INTERNEURONS

作品数:43被引量:55H指数:3
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相关领域:医药卫生生物学更多>>
相关机构:华东师范大学东南大学更多>>
相关期刊:《Cellular & Molecular Immunology》《Science China(Life Sciences)》《Frontiers in Biology》《Chinese Medical Journal》更多>>
相关基金:国家自然科学基金国家重点基础研究发展计划上海市青年科技启明星计划中国博士后科学基金更多>>
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How dopamine tunes parvalbumin interneurons in the hippocampus:new experimental observations in Alzheimer's disease
《Neural Regeneration Research》2025年第5期1405-1406,共2页Livia La Barbera Paraskevi Krashia Annalisa Nobili 
supported by an under-40 grant from the Italian Association for Alzheimer’s Research [AIRALZH AGYR2021];the Strategic University Projects–Young Researcher Independence grant [YRG2021] from the Università Campus Bio-Medico di Roma (Rome, Italy)(to LLB);Italian Ministry of Health [Research Grant:GR-2019-12370446];the American Alzheimer’s Association [AARG-22-922961](to PK)。
Despite decades of dedicated resea rch,Alzheimer's disease (AD) is an age-related and progressive neurodegenerative disorder for which the mechanisms of onset are sti unc ear.AD is cha racterized by featured histologi...
关键词:ALZHEIMER alterations DOPAMINE 
K^(+) channel-mediated retarded maturation of interneurons and its role in neurodevelopmental disorders被引量:1
《Neural Regeneration Research》2024年第7期1403-1404,共2页Kaizhen Li Daria Savitska Olga Garaschuk 
supported by the German Research Foundation DFG grant GA 654/13-2 to OG。
De novo mutations in genes encoding K^(+)channels are implicated in many severe neurodevelopmental disorders.Specifically,mutations in KCNA2,encoding the Shaker-type voltage-gated K^(+)channel Kv1.2,and KCNJ2,encoding...
关键词:DISORDERS ATROPHY 
The dual role of striatal interneurons:circuit modulation and trophic support for the basal ganglia被引量:3
《Neural Regeneration Research》2024年第6期1277-1283,共7页Elliot Wegman Marlena Wosiski-Kuhn Yu Luo 
Striatal interneurons play a key role in modulating striatal-dependent behaviors,including motor activity and reward and emotional processing.Interneurons not only provide modulation to the basal ganglia circuitry und...
关键词:CHOLINERGIC dopamine GABAERGIC INTERNEURON levodopa-induced dyskinesia PARVALBUMIN sonic hedgehog STRIATUM trophic factor 
Transcranial alternating current stimulation(tACS)at gamma frequency:an up-and-coming tool to modify the progression of Alzheimer’s Disease
《Translational Neurodegeneration》2024年第1期640-673,共34页Maria Luisa De Paolis Ilaria Paoletti Claudio Zaccone Fioravante Capone Marcello D’Amelio Paraskevi Krashia 
FC was supported by the Italian Ministry of Health(Research Grant:GR-2019–12370446);MDA was supported by the American Alzheimer’s Association(AARG-21–851219);the Italian Ministry of Health(Research Grant:RF-2018–12365527);Regione Lazio(PO FESR LAZIO 2014/2020,T0002E0001);the Italian Ministry of Universities and Research(Prot.2020Z73J5A);Fondazione Roma(Rome,Italy);PK was supported by an under-40 grant from the Italian Association for Alzheimer’s Research(AIRALTZH-AGYR2020);the Italian Ministry of Health(Research Grant:GR-2019–12370446);the American Alzheimer’s Association(AARG-22–922961).
The last decades have witnessed huge efforts devoted to deciphering the pathological mechanisms underlying Alzheimer’s Disease(AD)and to testing new drugs,with the recent FDA approval of two anti-amyloid monoclonal a...
关键词:Alzheimer’s disease Mild cognitive impairment Non-invasive brain stimulation NEUROMODULATION Brain waves Gamma oscillations Parvalbumin interneurons Network dysfunction Early intervention Theranostic approach 
Treadmill exercise improves hippocampal neural plasticity and relieves cognitive deficits in a mouse model of epilepsy被引量:2
《Neural Regeneration Research》2024年第3期657-662,共6页Hang Yu Mingting Shao Xi Luo Chaoqin Pang Kwok-Fai So Jiandong Yu Li Zhang 
supported by STI2030-Major Projects,No.2022ZD0207600 (to LZ);the National Natural Science Foundation of China,Nos.821 71446 (to JY),U22A20301 (to KFS),32070955 (to LZ);Guangdong Basic and Applied Basic Research Foundation,No.202381515040015 (to LZ);Science and Technology Program of Guangzhou of China,No.202007030012 (to KFS and LZ)
Epilepsy frequently leads to cognitive dysfunction and approaches to treatment remain limited.Although regular exercise effectively improves learning and memory functions across multiple neurological diseases,its appl...
关键词:blood-brain barrier COGNITION HIPPOCAMPUS INTERNEURONS long-term potentiation microglial cell NEUROINFLAMMATION spatial memory temporal epilepsy treadmill exercise 
Inhibiting 5-hydroxytryptamine receptor 3 alleviates pathological changes of a mouse model of Alzheimer's disease被引量:1
《Neural Regeneration Research》2023年第9期2019-2028,共10页Li-Fen Liu Yu-Tong Liu Dan-Dan Wu Jie Cheng Na-Na Li Ya-Ni Zheng Liang Huang Qiong-Lan Yuan 
supported by the Notional Natural Science Foundation of China,Nos.81371213 and 8107098 7;the Natural Science Foundation of Shanghai,No.21ZR1468400 (all to QLY)。
Extracellular amyloid beta(Aβ) plaques are main pathological feature of Alzheimer’s disease.However,the specific type of neuro ns that produce Aβ peptides in the initial stage of Alzheimer’s disease are unknown.In...
关键词:5-hydroxytryptamin receptor 3 Alzheimer’s disease amyloid beta plaques CALCINEURIN cognitive deficits HTR3 interneurons iCa2+ nuclear factor of activated T-cells transgenic amyloid precursor protein and presenilin-1 mice TROPISETRON 
Hippocampus:Molecular,Cellular,and Circuit Features in Anxiety被引量:3
《Neuroscience Bulletin》2023年第6期1009-1026,共18页Hu-Jiang Shi Shuang Wang Xin-Ping Wang Rui-Xin Zhang Li-Juan Zhu 
supported by the National Natural Science Foundation of China(31970951);the Six Talent Peaks Project of Jiangsu Province(YY-005);the Shanghai Rising-Star Program(21QA1407900);“Zhong Ying Young Scholar”project of Cyrus Tang Foundation.
Anxiety disorders are currently a major psychiatric and social problem,the mechanisms of which have been only partially elucidated.The hippocampus serves as a major target of stress mediators and is closely related to...
关键词:ANXIETY HIPPOCAMPUS Excitatory neurons INTERNEURONS Neural circuit 
Excitatory somatostatin interneurons in the dentate gyrus drive a widespread seizure network in cortical dysplasia被引量:2
《Signal Transduction and Targeted Therapy》2023年第6期3111-3122,共12页Yang Zheng Cenglin Xu Jinyi Sun Wenjie Ming Sijie Dai Yuying Shao Xiaoyun Qiu Menghan Li Chunhong Shen Jinghong Xu Fan Fei Jiajia Fang Xuhong Jiang Guoqing Zheng Weiwei Hu Yi Wang Shuang Wang Meiping Ding Zhong Chen 
supported by grants from the National Key R&D Program of China(No.2020YFA0803900);the National Natural Science Foundation of China(82071443,81973298,82173796,82022071,82201607);the Natural Science Foundation of Zhejiang Province(LD22H310003,Q23H090002).
Seizures due to cortical dysplasia are notorious for their poor prognosis even with medications and surgery,likely due to the widespread seizure network.Previous studies have primarily focused on the disruption of dys...
关键词:SOMATOSTATIN DYSPLASIA SEIZURE 
Glial Cell-Targeted Treatments for Bipolar Disorder: A Systematic Review of Available Data and Clinical Perspectives
《Open Journal of Medical Psychology》2023年第2期94-115,共22页Julia Wang 
This paper is a systematic review of the treatment of bipolar disorder: a systematic Google Scholar search aimed at treatment guidelines and clinical trials. The search for treatment guidelines returned 375 papers and...
关键词:Astrocytes Bipolar Disorder Brain Cell Size Density GLIA Humans INTERNEURONS Microglia NEUROGLIA Neurons OLIGODENDROCYTES POSTMORTEM Treatment pH Lithium LAMOTRIGINE Valproic Acid 
Chx10+V2a interneurons in spinal motor regulation and spinal cord injury被引量:3
《Neural Regeneration Research》2023年第5期933-939,共7页Wen-Yuan Li Ling-Xiao Deng Feng-Guo Zhai Xiao-Yu Wang Zhi-Gang Li Ying Wang 
supported by the National Natural Science Foundation of China,No. 81870977 (to YW);the Natural Science Foundation of Heilongjiang Province of China,No. JQ2021H004 (to YW);PhD research foundation of Mudanjiang Medicine College,No. 2021-MYBSKY-039 (to WYL);Fundamental Research Funds for Heilongjiang Provincial Universities,No. 2021-KYYWF-0469 (to WYL)。
Chx10-expressing V2 a(Chx10+V2 a) spinal interneurons play a large role in the excitatory drive of motoneurons. Chemogenetic ablation studies have demonstrated the essential nature of Chx10+V2 a interneurons in the re...
关键词:AXONS central nervous system central pattern generator Chx10 differentiation INTERNEURONS locomotion motor neurons PROPRIOSPINAL spinal cord injuries therapy transcription factor transplantation V2a neuron 
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