Low-frequency Stimulation at the Subiculum is Anti-convulsant and Anti-drug-resistant in a Mouse Model of Lamotrigine-resistant Temporal Lobe Epilepsy  

作　　者：Yeping Ruan Cenglin Xu Jile Lan Jiazhen Nao Shuo Zhang Fei Fan Yi Wang Zhong Chen 

机构地区：[1]College of Pharmaceutical Science,Zhejiang Chinese Medical University,Hangzhou 310000,China [2]Key Laboratory of Medical Neurobiology of National Health Commission and Chinese Academy of Medical Sciences,Institute of Pharmacology and Toxicology,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou 310000,China

出　　处：《Neuroscience Bulletin》2020年第6期654-658,共5页神经科学通报（英文版）

基　　金：supported by grants from the National Natural Science Foundation of China (81703480 and 81603084);the Fundamental Research Funds for Central Universities,China (2019FZA7016 and 2019QNA5001).

摘　　要：Dear Editor,Epilepsy is a common neurological disease.About 30%of epileptic patients develop resistance to antiepileptic drugs(AEDs),and are considered to have refractory or drugresistant epilepsy[1].Based on the time course over which drug-resistance develops,refractory epilepsy can be further divided into an early-onset type(drug-resistance more likely innate and correlated with gene mutations)and a delayed-onset type(drug-resistance emerges after a period of medication)[2].

关 键 词：EPILEPSY drug drugs 

分 类 号：R-332[医药卫生] R742.1