The impact of endocrine-disrupting chemicals on stem cells:Mechanisms and implications for human health  

作　　者：Juan P.Munoz 

机构地区：[1]Laboratorio de Bioquímica,Departamento de Química,Facultad de Ciencias,Universidad de Tarapacá,Arica 1000007,Chile

出　　处：《Journal of Environmental Sciences》2025年第1期294-309,共16页环境科学学报(英文版)

基　　金：supported by the National Research and Development Agency of Chile(ANID)and the National Fund for Scientific and Technological Development(FONDECYT)of the gobernment of Chile(FONDECYT No.11231072).

摘　　要：Endocrine-disrupting chemicals(EDCs)are compounds,either natural or man-made,that interferewith the normal functioning of the endocrine system.There is increasing evidence that exposure to EDCs can have profound adverse effects on reproduction,metabolic disorders,neurological alterations,and increased risk of hormone-dependent cancer.Stem cells(SCs)are integral to these pathological processes,and it is therefore crucial to understand how EDCs may influence SC functionality.This review examines the literature on different types of EDCs and their effects on various types of SCs,including embryonic,adult,and cancer SCs.Possiblemolecular mechanisms through which EDCs may influence the phenotype of SCs are also evaluated.Finally,the possible implications of these effects on human health are discussed.The available literature demonstrates that EDCs can influence the biology of SCs in a variety of ways,including by altering hormonal pathways,DNA damage,epigenetic changes,reactive oxygen species production and alterations in the gene expression patterns.These disruptions may lead to a variety of cell fates and diseases later in adulthood including increased risk of endocrine disorders,obesity,infertility,reproductive abnormalities,and cancer.Therefore,the review emphasizes the importance of raising broader awareness regarding the intricate impact of EDCs on human health.

关 键 词：Endocrine-disrupting chemicals Stem cells Cancer stem cells EPIGENETIC HORMONES 

分 类 号：X171.5[环境科学与工程—环境科学]