supported by an under-40 grant from the Italian Association for Alzheimer’s Research [AIRALZH AGYR2021];the Strategic University Projects–Young Researcher Independence grant [YRG2021] from the Università Campus Bio-Medico di Roma (Rome, Italy)(to LLB);Italian Ministry of Health [Research Grant:GR-2019-12370446];the American Alzheimer’s Association [AARG-22-922961](to PK)。
Despite decades of dedicated resea rch,Alzheimer's disease (AD) is an age-related and progressive neurodegenerative disorder for which the mechanisms of onset are sti unc ear.AD is cha racterized by featured histologi...
supported by the German Research Foundation DFG grant GA 654/13-2 to OG。
De novo mutations in genes encoding K^(+)channels are implicated in many severe neurodevelopmental disorders.Specifically,mutations in KCNA2,encoding the Shaker-type voltage-gated K^(+)channel Kv1.2,and KCNJ2,encoding...
Striatal interneurons play a key role in modulating striatal-dependent behaviors,including motor activity and reward and emotional processing.Interneurons not only provide modulation to the basal ganglia circuitry und...
FC was supported by the Italian Ministry of Health(Research Grant:GR-2019–12370446);MDA was supported by the American Alzheimer’s Association(AARG-21–851219);the Italian Ministry of Health(Research Grant:RF-2018–12365527);Regione Lazio(PO FESR LAZIO 2014/2020,T0002E0001);the Italian Ministry of Universities and Research(Prot.2020Z73J5A);Fondazione Roma(Rome,Italy);PK was supported by an under-40 grant from the Italian Association for Alzheimer’s Research(AIRALTZH-AGYR2020);the Italian Ministry of Health(Research Grant:GR-2019–12370446);the American Alzheimer’s Association(AARG-22–922961).
The last decades have witnessed huge efforts devoted to deciphering the pathological mechanisms underlying Alzheimer’s Disease(AD)and to testing new drugs,with the recent FDA approval of two anti-amyloid monoclonal a...
supported by STI2030-Major Projects,No.2022ZD0207600 (to LZ);the National Natural Science Foundation of China,Nos.821 71446 (to JY),U22A20301 (to KFS),32070955 (to LZ);Guangdong Basic and Applied Basic Research Foundation,No.202381515040015 (to LZ);Science and Technology Program of Guangzhou of China,No.202007030012 (to KFS and LZ)
Epilepsy frequently leads to cognitive dysfunction and approaches to treatment remain limited.Although regular exercise effectively improves learning and memory functions across multiple neurological diseases,its appl...
supported by the Notional Natural Science Foundation of China,Nos.81371213 and 8107098 7;the Natural Science Foundation of Shanghai,No.21ZR1468400 (all to QLY)。
Extracellular amyloid beta(Aβ) plaques are main pathological feature of Alzheimer’s disease.However,the specific type of neuro ns that produce Aβ peptides in the initial stage of Alzheimer’s disease are unknown.In...
supported by the National Natural Science Foundation of China(31970951);the Six Talent Peaks Project of Jiangsu Province(YY-005);the Shanghai Rising-Star Program(21QA1407900);“Zhong Ying Young Scholar”project of Cyrus Tang Foundation.
Anxiety disorders are currently a major psychiatric and social problem,the mechanisms of which have been only partially elucidated.The hippocampus serves as a major target of stress mediators and is closely related to...
supported by grants from the National Key R&D Program of China(No.2020YFA0803900);the National Natural Science Foundation of China(82071443,81973298,82173796,82022071,82201607);the Natural Science Foundation of Zhejiang Province(LD22H310003,Q23H090002).
Seizures due to cortical dysplasia are notorious for their poor prognosis even with medications and surgery,likely due to the widespread seizure network.Previous studies have primarily focused on the disruption of dys...
This paper is a systematic review of the treatment of bipolar disorder: a systematic Google Scholar search aimed at treatment guidelines and clinical trials. The search for treatment guidelines returned 375 papers and...
supported by the National Natural Science Foundation of China,No. 81870977 (to YW);the Natural Science Foundation of Heilongjiang Province of China,No. JQ2021H004 (to YW);PhD research foundation of Mudanjiang Medicine College,No. 2021-MYBSKY-039 (to WYL);Fundamental Research Funds for Heilongjiang Provincial Universities,No. 2021-KYYWF-0469 (to WYL)。
Chx10-expressing V2 a(Chx10+V2 a) spinal interneurons play a large role in the excitatory drive of motoneurons. Chemogenetic ablation studies have demonstrated the essential nature of Chx10+V2 a interneurons in the re...