Tuna dark muscle peptides modulate host iron metabolism in the intestine through the gut microbiota and ameliorate iron deficiency anemia  

作　　者：Jiaojiao Han Jiayi Xiong Zhixiang Bai Yang Qin Chenyang Lu Jun Zhou Ye Li Tinghong Ming Zhen Zhang Xiurong Su 

机构地区：[1]State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products,Ningbo University,Ningbo 315832,China [2]School of Marine Science,Ningbo University,Ningbo 315832,China

出　　处：《Food Science and Human Wellness》2025年第2期729-739,共11页食品科学与人类健康(英文)

基　　金：sponsored by the Natural Science Foundation of Zhejiang Province(LQ22D060002 and LTGC23C190001);Fund of State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products(ZS20190105);General Project of Zhejiang Provincial Department of Education(Y202146257);K.C.Wong Magna Fund of Ningbo University。

摘　　要：Iron deficiency anemia(IDA)is a nutritional deficiency disease with a high incidence rate worldwide.Bioactive peptides are safe and effective,have multiple functions and can serve as potential candidates for alleviating IDA.In this study,the anti-anemia effects of tuna dark muscle peptides were explored in a dietinduced IDA mouse model.The results showed that tuna dark muscle peptides alleviated the IDA phenotype,oxidative stress and iron metabolism.In addition,tuna dark muscle peptides reversed gut microbiota dysbiosis in IDA mice.Furthermore,the transplanted fecal microbiota from tuna dark muscle peptide-treated mice also alleviated IDA symptoms and regulated iron metabolism and the gut microbiota,indicating that the antianemic effects were at least partially mediated by the gut microbiota.Thus,we identified a new and safe prebiotic material to alleviate IDA and provided ideas for the development of peptides.At the same time,these data also provided a theoretical basis for fecal microbiota transplantation to alleviate IDA.

关 键 词：Iron deficiency anemia PEPTIDES Gut microbiota Fecal transplantation microbiota 

分 类 号：R55[医药卫生—血液循环系统疾病]