云南高校图书馆联盟文献共享服务平台- PENTYLENETETRAZOLE

PENTYLENETETRAZOLE: 作品数：20被引量：64H指数：4; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：王伟何小华阮旭中李文鑫张梁更多>>; 相关机构：同济医科大学附属同济医院武汉大学浙江大学温州医科大学更多>>; 相关期刊：《Acta Pharmacologica Sinica》《Neural Regeneration Research》《中国药理通讯》《World Journal of Traditional Chinese Medicine》更多>>; 相关基金：国家自然科学基金广东省自然科学基金中国科学院科研项目浙江省自然科学基金更多>>

The Anxiolytic and Antidepressant Effect of Stachys Lavandulifolia in the Experimental Pentylenetetrazole-Induced Rat Model of Acute Seizure: 《World Journal of Traditional Chinese Medicine》2024年第1期114-120,共7页Vahid Azizi Farzin Allahyari Abdolkarim Hosseini; financially supported by Shahid Beheshti University。; Objective:In traditional medicine,Stachys lavandulifolia or mountain tea has been used in the treatment of arthritis and rheumatoid arthritis.A leaf extract from this plant is also thought to be effective in treating ...; 关键词：ANXIETY behavior depression oxidative stress traditional medicine

Sericin alleviates pentylenetetrazole kindling epilepsy and associated comorbidities via modulation of GABA-T enzyme and mitochondrial activity: 《Asian Pacific Journal of Tropical Biomedicine》2023年第10期431-442,共12页Sania Grover Raj Kumar Narang Shamsher Singh; Objective:To assess the effect of sericin against pentylenetetrazole(PTZ)kindling epilepsy and its associated comorbidities.Methods:Epilepsy was induced with PTZ at the dose of 30 mg/kg i.p.on alternative days for 25 ...; 关键词：PENTYLENETETRAZOLE SERICIN GABA-T EPILEPSY ANXIETY Cognitive impairment

Activation of metabotropic glutamate receptor 1 regulates hippocampal CA1 region excitability in rats with status epilepticus by suppressing the HCN1 channel: 《Neural Regeneration Research》2023年第3期594-602,共9页Xiao-Dan Luo Tao Xiang Si-Jun Li Mei-Gang Ma Mei-Ling Chen Yuan Wu; supported by the National Natural Science Foundation of China,No.81760242(to MGM).; Dysregulation of hyperpolarization-activated cyclic nucleotide-gated cation(HCN)channels alters neuronal excitability.However,the role of HCN channels in status epilepticus is not fully understood.In this study,we est...; 关键词：(RS)-3 5-dihydroxyphenylglycine CA1 region EXCITABILITY H89 HCN1 channel LY367385 MGLUR1 PENTYLENETETRAZOLE status epilepticus

Intranasal ginsenoside Rb1 protects pentyl⁃enetetrazole-induced epileptic mice: 《中国药理学与毒理学杂志》2021年第9期673-673,共1页LI Juan LIU Yu-shu WANG Xi LIU Ying MA Qing TANG Min-ke; OBJECTIVE To evaluate whether ginsenoside Rb1 has antiepileptic effects on pen⁃tylenetetrazole(PTZ)-induced epileptic mice via intranasal therapeutic administration.METHODS Rb1 monoclonal antibody was used to observe ...; 关键词：ginsenoside Rb1 antiepileptic effects epileptic mice PENTYLENETETRAZOLE wireless electroencephalogram

Pharmacokinetic, pharmacodynamic, and neurochemical investigations of lamotrigine-pentylenetetrazole kindled mice to ascertain it as a reliable model for clinical drug-resistant epilepsy被引量：4: 《Animal Models and Experimental Medicine》2020年第3期245-255,共11页Sandeep Kumar Rajesh K.Goel; Background:Pentylenetetrazole kindling has long been used for the screening of investigational antiseizure drugs.The presence of lamotrigine,at a very low dose,does not hamper kindling in mice;rather it modifies this ...; 关键词：animal models drug-resistant epilepsy KINDLING LAMOTRIGINE refractory epilepsy

Rongchang and Xifeng capsules suppress pentylenetetrazole-induced seizures and change rest/wake behavior in zebrafish larvae: 《Journal of Traditional Chinese Medicine》2019年第6期875-884,共10页Zhang Shuhui Xu Jia Wang Chao Feng Daofu Dai Liangti Kuang Xiangyu Zhu Shuyi Fang Yongchun Chen Dongyan He Xianghui Feng Xizeng; Supported by the Chinese National Natural Science Foundation of China:In situ microscopic Analysis and manipulator for Life Science(No.61327802);the Chinese National Natural Science Foundation of China:Functional Nanoparticle Drug Vector for Zebrafish Development and Biocompatible Assessmen(No.81501589);the Chinese National Natural Science Foundation of China:Development of a cross-scale fast AFM system for life science(No.61127006);the Chinese National Natural Science Foundation of China:Study on the Method of Automatic Nano-manipulation for Cell-Oriented Accurate Displacement(No.61633012);the Tianjin Science Technology Research Funds of China:the function of Rab23 gene in zebrafish development(No.14JCQNJC09600);the National Basic Research Program of China:The Basic and Frontier of the New Topological Structure of the Molecular-based Functional Carbon Materials(No.2015CB856500); OBJECTIVE:To evaluate the effects of Rongchang capsule and Xifeng capsule on pentylenetetrazoleinduced epilepsy in zebrafish larvae and to explore the possible mechanisms behind their actions.METHODS:We utilized a tra...; 关键词：Zebrafish Larva ANTICONVULSANTS Rongchang capsule Xifeng capsule Rest/wake behavior

Gastrodin Attenuates Pentylenetetrazole-Induced Seizures by Modulating the Mitogen-Activated Protein Kinase-Associated Inflammatory Responses in Mice被引量：37: 《Neuroscience Bulletin》2017年第3期264-272,共9页Liming Chen Xinan Liu Hua Wang Min Qu; Gastrodin, the major component isolated from the rhizome of the Chinese traditional medicinal herb Gastrodia elata（‘‘Tianma＇＇）, has a long history in the treatment of epilepsy and other neurological disorders.Ho...; 关键词：Gastrodin Epilepsy IL-1b TNF-a IL-10 MAPK CREB NF-j B

Evaluation of the anticonvulsant activity of the essential oil of Myrothamnus moschatus in convulsion induced by pentylenetetrazole and picrotoxin: 《Asian Pacific Journal of Tropical Biomedicine》2016年第6期501-505,共5页Emmanuel Randrianarivo Filippo Maggi Marcello Nicoletti Philippe Rasoanaivo; Supported by the University Research Fund 2014/2015 of the University of Camerino under the grant number FPI000044; Objective: To evaluate the anticonvulsant effect of the essential oil of Myrothamnus moschatus(M. moschatus) in convulsion induced by pentylenetetrazole and picrotoxin in rodent models.Methods: The essential oil of th...; 关键词：Myrothamnus moschatus ESSENTIAL OIL CONVULSIONS PENTYLENETETRAZOLE PICROTOXIN

Chaihushugan decoction exerts antiepileptic effects by increasing hippocampal glutamate metabolism in pentylenetetrazole-kindled rats被引量：9: 《Journal of Traditional Chinese Medicine》2015年第6期659-665,共7页Yu Yunhong Xie Wei Wang Changjun; Supported by Guangdong Natural Science Foundation(The effects of "Treatment from Gan"on Regulation of A-type Potassium Channels by KChIP/Kv4 in the pathomechanism of Refractory Epilepsy,No.2014A030310052);National Natural Science Foundation of China(Study on Regulation of A-type Potassium Channels by KChIP/Kv4 in the Pathomechanism of Refractory Epilepsy and the Effects of "Treatment from Gan",No.81503564); OBJECTIVE: To investigate the antiepileptic effects of Chaihushugan decoction(CHSGD) in rats with pentylenetetrazole(PTZ)-induced seizures and to discuss the impact of CHSGD on glutamate metabolism, a hypothesized und...; 关键词：Epilepsy PENTYLENETETRAZOLE Chaihushugan decoction 2-(N-(7-nitrobenz-2-oxa-1 3-diazol-4-yl)amino)-2-deoxyglucose Glutamic acid Glutamate plasma membrane transport proteins Glutamate-ammonia ligase

Low-frequency stimulation of the external globus palladium produces anti-epileptogenic and anti- ictogenic actions in rats被引量：2: 《Acta Pharmacologica Sinica》2015年第8期957-965,共9页Hui CHENG Yi-fang KUANG Yang LIU Yi WANG Zheng-hao XU Feng GAO Shi-hong ZHANG Mei-ping DING Zhong CHEN; Aim： To investigate the anti-epileptic effects of deep brain stimulation targeting the external globus palladium （GPe） in rats. Methods： For inducing amygdala kindling and deep brain stimulation, bipolar stainless...; 关键词：epilepsy deep brain stimulation external globus palladium seizures amygdala kindling maximal electroshock model pentylenetetrazole model electroencephalogram

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