Distinct neuroanatomic subtypes in antipsychotic-treated patients with schizophrenia classified by the predefined classification in a never-treated sample  

作　　者：Qiannan Zhao Jiao Li Yuan Xiao Hengyi Cao Xiao Wang Wenjing Zhang Siyi Li Wei Liao Qiyong Gong Su Lui 

机构地区：[1]Huaxi MR Research Center(HMRRC),Department of Radiology,West China Hospital of Sichuan University,Chengdu 610041,China [2]Research Unit of Psychoradiology,Chinese Academy of Medical Sciences,Chengdu 610041,China [3]Functional and Molecular Imaging Key Laboratory of Sichuan Province,West China Hospital of Sichuan University,Chengdu 610041,China [4]The Clinical Hospital of Chengdu Brain Science Institute,School of Life Science and Technology,University of Electronic Science and Technology of China,Chengdu 610054,China [5]MOE Key Lab for Neuroinformation,High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province,University of Electronic Science and Technology of China,Chengdu 610054,China [6]Center for Psychiatric Neuroscience,Feinstein Institute for Medical Research,Manhasset,NY 11030,United States [7]Division of Psychiatry Research,Zucker Hillside Hospital,Glen Oaks,NY 11004,United States

出　　处：《Psychoradiology》2021年第4期212-224,共13页精神影像学（英文）

基　　金：supported by the National Natural Science Foundation of China[Grant Nos.82120108014(to S.L.),82071908(to S.L.),81671664(to S.L.),81621003(to Q.G.),81820108018(to Q.G.),and 81901705(to Y.X.)];the US-China joint grant[Grant Nos NSFC81761128023(to Q.G.),R01MH112189-01(to Q.G.)];1.3.5 project for disciplines of excellence,West China Hospital,Sichuan University[Project Nos.ZYYC08001(to S.L.)and ZYJC18020(to S.L.)];Sichuan Science and Technology Program[Grant Nos.2021JDTD0002(to S.L.)and 2020YFS0116(to Y.X.)];China Postdoctoral Science Foundation[Grant No.2019M663513(to Y.X.)];the Postdoctoral Interdisciplinary Research Project of Sichuan University[Grant No.0040204153082(to Y.X.)];S.L.acknowledges support from Humboldt Foundation Research Awards and Chang Jiang Scholars(Program No.T2019069).

摘　　要：Background:Distinct neuroanatomic subtypes have been identified in never-treated patients with schizophrenia based on cerebral structural abnormalities,but whether antipsychotic-treated patients would be stratified under the guidance of such previously formed classification remains unclear.Objective:The present study aimed to investigate alterations of brain structures in antipsychotic-treated patients with schizophrenia based on a predefined morphological classification and their relationships with cognitive performance.Methods:Cortical thickness,surface area,and subcortical volume were extracted from 147 antipsychotictreated patients with schizophrenia using structural magnetic resonance imaging for classification.The Brief Assessment of Cognition in Schizophrenia(BACS)and Positive and Negative Syndrome Scale(PANSS)were used to assess cognition and symptoms.Results:Antipsychotic-treated patients were categorized into three subtypes with distinct patterns of brain morphological alterations.Subtypes 1 and 2 were characterized by widespread deficits in cortical thickness but relatively limited deficits in surface area.In contrast,subtype 3 demonstrated cortical thickening mainly in parietal-occipital regions and widespread deficits in surface area.All three subgroups demonstrated cognitive deficits compared with healthy controls.Significant associations between neuroanatomic and cognitive abnormalitieswere only observed in subtype 1,where cortical thinning in the left lingual gyruswas conversely related to symbol coding performance.Conclusions:Similar to drug-naıve patients,neuroanatomic heterogeneity exists in antipsychotic-treated patients,with disparate associations with cognition.These findings promote our understanding of relationships between neuroanatomic abnormalities and cognitive performance in the context of heterogeneity.Moreover,these results suggest that neurobiological heterogeneity needs to be considered in cognitive research in schizophrenia.

关 键 词：SCHIZOPHRENIA neuroanatomic heterogeneity psychoradiology cognitive function antipsychotic medication 

分 类 号：R73[医药卫生—肿瘤]