Transcranial alternating current stimulation(tACS)at gamma frequency:an up-and-coming tool to modify the progression of Alzheimer’s Disease  

作　　者：Maria Luisa De Paolis Ilaria Paoletti Claudio Zaccone Fioravante Capone Marcello D’Amelio Paraskevi Krashia 

机构地区：[1]Department of Medicine and Surgery,UniversitàCampus Bio-Medico Di Roma,Via Alvaro del Portillo,21-00128 Rome,Italy [2]Fondazione Policlinico Universitario Campus Bio-Medico,Via Alvaro del Portillo,200-00128 Rome,Italy [3]Department of Experimental Neurosciences,IRCCS Santa Lucia Foundation,Via del Fosso Di Fiorano,64-00143 Rome,Italy [4]Department of Sciences and Technologies for Sustainable Development and One Health,UniversitàCampus Bio-Medico Di Roma,Via Alvaro del Portillo,21-00128 Rome,Italy

出　　处：《Translational Neurodegeneration》2024年第1期640-673,共34页转化神经变性病(英文)

基　　金：FC was supported by the Italian Ministry of Health(Research Grant:GR-2019–12370446);MDA was supported by the American Alzheimer’s Association(AARG-21–851219);the Italian Ministry of Health(Research Grant:RF-2018–12365527);Regione Lazio(PO FESR LAZIO 2014/2020,T0002E0001);the Italian Ministry of Universities and Research(Prot.2020Z73J5A);Fondazione Roma(Rome,Italy);PK was supported by an under-40 grant from the Italian Association for Alzheimer’s Research(AIRALTZH-AGYR2020);the Italian Ministry of Health(Research Grant:GR-2019–12370446);the American Alzheimer’s Association(AARG-22–922961).

摘　　要：The last decades have witnessed huge efforts devoted to deciphering the pathological mechanisms underlying Alzheimer’s Disease(AD)and to testing new drugs,with the recent FDA approval of two anti-amyloid monoclonal antibodies for AD treatment.Beyond these drug-based experimentations,a number of pre-clinical and clinical trials are exploring the benefits of alternative treatments,such as non-invasive stimulation techniques on AD neuropathology and symptoms.Among the different non-invasive brain stimulation approaches,transcranial alternating current stimulation(tACS)is gaining particular attention due to its ability to externally control gamma oscillations.Here,we outline the current knowledge concerning the clinical efficacy,safety,ease-of-use and cost-effectiveness of tACS on early and advanced AD,applied specifically at 40 Hz frequency,and also summarise pre-clinical results on validated models of AD and ongoing patient-centred trials.

关 键 词：Alzheimer’s disease Mild cognitive impairment Non-invasive brain stimulation NEUROMODULATION Brain waves Gamma oscillations Parvalbumin interneurons Network dysfunction Early intervention Theranostic approach 

分 类 号：R74[医药卫生—神经病学与精神病学]