GLIA

作品数：136被引量：282H指数：9
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相关机构：武汉大学北京市神经外科科研究所哈尔滨医科大学北京军区总医院更多>>
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Neuronal guidance signaling in neurodegenerative diseases:Key regulators that function at neuron-glia and neuroimmune interfaces
《Neural Regeneration Research》2026年第2期612-635,共24页Junichi Yuasa-Kawada Mariko Kinoshita-Kawada Masaki Hiramoto Satoru Yamagishi Takayasu Mishima Shin’ichiro Yasunaga Yoshio Tsuboi Nobutaka Hattori Jane Y.Wu 
supported by JSPS(KAKENHI:21K06205,23K06937,24K23419);AMED(to JYK,SaY,TM,SiY,YT,and NH);JYW had long been supported by the NIH.
The nervous system processes a vast amount of information,performing computations that underlie perception,cognition,and behavior.During development,neuronal guidance genes,which encode extracellular cues,their recept...
关键词：amyloid-β axon guidance NEURODEGENERATION neuroimmune interactions neuroinflammation neuron-glia interactions neurovascular interactions SEMAPHORIN synaptic remodeling tau TDP-43 TREM2 Α-SYNUCLEIN 
Single-cell RNA sequencing reveals the heterogeneity and interactions of immune cells and Müller glia during zebrafish retina regeneration
《Neural Regeneration Research》2025年第12期3635-3648,共14页Hui Xu Lining Cao Yuxi Chen Cuiping Zhou Jie Xu Zhuolin Zhang Xiangyu Li Lihua Liu Jianfeng Lu 
supported by the National Natural Science Foundation of China,Nos.81970820(to HX),31771644(to JL),31930068(to JL),82371176(to JL),81801331(to LC);National Key Research and Development Project of China.Nos.2017YFA0104100(to JL),2017YFA0701304(to HX);Shanghai Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center)Talent Introduction Plan,No.KYPT202204(to LC);the Fundamental Research Funds for the Central Universities,No.22120230292(to JL)。
Inflammation plays a crucial role in the regeneration of fish and avian retinas.However,how inflammation regulates Müller glia(MG)reprogramming remains unclear.Here,we used single-cell RNA sequencing to investigate t...
关键词：immune cells inflammation Jak1-Stat3 signaling microglia Müller glia REGENERATION reprogramming RETINA single-cell RNAseq ZEBRAFISH 
Olfactory receptors in neural regeneration in the central nervous system
《Neural Regeneration Research》2025年第9期2480-2494,共15页Rafael Franco Claudia Garrigós Toni Capó Joan Serrano-Marín Rafael Rivas-Santisteban Jaume Lillo 
Olfactory receptors are crucial for detecting odors and play a vital role in our sense of smell,influencing behaviors from food choices to emotional memories.These receptors also contribute to our perception of flavor...
关键词：adenosine receptors adrenergic receptors ectopic expression G proteincoupled receptors GLIA NEURONS 
Differential response of injured and healthy retinas to syngeneic and allogeneic transplantation of a clonal cell line of immortalized olfactory ensheathing glia:a double-edged sword
《Neural Regeneration Research》2025年第8期2395-2407,共13页María Norte-Muñoz María Portela-Lomba Paloma Sobrado-Calvo Diana Simón Johnny Di Pierdomenico Alejandro Gallego-Ortega Mar Pérez JoséMCabrera-Maqueda Javier Sierra Manuel Vidal-Sanz María Teresa Moreno-Flores Marta Agudo-Barriuso 
supported by the Spanish Ministry of Economy and Competitiveness,No.PID2019-106498GB-I00(to MVS);the Instituto de Salud CarlosⅢ,Fondo Europeo de Desarrollo Regional“Una manera de hacer Europa”,No.PI19/00071(to MAB);Ministerio de Ciencia e Innovación Project,No.SAF2017-82736-C2-1-R(to MTMF)in Universidad Autónoma de Madrid;Fundación Universidad Francisco de Vitoria(to JS)。
Olfactory ensheathing glia promote axonal regeneration in the mammalian central nervous system,including retinal ganglion cell axonal growth through the injured optic nerve.Still,it is unknown whether olfactory enshea...
关键词：cell therapy immune recognition major histocompatibility complex class II(MHCII) neuroprotection olfactory ensheathing glia retinal ganglion cells 
Investigating Müller glia reprogramming in mice: a retrospective of the last decade, and a look to the future
《Neural Regeneration Research》2025年第4期946-959,共14页Zhiyuan Yin Jiahui Kang Xuan Cheng Hui Gao Shujia Huo Haiwei Xu 
supported by the National Natural Science Foundation of China,No.31930068;National Key Research and Development Program of China,Nos.2018YFA0107302 and 2021YFA1101203(all to HX).
Müller glia,as prominent glial cells within the retina,plays a significant role in maintaining retinal homeostasis in both healthy and diseased states.In lower vertebrates like zebrafish,these cells assume responsibi...
关键词：cell fusion chemical small-molecules EPIGENETIC extracellular matrix immune metabolic MICE Müller glia neurodegenerative diseases REPROGRAMMING retina regeneration 
YAP Signaling in Glia:Pivotal Roles in Neurological Development,Regeneration and Diseases
《Neuroscience Bulletin》2025年第3期501-519,共19页Lin Lin Yinfeng Yuan Zhihui Huang Yongjie Wang 
supported by the Natural Science Foundation of Zhejiang Province(LZ23C090001,LY23H090001);the National Natural Science Foundation of China(82071230).
Yes-associated protein (YAP), the key transcriptional co-factor and downstream effector of the Hippo pathway, has emerged as one of the primary regulators of neural as well as glial cells. It has been detected in vari...
关键词：YAP Hippo pathway NEUROGLIA Nervous system Nervous system diseases 
NG2 Glia:The Guardians Against Prion‑induced Neurotoxicity Through Prostaglandin E2 Blockade
《Neuroscience Bulletin》2025年第3期539-542,共4页Shu Feng Emily Parker Timon Cheng‑Yi Liu Luodan Yang 
supported by the National Natural Science Foundation of China(32300959);a Guangzhou Scientific Research Grant(SL2024A04J00578);the SCNU Young Faculty Development Program(22KJ04).
Neuron glia antigen-2(NG2)glia,also known as oligodendrocyte precursor cells(OPCs),are essential for maintaining the normal function and structure of the central nervous system(CNS)due to their supportive role[1].Unde...
关键词：maintaining normal function structure myelin sheath axons oligodendrocyte precursor cells opcs receiving synaptic input neurons NEUROTOXICITY PRION central nervous system cns due ng glia 
Retinal Focus on Relationships between Diet-Induced, Advanced Glycation End Products and Supplemental Estradiol
《BIOCELL》2025年第3期349-354,共6页Nicholas T.Bello Bonnie L.Firestein Maribel Vazquez 
funded by a Life Sciences Alliance Pilot Seed Grant from the Rutgers-New Brunswick Office of the Vice Provost for Research,Grant Number OVPR-100(MV)。
Neurodegeneration of retinal tissue leads to progressive vision loss in millions of working-age adults each year.Metabolic alterations caused by modern diets that are high in fats and sugars contribute to the developm...
关键词：Muller glia endothelial cells HYPERGLYCEMIA diabetes 
Postnatal development of rat retina:a continuous observation and comparison between the organotypic retinal explant model and in vivo development
《Neural Regeneration Research》2025年第3期900-912,共13页Baoqi Hu Rui Wang Hanyue Zhang Xiou Wang Sijia Zhou Bo Ma Yan Luan Xin Wang Xinlin Chen Zhichao Zhang Qianyan Kang 
supported by the National Natural Science Foundation of China,Nos.81901156(to ZZ),82271200(to ZZ),82171308(to XC);the Fundamental Research Funds for the Central Universities,No.xzy012022035(to ZZ);the Natural Science Foundation of Shaanxi Province,Nos.2021JM-261(to QK),2023-YBSF-303(to ZZ);Traditional Chinese Medicine Project of Shaanxi Province,No.2019-ZZ-JC047(to QK)。
The organotypic retinal explant culture has been established for more than a decade and offers a range of unique advantages compared with in vivo experiments and cell cultures.However,the lack of systematic and contin...
关键词：bipolar cells differentiation in vivo microglia Müller glia organotypic retinal explant culture postnatal retina development proliferation retinal progenitor cells 
Huanglian-Renshen-Decoction Maintains Isletβ-Cell Identity in T2DM Mice through Regulating GLP-1 and GLP-1R in Both Islet and Intestine
《Chinese Journal of Integrative Medicine》2025年第1期39-48,共10页WU Wen-bin GAO Fan TANG Yue-heng WANG Hong-zhan DONG Hui LU Fu-er YUAN Fen 
Supported by the National Natural Science Foundation of China(No.82004358)。
Objective: To elucidate the effect of Huanglian-Renshen-Decoction(HRD) on ameliorating type 2 diabetes mellitus by maintaining islet β-cell identity through regulating paracrine and endocrine glucagon-like peptide-1(...
关键词：type 2 diabetes mellitus Huanglian-Renshen-Decoction isletβcell glucagon-like peptide-1 glucagon-like peptide-1 receptor Chinese medicine 
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