EPIGENETIC

作品数：398被引量：1463H指数：16
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相关领域：医药卫生生物学更多>>
相关作者：王锐王从义班冬梅白元鹏苏建忠更多>>
相关机构：华中科技大学信息科学与技术学院哈尔滨工业大学北京大学更多>>
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Transient chemical-mediated epigenetic modulation confers unrestricted lineage potential on human primed pluripotent stem cells
《Science China(Life Sciences)》2025年第4期1084-1101,共18页Shi Chen Yuanyuan He Lejun Lv Bei Liu Cheng Li Hongkui Deng Jun Xu 
supported by the National Key Research and Development Program of China(2021YFA1100300);the National Natural Science Foundation of China(32288102,32370843 and 32025006)Part of the data analysis was performed on the High Performance Computing Platform of the Center for Life Sciences,Peking University。
Human primed pluripotent stem cells are capable of generating all the embryonic lineages.However,their extraembryonic trophectoderm potentials are limited.It remains unclear how to expand their developmental potential...
关键词：trophectoderm lineages human primed pluripotent stem cells epigenetic regulation small molecules 
Investigating Müller glia reprogramming in mice: a retrospective of the last decade, and a look to the future
《Neural Regeneration Research》2025年第4期946-959,共14页Zhiyuan Yin Jiahui Kang Xuan Cheng Hui Gao Shujia Huo Haiwei Xu 
supported by the National Natural Science Foundation of China,No.31930068;National Key Research and Development Program of China,Nos.2018YFA0107302 and 2021YFA1101203(all to HX).
Müller glia,as prominent glial cells within the retina,plays a significant role in maintaining retinal homeostasis in both healthy and diseased states.In lower vertebrates like zebrafish,these cells assume responsibi...
关键词：cell fusion chemical small-molecules EPIGENETIC extracellular matrix immune metabolic MICE Müller glia neurodegenerative diseases REPROGRAMMING retina regeneration 
A convenient research strategy for functional verification of epigenetic regulators during spermatogenesis
《Asian Journal of Andrology》2025年第2期261-267,共7页Shan Li Ying Yuan Ke-Yu Zhang Yi-Dan Guo Lu-Tong Wang Xiao-Yuan Zhang Shu Zhang Qi Yan Rong Zhang Jie Chen Feng-Tang Yang Jing-Rui Li 
financially supported by the Shandong Provincial Natural Science Foundation(No.ZR2021QC182).
Spermatogenesis is a fundamental process that requires a tightly controlled epigenetic event in spermatogonial stem cells(SSCs).The mechanisms underlying the transition from SSCs to sperm are largely unknown.Most stud...
关键词：JMJD1A JMJD2C H3K9me2 SPERMATOGENESIS spermatogonial stem cell 
Roles of autophagy and long non-coding RNAs in gastric cancer
《World Journal of Gastroenterology》2025年第11期198-206,共9页Thang Viet Luong Mai Thi Thu Cao Nam Van Duc Nguyen Hai Nguyen Ngoc Dang Trung Tran Nguyen 
Gastric cancer(GC)is one of the most aggressive malignancies worldwide and is characterized by its poor prognosis and resistance to conventional therapies.Autophagy and long non-coding RNAs(lncRNAs)play critical yet c...
关键词：AUTOPHAGY Gastrointestinal cancer Gastric cancer Long non-coding RNAs Cancer progression EPIGENETIC 
Dietary modulation of epigenetics:Implications for cancer prevention and progression
《Journal of Nutritional Oncology》2025年第1期8-15,共8页Si-Rui Zhu Xin-Yu Liang Qian Bai Xiang-Min Ni Jian Wang 
Epidemiological studies indicate a strong correlation between various types of human cancer and dietary factors,whereas the specific mechanisms remain to be fully elucidated.Epigenetic alterations,such as DNA methylat...
关键词：EPIGENETIC DNA methylation Histone modification Cancer DIET 
Integrated multi-omics reveals contrasting epigenetic patterns in leaf and root morphogenesis in Aegilops speltoides
《The Crop Journal》2025年第1期292-298,共7页Lingfeng Miao Zhe Chen Lifeng Gao Jizeng Jia Weilong Guo Guangyao Zhao 
supported by the National Key Research and Development Program of China(2023YFD1200403).
Aegilops speltoides,the closest ancestor of the wheat B subgenome,has been well studied genomically.However,the epigenetic landscape of Ae.speltoides and the effects of epigenetics on its growth and development remain...
关键词：Aegilops speltoides DNA methylation Histone modification Transcriptional regulatory network 
New perspectives on DNA methylation modifications in ocular diseases
《International Journal of Ophthalmology(English edition)》2025年第2期340-350,共11页Fei-Fei Zong Da-Dong Jia Guang-Kun Huang Meng Pan Hao Hu Shi-Yi Song Liang Xiao Ru-Weng Wang Liang Liang 
The methylation of DNA is a prevalent epigenetic modification that plays a crucial role in the pathological progression of ocular diseases.DNA methylation can regulate gene expression,thereby affecting cell function a...
关键词：DNA methylation modification EPIGENETIC GLAUCOMA RETINOBLASTOMA diabetic retinopathy methylase inhibitors 
The impact of endocrine-disrupting chemicals on stem cells:Mechanisms and implications for human health
《Journal of Environmental Sciences》2025年第1期294-309,共16页Juan P.Munoz 
supported by the National Research and Development Agency of Chile(ANID)and the National Fund for Scientific and Technological Development(FONDECYT)of the gobernment of Chile(FONDECYT No.11231072).
Endocrine-disrupting chemicals(EDCs)are compounds,either natural or man-made,that interferewith the normal functioning of the endocrine system.There is increasing evidence that exposure to EDCs can have profound adver...
关键词：Endocrine-disrupting chemicals Stem cells Cancer stem cells EPIGENETIC HORMONES 
LKB1 inactivation promotes epigenetic remodeling-induced lineage plasticity and antiandrogen resistance in prostate cancer
《Cell Research》2025年第1期59-71,共13页Fei Li Pengfei Dai Huili Shi Yajuan Zhang Juan He Anuradha Gopalan Dan Li Yu Chen Yarui Du Guoliang Xu Weiwei Yang Chao Liang Dong Gao 
supported by the National Science Fund for Distinguished Young Scholars(32125013);the Excellent Young Scholars Fund(82422052);the National Natural Science Foundation of China(92253304,82002718,92357301,92253305,82461160322);the National Key R&D Program of China(2023YFC2506401);the Jiangsu Natural Science Foundation(BK20191077);the China National Postdoctoral Program for Innovative Talents(BX2021306,BX2024370);the Shanghai Oriental Talent Program,Shanghai Science and Technology Development Funds(22QA1409900,23ZR1470100);Shanghai Municipal Science and Technology Major Project,the Sanofi Scholarship and Heaye Program.
Epigenetic regulation profoundly influences the fate of cancer cells and their capacity to switch between lineages by modulating essential gene expression,thereby shaping tumor heterogeneity and therapy response.In ca...
关键词：LKB1 INACTIVATION PLASTICITY 
Lipophagy and epigenetic alterations are related to metabolic dysfunction-associated steatotic liver disease progression in an experimental model
《World Journal of Hepatology》2024年第12期1468-1479,共12页Felipe Schütz Larisse Longo Melina Belén Keingeski Eduardo Filippi-Chiela Carolina Uribe-Cruz Mário Reis Álvares-da-Silva 
Supported by Financiamento e IncentivoàPesquisa from Hospital de Clínicas de Porto Alegre,No.2022-0117(toÁlvares-da-Silva MR);National Council for Scientific and Technological Development,No.CNPq(to Alvares-da-Silva MR);Coordination for the Improvement of Higher Education Personnel,No.CAPES/PNPD.
BACKGROUND Genetic and epigenetic alterations are related to metabolic dysfunction-associated steatotic liver disease(MASLD)pathogenesis.AIM To evaluate micro(mi)RNAs and lipophagy markers in an experimental model of ...
关键词：Animal model EPIGENETIC Lipophagy MicroRNAs Metabolic dysfunction-associated steatotic liver disease Metabolic dysfunction-associated steatohepatitis 
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