Roles of autophagy and long non-coding RNAs in gastric cancer  

作　　者：Thang Viet Luong Mai Thi Thu Cao Nam Van Duc Nguyen Hai Nguyen Ngoc Dang Trung Tran Nguyen 

机构地区：[1]Department of Internal Medicine,University of Medicine and Pharmacy,Hue University,Hue 530000,Viet Nam [2]Department of Biochemistry,University of Medicine and Pharmacy,Hue University,Hue 530000,Viet Nam [3]Faculty of Medicine,Duy Tan University,Da Nang 550000,Viet Nam [4]Department of Biotechnology,NTT Hi-Tech Institute,Nguyen Tat Thanh University,Ho Chi Minh City 700000,Viet Nam

出　　处：《World Journal of Gastroenterology》2025年第11期198-206,共9页世界胃肠病学杂志(英文)

摘　　要：Gastric cancer(GC)is one of the most aggressive malignancies worldwide and is characterized by its poor prognosis and resistance to conventional therapies.Autophagy and long non-coding RNAs(lncRNAs)play critical yet complex roles in GC,functioning as both tumor suppressors and promoters depending on the disease stage and context.Autophagy influences cellular homeostasis and metabolism,whereas lncRNAs regulate gene expression through epigenetic modifications,RNA sponging,and protein interactions.Notably,the interplay between lncRNAs and autophagy modulates tumor progression,metastasis,chemoresistance,and the tumor microenvironment.This study explored the intricate relationship between lncRNAs and autophagy in GC,highlighting their roles in pathogenesis and treatment resistance.By addressing current knowledge gaps and proposing innovative therapeutic strategies,we have emphasized the potential of targeting this dynamic interplay for improved diagnostic and therapeutic outcomes.

关 键 词：AUTOPHAGY Gastrointestinal cancer Gastric cancer Long non-coding RNAs Cancer progression EPIGENETIC 

分 类 号：R73[医药卫生—肿瘤]