TYROSINE

作品数：221被引量：510H指数：10
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相关机构：大连医科大学徐州医学院复旦大学广东医学院更多>>
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Blocking the PD-1 signal transduction by occupying the phosphorylated ITSM recognition site of SHP-2
《Science China(Life Sciences)》2025年第1期189-203,共15页Wenjie Li Wenyi Mei Hewei Jiang Jie Wang Xiaoli Li Lina Quan Yanyan Diao Yanni Ma Sisi Fan Zhuwei Xie Mengdie Gong Huan Zhu Dewen Bi Feng Zhang Lei Ma Jian Zhang Yufeng Gao Aris Paschalidis Honghuang Lin Fangfang Liu Kangdong Liu Mingliang Ye Zhenjiang Zhao Yajun Duan Zhuo Chen Yufang Xu Weilie Xiao Shengce Tao Lili Zhu Honglin Li 
supported in part by the National Natural Science Foundation of China (81825020, 82150208, 82260682);the National Key R&D Program of China (2022YFC3400501, 2022YFC3400504);the Shanghai Science and Technology Commission Biomedical Science and Technology Support Special Project (21S11907900, 20S11901000);Project of Yunnan Characteristic Plant Screening and R&D Service CXO Platform (2022YKZY001);sponsored by the National Program for Special Supports of Eminent Professionals;National Program for Support of Top-notch Young Professionals
Targeting the PD-1/PD-L1 axis with small-molecular inhibitors is a promising approach for immunotherapy.Here,we identify a natural pentacyclic triterpenoid,Pygenic Acid A(PA),as a PD-1 signaling inhibitor.PA exerts an...
关键词：pygenic acid A programmed death-1 immunoreceptor tyrosine-based switch motif SH2 domain-containing protein-tyrosine phosphatase-2 target identification site recognition 
Pan-TRK positive uterine sarcoma in immunohistochemistry without neurotrophic tyrosine receptor kinase gene fusions:A case report
《World Journal of Clinical Cases》2025年第2期39-49,共11页Seungmee Lee Yu-Ra Jeon Changmin Shin Sun-Young Kwon Sojin Shin 
Supported by Grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute,funded by the Ministry of Health&Welfare,Republic of Korea,No.RS-2022-KH129889.
BACKGROUND The classification of uterine sarcomas is based on distinctive morphological and immunophenotypic characteristics,increasingly supported by molecular genetic diagnostics.Data on neurotrophic tyrosine recept...
关键词：Uterine sarcoma Cervical sarcoma Neurotrophic tyrosine receptor kinase gene fusion Next generation sequencing Case report 
Electrochemical chemoselective thiocarbamylation of late-stage Tyr-containing drugs and peptides
《Science China Chemistry》2024年第10期3382-3388,共7页Wan-Jie Wei Xin-Yu Wang Hai-Tao Tang Fei-Hu Cui Yun-Qi Wu Ying-Ming Pan 
supported by the Guangxi Science and Technology Base and Talent Project(High level Innovative Talents and Team Training)(Guike AD23026094);the Guangxi Natural Science Foundation of China(2021GXNSFFA220005);the National Natural Science Foundation of China(22161008,22061003);the Innovation and Entrepreneurship Training Programme for University Students(202310602013)。
The synthesis and modification of peptides occupy a unique position in the field of drug development,and the functionalization of amino acids is a valuable strategy as an alternative to peptide modification.Currently,...
关键词：TYROSINE electrochemical radical coupling chemical modification PEPTIDES 
Overcoming EGFR-TKI resistance by targeting the tumor microenvironment被引量：1
《Chinese Medical Journal Pulmonary and Critical Care Medicine》2024年第3期151-161,共11页Jinsong Zhang Natalie Vokes Man Li Jiachen Xu Hua Bai Jie Wang Zhijie Wang Jianjun Zhang 
supported by National Key Research and Development Project(Nos.2022YFC2505004,2022YFC2505000 to Z.W.and J.W.);NSFC special program(No.82241229 to J.W.);the National Youth Talent(to Z.W);CAMS Innovation Fund for Medical Sciences(No.2021-1-I2M-012 to Z.W.);National Natural Sciences Foundation of China(Nos.81871889 and 82072586 to Z.W.)。
Targeted therapy has ushered in a new era of precision medicine for non-small cell lung cancer(NSCLC).Currently,epidermal growth factor receptor(EGFR)-tyrosine kinase inhibitors(TKIs)stand as the recommended first-lin...
关键词：Non-small cell lung cancer Epidermal growth factor receptor Tumor microenvironment Epidermal growth factor receptor-tyrosine kinase inhibitor Drug resistance 
A model to reduce tyrosine crystallization in Chinese fermented soybean curd by adjusting NaCl,ethanol and temperature during fermentation
《Food Quality and Safety》2024年第2期356-368,共13页Jia Deng Lijun Yin Xi Yang Xin Jia 
supported by the National Key Technologies Research and Development Program(No.2021YFD2100102);the Key Research and Development Program of Shandong Province(No.2022CXGC010602),China.
Objectives:White spots,mainly consisting of tyrosine,refer to small white particles that exist on the surface of mature Chinese fermented soybean curd or in the fermentation broth and have affected the appearance of C...
关键词：Chinese fermented soybean curd white spots TYROSINE mathematical modeling 
MicroRNA-298 determines the radio-resistance of colorectal cancer cells by directly targeting human dual-specificity tyrosine(Y)-regulated kinase 1A
《World Journal of Gastrointestinal Oncology》2024年第4期1453-1464,共12页Mei-Zhu Shen Yong Zhang Fang Wu Mei-Zhen Shen Jun-Lin Liang Xiao-Long Zhang Xiao-Jian Liu Xin-Shu Li Ren-Sheng Wang 
This study was reviewed and approved by the Experimental Animal Ethics Committee of the First Affiliated Hospital of Guangxi Medical University(Approval No.2023-E386-01).
BACKGROUND Radiotherapy stands as a promising therapeutic modality for colorectal cancer(CRC);yet,the formidable challenge posed by radio-resistance significantly undermines its efficacy in achieving CRC remission.AIM...
关键词：MicroRNA-298 Human dual-specificity tyrosine(Y)-regulated kinase 1A Colorectal cancer Radio-resistance p53 binding protein 1 
Erratum to:Tyrosine-mediated analog resistive switching for artificial neural networks被引量：1
《Nano Research》2023年第8期11543-11543,共1页Min-Kyu Song Seok Daniel Namgung Hojung Lee Jeong Hyun Yoon Young-Woong Song Kang Hee Cho Yoon-Sik Lee Jong-Seok Lee Ki Tae Nam Jang-Yeon Kwon 
Light-controlled phosphorylation in the TrkA-Y785 site by photosensitive UAAs activates the MAPK/ERK signaling pathway
《BIOCELL》2023年第6期1377-1388,共12页SHU ZHAO SHIXIN YE 
Background:This paper aims to establish a light-controlled phosphorylation detection method at the Y785 site of tropomyosin receptor kinase A(TrkA)receptor in mammalian cells by using genetic code expansion technology...
关键词：Tropomyosin receptor kinase A Genetic code expansion Y785 P-azido-L-phenylalanine Photo-caged tyrosine 
Paradigm shift of chemotherapy and systemic treatment for biliary tract cancer
《World Journal of Gastrointestinal Oncology》2023年第6期959-972,共14页Wattana Leowattana Tawithep Leowattana Pathomthep Leowattana 
Biliary tract cancers(BTC)are frequently identified at late stages and have a poor prognosis due to limited systemic treatment regimens.For more than a decade,the combination of gemcitabine and cis-platin has served a...
关键词：Biliary tract cancers Gemcitabine and cisplatin combination Fibroblast growth factor receptor 2 inhibitors Isocitrate dehydrogenase 1 inhibitors Neurotrophic tyrosine receptor kinase gene fusion inhibitors Immune checkpoint inhibitors Microsatellite instability high Infrigatinib Pemigatinib 
Heterologous production of bioactive xenoacremone analogs in Aspergillus nidulans
《Chinese Journal of Natural Medicines》2023年第6期436-442,共7页LIU Zhiguo LI Wei ZHANG Peng SUN Yi YIN Wen-Bing 
supported by the the National Key Research and Development Program of China(No.2021YFC2300400);the Biological Resources Program,Chinese Academy of Sciences(No.KFJ-BRP-009);the Key Research Program of Frontier Sciences,the Chinese Academy of Sciences(No.ZDBS-LY-SM016).
Tyrosine-decahydrofluorene derivatives are a class of hybrid compounds that integrate the properties of polyketides and nonribosomal peptides.These compounds feature a[6.5.6]tricarbocyclic core and a para-cyclophane e...
关键词：Heterologous expression Xenoacremones Tyrosine-decahydrofluorene PKS-NRPS Natural products 
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