Treadmill exercise improves hippocampal neural plasticity and relieves cognitive deficits in a mouse model of epilepsy  

作　　者：Hang Yu Mingting Shao Xi Luo Chaoqin Pang Kwok-Fai So Jiandong Yu Li Zhang 

机构地区：[1]Key Laboratory of CNS Regeneration(Ministry of Education),Guangdong-Hong Kong-Macao Institute of CNS Regeneration,Jinan University,Guangzhou,Guangdong Province,China [2]State Key Laboratory of Brain and Cognitive Science,Li Ka Shing Faculty of Medicine,The University of Hong Kong,Hong Kong Special Administrative Region,China [3]Neuroscience and Neurorehabilitation Institute,University of Health and Rehabilitation Sciences,Qingdao,Shandong Province,China [4]Department of Neurosurgery,The First Affiliated Hospital of Bengbu Medical College,Bengbu,Shandong Province,China [5]School of Psychology,Shanghai University of Sport,Shanghai,China

出　　处：《Neural Regeneration Research》2024年第3期657-662,共6页中国神经再生研究（英文版）

基　　金：supported by STI2030-Major Projects,No.2022ZD0207600 (to LZ);the National Natural Science Foundation of China,Nos.821 71446 (to JY),U22A20301 (to KFS),32070955 (to LZ);Guangdong Basic and Applied Basic Research Foundation,No.202381515040015 (to LZ);Science and Technology Program of Guangzhou of China,No.202007030012 (to KFS and LZ)

摘　　要：Epilepsy frequently leads to cognitive dysfunction and approaches to treatment remain limited.Although regular exercise effectively improves learning and memory functions across multiple neurological diseases,its application in patients with epilepsy remains controversial.Here,we adopted a 14-day treadmill-exercise paradigm in a pilocarpine injection-induced mouse model of epilepsy.Cognitive assays confirmed the improvement of object and spatial memory after endurance training,and electrophysiological studies revealed the maintenance of hippocampal plasticity as a result of physical exercise.Investigations of the mechanisms underlying this effect revealed that exercise protected parvalbumin interneurons,probably via the suppression of neuroinflammation and improved integrity of blood-brain barrier.In summary,this work identified a previously unknown mechanism through which exercise improves cognitive rehabilitation in epilepsy.

关 键 词：blood-brain barrier COGNITION HIPPOCAMPUS INTERNEURONS long-term potentiation microglial cell NEUROINFLAMMATION spatial memory temporal epilepsy treadmill exercise 

分 类 号：R742.1[医药卫生—神经病学与精神病学] R-332[医药卫生—临床医学]