PEROXYNITRITE

作品数：43被引量：104H指数：7
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相关领域：医药卫生更多>>
相关作者：宋莎莎李建峰万小娟李林鞠远荣更多>>
相关机构：山东大学学研究院首都医科大学滨州医学院更多>>
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相关基金：国家自然科学基金国家教育部博士点基金北京市自然科学基金安徽省自然科学基金更多>>
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“Three-in-one” strategy of trifluoromethyl regulated blood-brain barrier permeable fluorescent probe for peroxynitrite and antiepileptic evaluation of edaravone
《Chinese Chemical Letters》2024年第10期360-363,共4页Lei Shen Hongmei Liu Ming Jin Jinchao Zhang Caixia Yin Shuxiang Wang Yutao Yang 
supported by the National Natural Science Foundation of China(Nos.22177025,21807021,22325703,22177026);Science Fund for Creative Research Groups of Nature Science Foundation of Hebei Province(No.B2021201038);the Interdisciplinary Research Program of Natural Science of Hebei University(No.DXK202113);the Central Government Guided Local Science,Technology Development Fund(Hebei Province,No.216Z2603G);National High-End Foreign Expert Recruitment Plan(No.G2022003007L)。
Epilepsy,as a chronic neurological disease of the brain,is closely related to oxidative stress,and the peroxynitrite(ONOO-)significantly rise up in this event.Therefore,ONOO-is considered as a potential biomarker for ...
关键词：Fluorescent probe Blood-brain barrier PEROXYNITRITE EPILEPSY Drug repurposing 
Regulatory role of peroxynitrite in advanced glycation end products mediated diabetic cardiovascular complications
《World Journal of Diabetes》2024年第3期572-574,共3页Asis Bala 
The Advanced Glycation End Products(AGE)binding with its receptor can increase reactive oxygen species(ROS)generation through specific signaling mediators.The effect of superoxide(O2-)and O2-mediated ROS and reactive ...
关键词：DIABETES Cardiovascular complication Advanced glycation end products Reactive oxygen species Reactive nitrogen species PEROXYNITRITE 
A highly sensitive fluorescent probe RN-NA reveals peroxynitrite as a novel biomarker for primary open angle glaucoma
《International Journal of Ophthalmology(English edition)》2024年第2期219-227,共9页Bo Qin Yuan Lei Luo Bao You-Jia Zhang Ke-Yin Liu Yu-Hong Chen 
Supported by the National Natural Science Foundation of China(No.81870692,No.82070959,No.82271082);the Shanghai Committee of Science and Technology,China(No.20S31905800);Clinical Research Plan of SHDC(No.SHDC2020CR6029).
AIM:To directly quantify peroxynitrite(ONOO-)using a highly sensitive fluorescence resonance energy transfer probe RN-NA,investigate the association between ONOOand primary open angle glaucoma(POAG),and clarify whethe...
关键词：PEROXYNITRITE fluorescent probe RN-NA primary open angle glaucoma 3-morpholinosyndnomine 
Mitochondria-specific near-infrared photoactivation of peroxynitrite upconversion luminescent nanogenerator for precision cancer gas therapy
《Acta Pharmaceutica Sinica B》2024年第1期378-391,共14页Hui Yu Aliya Tiemuer Xufeng Yao Mingyuan Zuo Hai-Yan Wang Yi Liu Xiaoyuan Chen 
This work was financially supported by the National Natural Science Foundation of China(82272148,China);the“Double First-Class”University Project(CPUQNJC22-03,China);the Jiangsu Funding Program for Excellent Postdoctoral Talent(2022ZB301,China);the National University of Singapore(NUHSRO/2020/133/Startup/08,NUHSRO/2023/008/NUSMed/TCE/LOA,NUHSRO/2021/034/TRP/09/Nanomedicine);National Medical Research Council(MOH-OFIRG23jan-0005,CG21APR1005);Singapore Ministry of Education(MOE-000387-00);National Research Foundation(NRF-000352-00).
Gas therapy is emerging as a highly promising therapeutic strategy for cancer treatment.However,there are limitations,including the lack of targeted subcellular organelle accuracy and spatiotemporal release precision,...
关键词：Near infrared Photo-triggered Mitochondrion Upconversion luminescent bioimaging PEROXYNITRITE NANOGENERATOR Gas therapy In vivo 
An ischemic area-targeting,peroxynitrite-responsive,biomimetic carbon monoxide nanogenerator for preventing myocardial ischemia-reperfusion injury被引量：1
《Bioactive Materials》2023年第10期480-494,共15页Jinyan Zhang Liwei Liu Zhen Dong Xicun Lu Wenxuan Hong Jin Liu Xiaoyi Zou Jinfeng Gao Hao Jiang Xiaolei Sun Kai Hu Youjun Yang Junbo Ge Xiao Luo Aijun Sun 
support by the National Natural Science Foundation of China(81900353,82270264,T2288101,82130010,21908065,22078098,22278138);the National Science Fund for Distinguished Young Scholars(817200010);the Basic research projects of Shanghai Science and Technology Commission(22JC1400500);the Innovation Program of Shanghai Municipal Education Commission.
Myocardial ischemia-reperfusion (MI/R) injury is common in patients who undergo revascularization therapy for myocardial infarction, often leading to cardiac dysfunction. Carbon monoxide (CO) has emerged as a therapeu...
关键词：Ischemia-reperfusion injury Macrophage membrane MITOCHONDRIA Inflammation PEROXYNITRITE 
A novelα-ketoamide reactivity-based two-photon fluorogenic probe for visualizing peroxynitrite in Parkinson's disease models
《Journal of Innovative Optical Health Sciences》2023年第4期79-89,共11页Tao Shao Xianning Xu Lan Wang Yu Shen Jun Zhao Huizi Li Duoteng Zhang Wei Du Hua Bai Bo Peng Lin Li 
supported by the National Natural Science Foundation of China(22077101);the Open Project Program of Wuhan National Laboratory for Optoelectronics(No.2020WNLOKF023);Natural Science Foundation of Shaanxi Province(2022JM-130);the Joint Research Funds of Department of Science&Technology of Shaanxi Province and Northwestern Polytechnical University(2020GXLH-Z-008,2020GXLH-Z-021,2020GXLH-Z-023);the China Postdoctoral Science Foundation(2022M711595,2022M722595);Postdoctoral Research Funding Schemes of Jiangsu Province(2021K036A);The Natural Science Foundation of Ningbo(202003N4049,202003N4065).
Peroxynitrite(ONOO^(-))contributes to oxidative stress and neurodegeneration in Parkinson's disease(PD).Developing a peroxynitrite probe would enable in situ visualization of the overwhelming ONOO^(-)flux and understa...
关键词：α-Ketoamide two-photon fluorogenic probe BIOIMAGING PEROXYNITRITE Parkinson's disease. 
Rationally designed meso-benzimidazole-pyronin with emission wavelength beyond 700 nm enabling in vivo visualization of acute-liver-injury-induced peroxynitrite
《Chinese Chemical Letters》2023年第4期226-230,共5页Minghao Ren Chengyong Zhou Linfang Wang Xin Lv Wei Guo 
Scientific and Technological Innovation Program of Colleges and Universities in Shanxi Province (Nos.2021L529, 2021L530)。
Fluorescent dyes with fluorescence emission above 700 nm are favorable for bio-imaging due to the higher tissue transparency and lower background fluorescence. In this study, we present a mesobenzimidazole-pyronin pla...
关键词：Near infrared fluorescent dyes Lysosome-targetable Fluorescence probe PEROXYNITRITE Acute liver injury 
Flexible electrostatic hydrogels from marine organism for nitric oxide-enhanced photodynamic therapy against multidrug-resistant bacterial infection被引量：1
《Science China Materials》2022年第10期2850-2860,共11页Yujie Sun Rong-Lai Wen Dan Yu Yiwen Zhu Liang Zheng Xiangdong Liu Haoran Wang Bingran Yu Fu-Jian Xu 
supported by the National Key R&D Program of China(2021YFB3800900);the National Natural Science Foundation of China(22122501,21875014 and 52073013);Beijing Outstanding Young Scientist Program(BJJWZYJH01201910010024)。
The abuse of antibiotics in treating microbial infections has led to the emergence and prevalence of drugresistant bacteria.Thus,the development of novel antibacterial materials is attracting increasing attention.Here...
关键词：electrostatic hydrogel drug-resistant bacteria PEROXYNITRITE photodynamic therapy 
Endogenous peroxynitrite activated fluorescent probe for revealing anti-tuberculosis drug induced hepatotoxicity被引量：1
《Chinese Chemical Letters》2022年第3期1584-1588,共5页Nannan Wang Han Wang Jian Zhang Xin Ji Huihui Su Jinying Liu Jiamin Wang Weili Zhao 
financially supported by the National Natural Science Foundation of China (Nos. 82030107 and 21702046);the China Postdoctoral Science Foundation (No. 2018M632757);the Key Scientific and Technological Project of Henan Province (Nos.212102311064 and 212102310870);the Innovation Scientists and Technicians Troop Construction Projects of Henan Province(No. 20IRTSTHN020)。
Py^(+)razinamide (PZA), isoniazid (INH) and rifampicin (RFP) are all commonly used anti-tuberculosis drugs in clinical practice, and long-term medication may cause severe liver damage and toxicity. The level of peroxy...
关键词：Anti-tuberculosis drug induced liver injury PEROXYNITRITE Fluorescent probe Drug-induced liver injury BIOIMAGING 
Engineering of Reversible Luminescent Probes for Real-Time Intravital Imaging of Liver Injury and Repair被引量：1
《CCS Chemistry》2022年第1期356-368,共13页Xiao Liu Linhui He Xiangyang Gong Yue Yang Dan Cheng Juanjuan Peng Lu Wang Xiao-Bing Zhang Lin Yuan 
supported by NSFC(nos.21877029,22074036,21735001);the National Key R&D Program of China(no.2019YFA0210100).
As the major organ for drug metabolism and detoxification,the liver is prone to damage and severely impaired functionality.The treatment of liver diseases is based on a clear understanding of the process underlying li...
关键词：luminescent probes liver injury and repair fluorescence imaging PEROXYNITRITE GSH 
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