PEPTIDES

作品数：477被引量：796H指数：11
导出分析报告
相关领域：医药卫生更多>>
相关作者：朱毅敏彭师奇黄健张龙辉王国栋更多>>
相关机构：北京大学中国科学院复旦大学医学部更多>>
相关期刊：更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金国家高技术研究发展计划更多>>
-
在结果中检索

检索结果分析

结果分析中...
共 条 记 录，以下是1-10
全选清除导出
参考文献引证文献引用追踪
视图：
排序：
Prevent effects of soybean meal peptides in acute alcoholic liver injury based on gut microbiota and metabolome alteration
《Food Science and Human Wellness》2025年第2期525-535,共11页Jingbo Liu Shengrao Li Qi Yang Siwen Lyu Xuanting Liu Zhiyang Du Xiaomin Shang Ting Zhang 
funded by the National Key R&D Program of China(2022YFD2101002);Jilin Province Science and Technology Youth Talent Support Project(QT202021);Fundamental Research Funds for the Central Universities。
This study investigated the preventive effects of soybean meal peptides(SPs)and their purification peptides(GTYW)on acute alcoholic liver injury.We combined the gut microbiota,metabolites,liver inflammation,and oxidat...
关键词：Soybean meal peptides Acute alcoholic liver injury Gut microbiota METABOLITES 
Tuna dark muscle peptides modulate host iron metabolism in the intestine through the gut microbiota and ameliorate iron deficiency anemia
《Food Science and Human Wellness》2025年第2期729-739,共11页Jiaojiao Han Jiayi Xiong Zhixiang Bai Yang Qin Chenyang Lu Jun Zhou Ye Li Tinghong Ming Zhen Zhang Xiurong Su 
sponsored by the Natural Science Foundation of Zhejiang Province(LQ22D060002 and LTGC23C190001);Fund of State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products(ZS20190105);General Project of Zhejiang Provincial Department of Education(Y202146257);K.C.Wong Magna Fund of Ningbo University。
Iron deficiency anemia(IDA)is a nutritional deficiency disease with a high incidence rate worldwide.Bioactive peptides are safe and effective,have multiple functions and can serve as potential candidates for alleviati...
关键词：Iron deficiency anemia PEPTIDES Gut microbiota Fecal transplantation microbiota 
Mining Bovine Milk Proteins for DPP-4 Inhibitory Peptides Using Machine Learning and Virtual Proteolysis
《Research》2025年第1期410-420,共11页Yiyun Zhang Yiqing Zhu Xin Bao Zijian Dai Qun Shen Liyang Wang Yong Xue 
supported by the National Key Research and Development Project(2018YFE0206300-02).
Dipeptidyl peptidase-IV(DPP-4)enzyme inhibitors are a promising category of diabetes medications.Bioactive peptides,particularly those derived from bovine milk proteins,play crucial roles in inhibiting the DPP-4 enzym...
关键词：DPP inhibitors virtual proteolysis techniquesfive machine learning virtual proteolysis bovine milk proteins bovine milk proteinsplay bioactive peptides 
Cell-autonomous innate immunity by proteasome-derived defence peptides
《四川生理科学杂志》2025年第3期584-584,共1页Karin Goldberg 
For decades,antigen presentation on major histocompatibility complex class I for T cell-mediated immunity has been considered the primary function of proteasome-derived peptides1,2.However,whether the products of prot...
关键词：AUTONOMOUS CONSTITUTIVE MOUNT 
AMHF-TP:Multifunctional therapeutic peptides prediction based on multi-granularity hierarchical features
《Quantitative Biology》2025年第1期127-141,共15页Shouheng Tuo YanLing Zhu Jiangkun Lin Jiewei Jiang 
National Natural Science Foundation of China,Grant/Award Number:62276210;Natural Science Basic Research Program of Shaanxi,Grant/Award Number:2022JM-380。
Multifunctional therapeutic peptides(MFTP)hold immense potential in diverse therapeutic contexts,yet their prediction and identification remain challenging due to the limitations of traditional methodologies,such as e...
关键词：deep learning hypergraph multifunctional therapeutic peptides multi-granularity hierarchical features 
Search for microglia-specific peptides:advances in the discovery toolbox
《Neural Regeneration Research》2025年第2期471-472,共2页Ivan Sarabia Kyle M.Koss 
supported by a Canadian Institutes of Health Institute Fellowship RN409371-430628(to KMK).
Uncontrolled and chronic inflammatory states in the central nervous system(CNS)are the hallmark of neurodegenerative pathology and every injury or stroke-related insult.The key mediators of these neuroinflammatory sta...
关键词：INFLAMMATION PATHOLOGY DEATH 
A matrix metalloproteinase-responsive hydrogel system controls angiogenic peptide release for repair of cerebral ischemia/reperfusion injury
《Neural Regeneration Research》2025年第2期503-517,共15页Qi Liu Jianye Xie Runxue Zhou Jin Deng Weihong Nie Shuwei Sun Haiping Wang Chunying Shi 
supported by the Natural Science Foundation of Shandong Province,No.ZR2023MC168;the National Natural Science Foundation of China,No.31670989;the Key R&D Program of Shandong Province,No.2019GSF107037(all to CS).
Vascular endothelial growth factor and its mimic peptide KLTWQELYQLKYKGI(QK)are widely used as the most potent angiogenic factors for the treatment of multiple ischemic diseases.However,conventional topical drug deliv...
关键词：angiogenesis biomaterial blood-brain barrier cerebral ischemia/reperfusion injury control release drug delivery inflammation QK peptides matrix metalloproteinase-2 NEUROPROTECTION self-assembling nanofiber hydrogel 
Peptide-based strategies for overcoming multidrug-resistance in cancer therapy
《Chinese Chemical Letters》2025年第1期110-118,共9页Xiaofang Luo Ye Wu Xiaokun Zhang Min Tang Feiye Ju Zuodong Qin Gregory J Duns Wei-Dong Zhang Jiang-Jiang Qin Xin Luan 
supported by the Science and Technology Innovation Program of Hunan Province(No.2022RC1168);National Natural Science Foundation of China(Nos.82322073,82173846,82304533);CAMS Innovation Fund for Medical Sciences(CIFMS)(No.2023-I2M-3-009);Key project at central government level:The ability establishment of sustainable use for valuable Chinese medicine resources(No.2060302);China Postdoctoral Science Foundation(No.2021M702215);Oriental Scholars of Shanghai Universities(No.TP2022081);Jiangxi Province Thousand Talents Program(No.jxsq2023102168);Young Talent Lifting Project of China Association of Chinese Medicine(No.CACM-(2021-QNRC2-A08));Shanghai Rising-Star Program(No.22QA1409100);Shanghai Sailing Program(No.22YF1445000);2021 Shanghai Science and Technology Innovation Action Plan(No.21S11902800);Three-year Action Plan for Shanghai TCM Development and Inheritance Program(Nos.ZY(2021-2023)-0208,ZY(2021-2023)-0401);High level Key Discipline of National Administration of Traditional Chinese Medicine(No.71);Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(No.ZYYCXTD-D-202004);Innovation team of high-level local universities in Shanghai:Strategic Innovation Team of TCM Chemical Biology。
Despite ongoing advancements in cancer treatment,the emergence of primary and acquired resistance poses a significant challenge for both traditional chemotherapy and immune checkpoint blockade therapies.The demand for...
关键词：Drug resistance Antitumor peptides Mechanism of action Targeted therapeutics IMMUNOTHERAPY Medicinal chemistry 
Trinuclear gold-catalyzed site-selective alkylation of peptides
《Science China Chemistry》2025年第1期249-256,共8页Qing-Yun Fang Chengyihan Gu Yinghan Chen Wencheng Yan Yong Liang Weipeng Li Chengjian Zhu Jie Han Jin Xie 
the National Key Research and Development Program of China(2021YFC2101900,2022YFA1503200);the National Natural Science Foundation of China(22122103,22101130,22001117,22471121,22271144);the Fundamental Research Funds for the Central Universities(020514380327);the open project of state key laboratory of natural medicines(SKLNMKF202401)for financial support。
Selective modification of peptides has always been a challenging issue.The selective alkylation of peptides can alter the biological activity and physical properties of molecules,and it has gained significant research...
关键词：gold catalysis PEPTIDE ALKYLATION C-C coupling RADICAL 
Identification and the molecular mechanism of novel duck liver-derived anti-inflammatory peptides in lipopolysaccharide-induced RAW264.7 cell model
《Food Science and Human Wellness》2024年第6期3595-3605,共11页Xiankang Fan Laidi Zhang Yangying Sun Changyu Zhou Qiang Xia Lihui Du Zhen Wu Daodong Pan 
supported by the National Key R&D Program of China(2021YFD2100104);Science and Technology Programs of Zhejiang(2019C02085);the Modern Agricultural Technical Foundation of China(CARS-42-25).
In this study,10 novel anti-inflammatory peptides were identified from duck liver,and their molecular mechanism was demonstrated based on machine learning and molecular docking.Using Sephadex G-15 gel chromatography s...
关键词：PEPTIDES Machine learning Molecular docking Infl ammation Liquid chromatography-tandem mass spectrometry 
全选清除导出
共48页<12345678910>
检索报告 对象比较 聚类工具 使用帮助 返回顶部