英文版）

摘　　要：Tumor vasculature is characterized by aberrant structure and function,resulting in immune suppressive profiles of tumor microenvironment through limiting immune cell infiltration into tumors,endogenous immune surveillance and immune cell function.Vascular normalization as a novel therapeutic strategy tends to prune some of the immature blood vessels and fortify the structure and function of the remaining vessels,thus improving immune stimulation and the efficacy of immunotherapy.Interestingly,the presence of"immune-vascular crosstalk"enables the formation of a positive feedback loop between vascular normalization and immune reprogramming,providing the possibility to develop new cancer therapeutic strategies.The applications of nanomedicine in vascular-targeting therapy in cancer have gained increasing attention due to its specific physical and chemical properties.Here,we reviewed the recent advances of effective routes,especially nanomedicine,for normalizing tumor vasculature.We also summarized the development of enhancing nanoparticle-based anticancer drug delivery via the employment of transcytosis and mimicking immune cell extravasation.This review explores the potential to optimize nanomedicine-based therapeutic strategies as an alternative option for cancer treatment.

关 键 词：Immune-vascular crosstalk Vascular normalization Nanoparticles TRANSCYTOSIS Immune cells ANTIANGIOGENESIS IMMUNOTHERAPY Tumor microenvironment 

分 类 号：R730.5[医药卫生—肿瘤]