NG2 Glia:The Guardians Against Prion‑induced Neurotoxicity Through Prostaglandin E2 Blockade  

作　　者：Shu Feng Emily Parker Timon Cheng‑Yi Liu Luodan Yang 

机构地区：[1]School of Physical Education and Sports Science,South China Normal University,Guangzhou 510006,China [2]Medical College of Georgia at Augusta University,Augusta 30909,USA

出　　处：《Neuroscience Bulletin》2025年第3期539-542,共4页神经科学通报(英文版)

基　　金：supported by the National Natural Science Foundation of China(32300959);a Guangzhou Scientific Research Grant(SL2024A04J00578);the SCNU Young Faculty Development Program(22KJ04).

摘　　要：Neuron glia antigen-2(NG2)glia,also known as oligodendrocyte precursor cells(OPCs),are essential for maintaining the normal function and structure of the central nervous system(CNS)due to their supportive role[1].Under physiological conditions,NG2 glia are involved in myelination by differentiating into oligodendrocytes,which are responsible for forming the myelin sheath around axons[2].In addition,the NG2 glia can directly influence the activity of neuronal circuits by receiving synaptic input from neurons and generating action potentials[3].Under pathological conditions,such as in response to injury or disease,the NG2 glia proliferate and differentiate to replace damaged oligodendrocytes,contributing to the repair and regeneration of myelin[4].

关 键 词：maintaining normal function structure myelin sheath axons oligodendrocyte precursor cells opcs receiving synaptic input neurons NEUROTOXICITY PRION central nervous system cns due ng glia 

分 类 号：R741[医药卫生—神经病学与精神病学]