K^(+) channel-mediated retarded maturation of interneurons and its role in neurodevelopmental disorders  

作　　者：Kaizhen Li Daria Savitska Olga Garaschuk 

机构地区：[1]Laboratory of Systems Neuroscience,Department of Physiology,University of Bern,Bern,Switzerland [2]Institute of Physiology,Department of Neurophysiology,Eberhard Karls University of Tübingen,Tübingen,Germany

出　　处：《Neural Regeneration Research》2024年第7期1403-1404,共2页中国神经再生研究（英文版）

基　　金：supported by the German Research Foundation DFG grant GA 654/13-2 to OG。

摘　　要：De novo mutations in genes encoding K^(+)channels are implicated in many severe neurodevelopmental disorders.Specifically,mutations in KCNA2,encoding the Shaker-type voltage-gated K^(+)channel Kv1.2,and KCNJ2,encoding the inwardly rectifying K^(+)channel Kir2.1,associate with focal and generalized epilepsies,brain atrophy,autism,ataxia and hereditary spastic paraplegia(Syrbe et al.,2015;Masnada et al.,2017;Cheng et al.,2021).

关 键 词：DISORDERS ATROPHY 

分 类 号：R741[医药卫生—神经病学与精神病学]