LAMOTRIGINE

作品数：27被引量：43H指数：4
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相关领域：医药卫生更多>>
相关作者：承欧梅张永芳邓伟李丹耿宝琴更多>>
相关机构：中国人民解放军总医院重庆医科大学附属第一医院上海第二医科大学附属仁济医院浙江医科大学更多>>
相关期刊：《Acta Pharmacologica Sinica》《中国临床药学杂志》《转化医学电子杂志》《Open Journal of Medical Psychology》更多>>
相关基金：国家自然科学基金更多>>
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Lamotrigine-induced hemophagocytic lymphohistiocytosis associated with takotsubo cardiomyopathy, renal failure, encephalitis, and hemorrhagic shock
《World Journal of Emergency Medicine》2025年第1期88-90,共3页Ariella Gartenberg Juan Esteban Munoz Eusse Alexander Petrie Tsui Yuen 
Hemophagocytic lymphohistiocytosis (HLH) is an aggressive and often fatal overactivation of the immune system. It is characterized by inappropriate and dysregulated activation of natural killer (NK) cells, CD8^(+)cyto...
关键词：HISTIOCYTOSIS phagocytic HOMEOSTASIS 
Glial Cell-Targeted Treatments for Bipolar Disorder: A Systematic Review of Available Data and Clinical Perspectives
《Open Journal of Medical Psychology》2023年第2期94-115,共22页Julia Wang 
This paper is a systematic review of the treatment of bipolar disorder: a systematic Google Scholar search aimed at treatment guidelines and clinical trials. The search for treatment guidelines returned 375 papers and...
关键词：Astrocytes Bipolar Disorder Brain Cell Size Density GLIA Humans INTERNEURONS Microglia NEUROGLIA Neurons OLIGODENDROCYTES POSTMORTEM Treatment pH Lithium LAMOTRIGINE Valproic Acid 
Lamotrigine protects against cognitive deficits,synapse and nerve cell damage,and hallmark neuropathologies in a mouse model of Alzheimer’s disease被引量：1
《Neural Regeneration Research》2023年第1期189-193,共5页Xin-Xin Fu Rui Duan Si-Yu Wang Qiao-Quan Zhang Bin Wei Ting Huang Peng-Yu Gong Yan E Teng Jiang Ying-Dong Zhang 
supported by the National Natural Science Foundation of China, No. 81771140 (to YDZ);the Natural Science Foundation of Jiangsu Province of China, No. BK20201117 (to YDZ);Jiangsu “Six One Project” for Distinguished Medical Scholars of China, No. LGY2020013 (to TJ)
Lamotrigine(LTG)is a widely used drug for the treatment of epilepsy.Emerging clinical evidence suggests that LTG may improve cognitive function in patients with Alzheimer’s disease.However,the underlying molecular me...
关键词：Alzheimer’s disease Alzheimer’s disease-related neuropathologies amyloid-βpathology APP/PS1 mice cognitive deficits damage of synapses and nerve cells high-throughput RNA sequencing LAMOTRIGINE neuroinflammation tau protein hyperphosphorylation 
Pharmacokinetic, pharmacodynamic, and neurochemical investigations of lamotrigine-pentylenetetrazole kindled mice to ascertain it as a reliable model for clinical drug-resistant epilepsy被引量：4
《Animal Models and Experimental Medicine》2020年第3期245-255,共11页Sandeep Kumar Rajesh K.Goel 
Background:Pentylenetetrazole kindling has long been used for the screening of investigational antiseizure drugs.The presence of lamotrigine,at a very low dose,does not hamper kindling in mice;rather it modifies this ...
关键词：animal models drug-resistant epilepsy KINDLING LAMOTRIGINE refractory epilepsy 
Low-frequency Stimulation at the Subiculum is Anti-convulsant and Anti-drug-resistant in a Mouse Model of Lamotrigine-resistant Temporal Lobe Epilepsy被引量：7
《Neuroscience Bulletin》2020年第6期654-658,共5页Yeping Ruan Cenglin Xu Jile Lan Jiazhen Nao Shuo Zhang Fei Fan Yi Wang Zhong Chen 
supported by grants from the National Natural Science Foundation of China (81703480 and 81603084);the Fundamental Research Funds for Central Universities,China (2019FZA7016 and 2019QNA5001).
Dear Editor,Epilepsy is a common neurological disease.About 30%of epileptic patients develop resistance to antiepileptic drugs(AEDs),and are considered to have refractory or drugresistant epilepsy[1].Based on the time...
关键词：EPILEPSY drug drugs 
Solubility and thermodynamics of lamotrigine in ternary mixtures of ionic liquids([OMIm][Br]+[HMIm][Br]+water)at different temperatures被引量：2
《Chinese Journal of Chemical Engineering》2020年第1期198-207,共10页Mohammad Barzegar-Jalali Abolghasem Jouyban Fleming Martinez Hemayat Shekaari Seyyedeh Narjes Mirheydari 
a postdoctorate grant(693118)of Tabriz University of Medical Sciences,Iran for supporting this work.
Experimental mole fraction solubility of lamotrigine(LTG)in ternary aqueous mixtures of two ionic liquids(ILs),1-hexyl and 1-octyl-3-methylimidazolium bromide,[HMIm][Br]and[OMIm][Br]were reported at several temperatur...
关键词：SOLUBILITY LAMOTRIGINE [OMIm][Br] [HMIm][Br] UNIQUAC Thermodynamic functions 
Development of a simple and rapid method to measure the free fraction of lamotrigine in plasma using HPLC:applications for therapeutic drug monitoring被引量：1
《Journal of Chinese Pharmaceutical Sciences》2018年第12期832-839,共8页Huanxin Wang Yaxin Sun Shansen Xu Tong Lu Yanan Chen Limei Zhao 
Liaoning Province Natural Science Foundation of China(Grant No.2013021079)
Lamotrigine (LTG) is a widely used antiepileptic drug (AED) for the treatment of new-onset, as well as refractory epilepsy. Due to the narrow treatment window and large individual variability in the pharmacokinetics a...
关键词：LAMOTRIGINE Unbound concentration ULTRAFILTRATION HPLC Therapeutic drug monitoring 
Effects of lamotrigine + sodium valproate therapy on the nerve cell nutrition and apoptosis status as well as inflammatory response in patients with intractable epilepsy
《Journal of Hainan Medical University》2018年第1期149-152,共4页Wen Tang Mei-Mei Yang Ya-Ning Tang 
Objective: To investigate the effects of lamotrigine + sodium valproate therapy on the nerve cell nutrition and apoptosis as well as inflammatory response in patients with intractable epilepsy. Methods: A total of 70 ...
关键词：INTRACTABLE EPILEPSY LAMOTRIGINE Sodium valproate NEUROTROPHY APOPTOSIS Inflammatory response 
Patch testing and cross sensitivity study of adverse cutaneous drug reactions due to anticonvulsants: A preliminary report被引量：1
《World Journal of Methodology》2017年第1期25-32,共8页TN Shiny Vikram K Mahajan Karaninder S Mehta Pushpinder S Chauhan Ritu Rawat Rajni Sharma 
AIM To evaluate the utility of patch test and cross-sensitivity patterns in patients with adverse cutaneous drug reactions(ACDR) from common anticonvulsants. METHODS Twenty-four(M:F = 13:11) patients aged 18-75 years ...
关键词：Anticonvulsant hypersensitivity syndrome Carbamazepine Sodium valproate Drug rash with eosinophilia with or without systemic involvement Drug patch test LAMOTRIGINE PHENOBARBITONE PHENYTOIN Stevens-Johnsons syndrome Toxic epidermal necrolysis 
Lamotrigine versus carbamazepine in treating newly diagnosed epilepsy：A meta-analysis
《转化医学电子杂志》2014年第6期29-35,共7页LIU Ya PENG Ya-Wen ZHOU Ke-Cheng QU Cheng-Hao HU Wei 
关键词：转化医学 临床研究 患者 治疗方法 
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