云南高校图书馆联盟文献共享服务平台- PRION

PRION: 作品数：173被引量：154H指数：5; 导出分析报告; 相关领域：医药卫生生物学更多>>; 相关作者：朱钦士赵德明周筠梅练富林柯莎更多>>; 相关机构：中国农业大学中国科学院南加州大学厦门大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划中国科学院知识创新工程重要方向项目更多>>

Therapeutic targeting of cellular prion protein: toward the development of dual mechanism anti-prion compounds: 《Neural Regeneration Research》2025年第4期1009-1014,共6页Antonio Masone Chiara Zucchelli Enrico Caruso Giovanna Musco Roberto Chiesa; supported by Telethon Italy award GGP15225(to RC and GM);Italian Ministry of Health award RF-2016-02362950(to RC and CZ);the CJD Foundation USA(to RC);the Associazione Italiana Encefalopatie da Prioni(AIEnP)(to RC).; PrPSc,a misfolded,aggregation-prone isoform of the cellular prion protein(PrPC),is the infectious prion agent responsible for fatal neurodegenerative diseases of humans and other mammals.PrPSccan adopt different patho...; 关键词：anti-prion drug anti-PrPC antibody antisense oligonucleotide NEURODEGENERATION pharmacological chaperone porphyrin prion disease PrPC degrader PrPC shedding zinc finger repressor

Activation of IP10/CXCR3 Signaling is Highly Coincidental with PrP^(Sc)Deposition in the Brains of Scrapie-Infected Mice: 《Biomedical and Environmental Sciences》2024年第11期1235-1251,共17页Chen Jia Chen Cao Hu Chao Yang Wei Wang Lin Chen Dongdong Wu Yuezhang Shi Qi Dong Xiaoping; supported by SKLID Development Grants(2021SKLID504,2019SKLID401,2019SKLID603,and 2016SKLID603);the National Natural Science Foundation of China(81772197,81401670,and 81630062)。; Objective To analyze the relationship between Chemokine IP10 and its receptor CXCR3 during prion infection.Methods We investigated the increases in IP10 signals,primarily localized in neurons within the brains of scra...; 关键词：PRION Chemokine IP10 CXCR3 ACTIVATION

Classical bovine spongiform encephalopathy and chronic wasting disease:two sides of the prion coin: 《Animal Diseases》2024年第1期1-18,共18页Nicholas J.Haley Juergen A.Richt; funded in part by the Center on Emerging and Zoonotic Infectious Diseases(CEZID)of the National Institutes of General Medical Sciences underaward number P20GM130448.; Transmissible spongiform encephalopathies(TSEs)are a group of progressive and ultimately fatal neurologic diseases of man and animals,all resulting from the propagated misfolding of the host's normal cellular prion pr...; 关键词：PRION Bovine Spongiform Encephalopathy Chronic Wasting Disease TRANSMISSION PATHOGENESIS ZOONOSIS

Decoding the Cellular Trafficking of Prion-like Proteins in Neurodegenerative Diseases: 《Neuroscience Bulletin》2024年第2期241-254,共14页Chenjun Hu Yiqun Yan Yanhong Jin Jun Yang Yongmei Xi Zhen Zhong; supported by the National Natural Science Foundation of China(82071424);the Zhejiang University Education Foundation Global Partnership Fund(188170+194452115/011).; The accumulation and spread of prion-like proteins is a key feature of neurodegenerative diseases(NDs)such as Alzheimer’s disease,Parkinson's disease,or Amyotrophic Lateral Sclerosis.In a process known as‘seeding’,...; 关键词：Neurodegenerative diseases Prion-like propagation SEEDING ENDOCYTOSIS Endolyosomal leaking Degradation

Protein amyloid aggregate:Structure and function被引量：2: 《Aggregate》2023年第4期55-70,共16页Qianhui Xu Yeyang Ma Yunpeng Sun Dan Li Xin Zhang Cong Liu; National Natural Science Foundation(NSF)of China,Grant/Award Numbers:82188101,32171236,31872716,32170683;the Science and Technology Commission of Shanghai Municipality(STCSM),Grant/Award Numbers:20XD1425000,2019SHZDZX02;the Shanghai Pilot Program for Basic Research–Chinese Academy of Science,Shanghai Branch,Grant/Award Number:CYJ-SHFY-2022-005。; Protein amyloid aggregation has been widely observed to occur and plays impor-tant roles in both physiological processes and pathological diseases.Remarkably,amyloid aggregates assembled by native proteins gain a vari...; 关键词：amyloidfibril neurodegenerative diseases prion-like propagation protein phase separation protein aggregate

Establishment of a Special Platform for the Research of Prion and the Diagnosis of Human Prion Disease —China’s Studies: 《China CDC weekly》2022年第33期729-734,共6页Kang Xiao Qi Shi Cao Chen Wei Zhou Chen Gao Liping Gao Jun Han Jichun Wang Xiaoping Dong; Supported by SKLID Development Grant(2021SKLID506,2019SKLID501,2019SKLID603,2021SKLID101);National Natural Science Foundation of China(81572048).; The studies of prions and prion disease usually need many special platforms and techniques that differ from those for classical microbes.Search of new biomarkers and establishment of new methods for the diagnosis of h...; 关键词：HUMAN DIAGNOSIS PRION

Extensive Disturbances of Intracellular Components and Dysfunctions of Biological Pathways in the Brain Tissues During Prion Infection—China’s Studies: 《China CDC weekly》2022年第33期741-747,共7页Qi Shi Cao Chen Kang Xiao Wei Zhou Chen Gao Liping Gao Jun Han Jichun Wang Xiaoping Dong; Supported by National Key R&D Program of China(2020YFE0205700);SKLID Development Grant(2021SKLID503,2021SKLID504,2019SKLID401);National Natural Science Foundation of China(81772197,81630062,81401670).; The study describes some of the major findings of changes in intracellular components and biological pathways in the brain during prion infection and hypothesizes some important physiological and pathological approach...; 关键词：alterations HOMEOSTASIS summarized

Global Profiles of Acetylated Proteins in Brains of Scrapie Agents 139A- and ME7-Infected Mice Collected at Mid-Early, Mid-Late, and Terminal Stages: 《Biomedical and Environmental Sciences》2022年第8期722-734,共13页SHI Qi CHEN Dong Dong ADALATI Maimaitiming XIAO Kang GAO Li Ping YANG Xue Hua WU Yue Zhang CHEN Cao DONG Xiao Ping; supported by National Key R&D Program of China [2020YFE0205700];Chinese National Natural Science Foundation Grants [81630062];grants from the State Key Laboratory for Infectious Disease Prevention and Control(China CDC)[Grant Nos.2019SKLID501,2019SKLID603,and 2019SKLID307]; Objective To describe the global profiles of acetylated proteins in the brains of scrapie agents 139Aand ME7-infected mice collected at mid-early,mid-late,and terminal stages.Methods The acetylated proteins from the c...; 关键词：PRION Scrapie-infected mouse Acetylation Proteomics Kyoto Encyclopedia of Genes and Genomes pathway

Astrocyte in prion disease: a double-edged sword被引量：2: 《Neural Regeneration Research》2022年第8期1659-1665,共7页Waqas Tahir Simrika Thapa Hermann M.Schatzl; supported by grants from Alberta Innovates/Alberta Prion Research Institute(APRI grants 201600010 and 201900008)(to HMS);ST had received a University of Calgary Eyes High,Killam and Alberta Innovates Health Solution(AIHS)doctoral fellowship.; Prion diseases are infectious protein misfolding disorders of the central nervous system that result from misfolding of the cellular prion protein(PrPC)into the pathologic isoform PrPSc.Pathologic hallmarks of prion d...; 关键词：Alzheimer’s disease ASTROCYTES central nervous system Creutzfeldt-Jakob disease glial cells NEURODEGENERATION PRION prion disease prion protein SCRAPIE

朊样蛋白Doppel的研究进展: 《中国预防兽医学报》2022年第6期676-681,共6页王川俞海山杨宇泽魏亚琴张钊万学瑞贾晓蕊吴润; 国家自然科学基金(32060822、31500067);甘肃省科技计划项目重点研发计划(18YF1NA077);甘肃农业大学动物医学院学科建设基金(GSAU-XKJS-2018-074)。; 传染性海绵状脑病(Transmissible spongiform encephalopathies,TSEs)是由朊蛋白(Prion protein,PrP)引起的一种致命的神经退行性疾病,最早于18世纪中期在欧洲地区羊群中发现羊瘙痒病,目前已在人和多种哺乳动物发现了传染性海绵状脑病...; 关键词：传染性海绵状脑病朊蛋白痒病神经退行性疾病 PRION PrP 错误折叠

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