The dual role of striatal interneurons:circuit modulation and trophic support for the basal ganglia  

作　　者：Elliot Wegman Marlena Wosiski-Kuhn Yu Luo 

机构地区：[1]Department of Molecular and Cellular Biosciences,University of Cincinnati,Cincinnati,OH,USA [2]Department of Emergency Medicine at the School of Medicine,University of Cincinnati,Cincinnati,OH,USA [3]Neuroscience Graduate Program,University of Cincinnati,Cincinnati,OH,USA

出　　处：《Neural Regeneration Research》2024年第6期1277-1283,共7页中国神经再生研究（英文版）

摘　　要：Striatal interneurons play a key role in modulating striatal-dependent behaviors,including motor activity and reward and emotional processing.Interneurons not only provide modulation to the basal ganglia circuitry under homeostasis but are also involved in changes to plasticity and adaptation during disease conditions such as Parkinson's or Huntington's disease.This review aims to summarize recent findings regarding the role of striatal cholinergic and GABAergic interneurons in providing circuit modulation to the basal ganglia in both homeostatic and disease conditions.In addition to direct circuit modulation,striatal interneurons have also been shown to provide trophic support to maintain neuron populations in adulthood.We discuss this interesting and novel role of striatal interneurons,with a focus on the maintenance of adult dopaminergic neurons from interneuronderived sonic-hedgehog.

关 键 词：CHOLINERGIC dopamine GABAERGIC INTERNEURON levodopa-induced dyskinesia PARVALBUMIN sonic hedgehog STRIATUM trophic factor 

分 类 号：R338[医药卫生—人体生理学]