YAP Signaling in Glia:Pivotal Roles in Neurological Development,Regeneration and Diseases  

作　　者：Lin Lin Yinfeng Yuan Zhihui Huang Yongjie Wang 

机构地区：[1]School of Pharmacy,Hangzhou Normal University,Hangzhou 311121,China [2]Key Laboratory of Element Class Anti-Cancer Chinese Medicines,Engineering Laboratory of Development and Application of Traditional Chinese Medicines,Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province,Hangzhou Normal University,Hangzhou 311121,China

出　　处：《Neuroscience Bulletin》2025年第3期501-519,共19页神经科学通报(英文版)

基　　金：supported by the Natural Science Foundation of Zhejiang Province(LZ23C090001,LY23H090001);the National Natural Science Foundation of China(82071230).

摘　　要：Yes-associated protein (YAP), the key transcriptional co-factor and downstream effector of the Hippo pathway, has emerged as one of the primary regulators of neural as well as glial cells. It has been detected in various glial cell types, including Schwann cells and olfactory ensheathing cells in the peripheral nervous system, as well as radial glial cells, ependymal cells, Bergmann glia, retinal Müller cells, astrocytes, oligodendrocytes, and microglia in the central nervous system. With the development of neuroscience, understanding the functions of YAP in the physiological or pathological processes of glia is advancing. In this review, we aim to summarize the roles and underlying mechanisms of YAP in glia and glia-related neurological diseases in an integrated perspective.

关 键 词：YAP Hippo pathway NEUROGLIA Nervous system Nervous system diseases 

分 类 号：R741[医药卫生—神经病学与精神病学]