Lamotrigine-induced hemophagocytic lymphohistiocytosis associated with takotsubo cardiomyopathy, renal failure, encephalitis, and hemorrhagic shock  

作　　者：Ariella Gartenberg Juan Esteban Munoz Eusse Alexander Petrie Tsui Yuen 

机构地区：[1]Department of Emergency Medicine,Jacobi Medical Center and Montefi ore Medical Center,Bronx 10461,USA [2]Department of Emergency Medicine,Jacobi Medical Center and North Central Bronx Hospital,Bronx 10461,USA

出　　处：《World Journal of Emergency Medicine》2025年第1期88-90,共3页世界急诊医学杂志(英文)

摘　　要：Hemophagocytic lymphohistiocytosis (HLH) is an aggressive and often fatal overactivation of the immune system. It is characterized by inappropriate and dysregulated activation of natural killer (NK) cells, CD8^(+)cytotoxic T cells, and macrophages. Ineffective interactions between NK cells, CD8^(+)T cells, and their pathogenic targets lead to massive cytokine accumulation and widespread macrophage activation. Resultant hemophagocytosis and excessive organdamaging infl ammation subsequently occur.HLH may be triggered by genetic or sporadic disorders,as well as specific events that alter immune homeostasis.These events include inflammatory or infectious disease processes and malignancy.

关 键 词：HISTIOCYTOSIS phagocytic HOMEOSTASIS 

分 类 号：R593.2[医药卫生—内科学]