GLIA

作品数：132被引量：281H指数：9
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Single-cell RNA sequencing reveals the heterogeneity and interactions of immune cells and Müller glia during zebrafish retina regeneration
《Neural Regeneration Research》2025年第12期3635-3648,共14页Hui Xu Lining Cao Yuxi Chen Cuiping Zhou Jie Xu Zhuolin Zhang Xiangyu Li Lihua Liu Jianfeng Lu 
supported by the National Natural Science Foundation of China,Nos.81970820(to HX),31771644(to JL),31930068(to JL),82371176(to JL),81801331(to LC);National Key Research and Development Project of China.Nos.2017YFA0104100(to JL),2017YFA0701304(to HX);Shanghai Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center)Talent Introduction Plan,No.KYPT202204(to LC);the Fundamental Research Funds for the Central Universities,No.22120230292(to JL)。
Inflammation plays a crucial role in the regeneration of fish and avian retinas.However,how inflammation regulates Müller glia(MG)reprogramming remains unclear.Here,we used single-cell RNA sequencing to investigate t...
关键词：immune cells inflammation Jak1-Stat3 signaling microglia Müller glia REGENERATION reprogramming RETINA single-cell RNAseq ZEBRAFISH 
Olfactory receptors in neural regeneration in the central nervous system
《Neural Regeneration Research》2025年第9期2480-2494,共15页Rafael Franco Claudia Garrigós Toni Capó Joan Serrano-Marín Rafael Rivas-Santisteban Jaume Lillo 
Olfactory receptors are crucial for detecting odors and play a vital role in our sense of smell,influencing behaviors from food choices to emotional memories.These receptors also contribute to our perception of flavor...
关键词：adenosine receptors adrenergic receptors ectopic expression G proteincoupled receptors GLIA NEURONS 
Differential response of injured and healthy retinas to syngeneic and allogeneic transplantation of a clonal cell line of immortalized olfactory ensheathing glia:a double-edged sword
《Neural Regeneration Research》2025年第8期2395-2407,共13页María Norte-Muñoz María Portela-Lomba Paloma Sobrado-Calvo Diana Simón Johnny Di Pierdomenico Alejandro Gallego-Ortega Mar Pérez JoséMCabrera-Maqueda Javier Sierra Manuel Vidal-Sanz María Teresa Moreno-Flores Marta Agudo-Barriuso 
supported by the Spanish Ministry of Economy and Competitiveness,No.PID2019-106498GB-I00(to MVS);the Instituto de Salud CarlosⅢ,Fondo Europeo de Desarrollo Regional“Una manera de hacer Europa”,No.PI19/00071(to MAB);Ministerio de Ciencia e Innovación Project,No.SAF2017-82736-C2-1-R(to MTMF)in Universidad Autónoma de Madrid;Fundación Universidad Francisco de Vitoria(to JS)。
Olfactory ensheathing glia promote axonal regeneration in the mammalian central nervous system,including retinal ganglion cell axonal growth through the injured optic nerve.Still,it is unknown whether olfactory enshea...
关键词：cell therapy immune recognition major histocompatibility complex class II(MHCII) neuroprotection olfactory ensheathing glia retinal ganglion cells 
Investigating Müller glia reprogramming in mice: a retrospective of the last decade, and a look to the future
《Neural Regeneration Research》2025年第4期946-959,共14页Zhiyuan Yin Jiahui Kang Xuan Cheng Hui Gao Shujia Huo Haiwei Xu 
supported by the National Natural Science Foundation of China,No.31930068;National Key Research and Development Program of China,Nos.2018YFA0107302 and 2021YFA1101203(all to HX).
Müller glia,as prominent glial cells within the retina,plays a significant role in maintaining retinal homeostasis in both healthy and diseased states.In lower vertebrates like zebrafish,these cells assume responsibi...
关键词：cell fusion chemical small-molecules EPIGENETIC extracellular matrix immune metabolic MICE Müller glia neurodegenerative diseases REPROGRAMMING retina regeneration 
Postnatal development of rat retina:a continuous observation and comparison between the organotypic retinal explant model and in vivo development
《Neural Regeneration Research》2025年第3期900-912,共13页Baoqi Hu Rui Wang Hanyue Zhang Xiou Wang Sijia Zhou Bo Ma Yan Luan Xin Wang Xinlin Chen Zhichao Zhang Qianyan Kang 
supported by the National Natural Science Foundation of China,Nos.81901156(to ZZ),82271200(to ZZ),82171308(to XC);the Fundamental Research Funds for the Central Universities,No.xzy012022035(to ZZ);the Natural Science Foundation of Shaanxi Province,Nos.2021JM-261(to QK),2023-YBSF-303(to ZZ);Traditional Chinese Medicine Project of Shaanxi Province,No.2019-ZZ-JC047(to QK)。
The organotypic retinal explant culture has been established for more than a decade and offers a range of unique advantages compared with in vivo experiments and cell cultures.However,the lack of systematic and contin...
关键词：bipolar cells differentiation in vivo microglia Müller glia organotypic retinal explant culture postnatal retina development proliferation retinal progenitor cells 
Huanglian-Renshen-Decoction Maintains Isletβ-Cell Identity in T2DM Mice through Regulating GLP-1 and GLP-1R in Both Islet and Intestine
《Chinese Journal of Integrative Medicine》2025年第1期39-48,共10页WU Wen-bin GAO Fan TANG Yue-heng WANG Hong-zhan DONG Hui LU Fu-er YUAN Fen 
Supported by the National Natural Science Foundation of China(No.82004358)。
Objective: To elucidate the effect of Huanglian-Renshen-Decoction(HRD) on ameliorating type 2 diabetes mellitus by maintaining islet β-cell identity through regulating paracrine and endocrine glucagon-like peptide-1(...
关键词：type 2 diabetes mellitus Huanglian-Renshen-Decoction isletβcell glucagon-like peptide-1 glucagon-like peptide-1 receptor Chinese medicine 
Exploiting fly models to investigate rare human neurological disorders
《Neural Regeneration Research》2025年第1期21-28,共8页Tomomi Tanaka Hyung-Lok Chung 
supported by Warren Alpert Foundation and Houston Methodist Academic Institute Laboratory Operating Fund(to HLC).
Rare neurological diseases,while individually are rare,collectively impact millions globally,leading to diverse and often severe neurological symptoms.Often attributed to genetic mutations that disrupt protein functio...
关键词：ACOX1 Drosophila melanogaster GLIA lipid metabolism model organisms NEUROINFLAMMATION neurologic disorders NEURON rare disease VLCFA 
Hedgehog信号通路与缺血性脑卒中相关性的研究进展
《海南医学院学报》2024年第23期1827-1832,共6页王亚敏 吕转 高静 冯晓东 
国家自然科学基金资助项目(82174473,U2004131);河南省科技研发计划联合基金(222301420064)。
缺血性脑卒中是一种常见的、具有严重危害性的脑血管疾病。Hedgehog信号通路是一个经典的控制胚胎发育的信号途径,在胚胎发育和胚胎形成后细胞生长、增殖过程中起着关键作用。该通路通过调控神经炎症、血脑屏障、血管生成、神经元和突...
关键词：缺血性脑卒中 HEDGEHOG PTCH SMO GLIA 
Recent progress of principal techniques used in the study of Müller glia reprogramming in mice
《Cell Regeneration》2024年第1期39-54,共16页Zhiyuan Yin Jiahui Kang Haoan Xu Shujia Huo Haiwei Xu 
National Key Research and Development Program of China(Grant No.2021YFA1101203).
In zebrafish,Müller glia(MG)cells retain the ability to proliferate and de-differentiate into retinal progenitor-like cells,subsequently differentiating into retinal neurons that can replace those damaged or lost due...
关键词：Müller glia REPROGRAMMING RETINA MICE Multi-omics Technique 
Impaired pericyte-Müller glia interaction via PDGFRβ suppression aggravates photoreceptor loss in a rodent model of light-induced retinal injury
《International Journal of Ophthalmology(English edition)》2024年第10期1800-1808,共9页Wei Xu Li-Jin Cui Xiao-Ying Yang Xiao-Yuan Cui Jian Guo Guo-Xing Xu 
Supported by National Natural Science Foundation of China(No.81900862)。
AIM:To investigate the involvement of pericyte-Müller glia interaction in retinal damage repair and assess the influence of suppressing the platelet-derived growth factor receptorβ(PDGFRβ)signaling pathway in retin...
关键词：PERICYTE Müller glia light-induced retinal injury platelet-derived growth factor receptorβ signal pathway 
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