Sericin alleviates pentylenetetrazole kindling epilepsy and associated comorbidities via modulation of GABA-T enzyme and mitochondrial activity  

作　　者：Sania Grover Raj Kumar Narang Shamsher Singh 

机构地区：[1]I.K.Gujral Punjab Technical University,Jalandhar,Punjab,India [2]Department of Pharmaceutics,ISF College of Pharmacy(An Autonomous College),Moga-142001,Punjab,India [3]Neuroscience Division,Department of Pharmacology,ISF College of Pharmacy(An Autonomous College),Moga-142001,Punjab,India

出　　处：《Asian Pacific Journal of Tropical Biomedicine》2023年第10期431-442,共12页亚太热带生物医学杂志（英文版）

摘　　要：Objective:To assess the effect of sericin against pentylenetetrazole(PTZ)kindling epilepsy and its associated comorbidities.Methods:Epilepsy was induced with PTZ at the dose of 30 mg/kg i.p.on alternative days for 25 days in rats.Sericin was administered orally at the doses of 250,500,and 1000 mg/kg for 35 days.The behavioral activities were performed using an elevated plus maze,forced swim test,and Morris water maze test.A PTZ challenge test was conducted on day 32.On day 35,rats were sacrificed to perform oxidative stress,mitochondrial dysfunction,neuroinflammation,neurotransmitters,GABA-T activity,and histopathological analyses.Results:Sericin at 500 and 1000 mg/kg significantly reduced behavioral changes and neuroinflammatory cytokines,as well as improved oxidative stress,mitochondrial enzyme complex activity,neurotransmitter level,and GABA-T enzymatic activity(P<0.05).Moreover,sericin improved the neuronal survival altered by PTZ kindling in rat hippocampus.Conclusions:Sericin mitigates epilepsy-associated secondary complications possibly by the modulation of mitochondrial enzyme complexes and GABA-T enzymatic activity.

关 键 词：PENTYLENETETRAZOLE SERICIN GABA-T EPILEPSY ANXIETY Cognitive impairment 

分 类 号：R285[医药卫生—中药学]