Regulatory role of peroxynitrite in advanced glycation end products mediated diabetic cardiovascular complications  

作　　者：Asis Bala 

机构地区：[1]Pharmacology and Drug Discovery Research Laboratory,Division of Life Sciences,Institute of Advanced Study in Science and Technology,Guwahati 781035,Assam,India

出　　处：《World Journal of Diabetes》2024年第3期572-574,共3页世界糖尿病杂志（英文版）（电子版）

摘　　要：The Advanced Glycation End Products(AGE)binding with its receptor can increase reactive oxygen species(ROS)generation through specific signaling mediators.The effect of superoxide(O2-)and O2-mediated ROS and reactive nitrogen species depends on their concentration and location of formation.Nitric oxide(NO)has anti-inflammatory and anticoagulant properties and a vasodilation effect,but NO can be deactivated by reacting with O_(2)^(-).This reaction between NO and O2-produces the potent oxidant ONOO−.Therefore,ONOO-'s regulatory role in AGEs in diabetic cardiovascular complications must considered as a regulator of cardiovascular complications in diabetes.

关 键 词：DIABETES Cardiovascular complication Advanced glycation end products Reactive oxygen species Reactive nitrogen species PEROXYNITRITE 

分 类 号：R587.2[医药卫生—内分泌] R563.1[医药卫生—内科学]