云南高校图书馆联盟文献共享服务平台- PHENYTOIN

PHENYTOIN: 作品数：25被引量：20H指数：2; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：竟永华李行郭剑非吴体成杨健全更多>>; 相关机构：辛辛那提大学川北医学院巴中市人民医院更多>>; 相关期刊：《Asian pacific Journal of Reproduction》《Case Reports in Clinical Medicine》《Acta Pharmacologica Sinica》《Pharmacology & Pharmacy》更多>>; 相关基金：国家自然科学基金更多>>

Development of Extraction and Detection Method for a Chemotherapeutic Drug with Phenytoin in Biological Samples: 《Advances in Biological Chemistry》2024年第4期103-110,共8页Michael Arnot Nicolas Brice Adan Garcia Victor Lomeli My Phuong Vu Karno Ng; Dexamethasone is classified as a corticosteroid and is commonly used among cancer patients to decrease the amount of swelling around the tumor. Among patients with cancer, in particular brain tumors, seizures can beco...; 关键词：DEXAMETHASONE PHENYTOIN CANCER Drug Interaction Solid Phase Extraction

Pregnenolone 16α-carbonitrile negatively regulates hippocampal cytochrome P450 enzymes and ameliorates phenytoin-induced hippocampal neurotoxicity: 《Journal of Pharmaceutical Analysis》2023年第12期1510-1525,共16页Shuai Zhang Tingting Wang Ye Feng Fei Li Aijuan Qu Xiuchen Guan Hui Wang Dan Xu; supported in part by grants from the National Natural Science Foundation of China(Grant Nos.:81973405,82122071,and 82030111)to Dan Xu;Hui Wang,the National Key R&D Program of China(Grant No.:2020YFA0803900)to Hui Wang;the Hubei Provincial Natural Science Foundation Outstanding Youth Found,China(Grant No.:2022CFA083).; The central nervous system is susceptible to the modulation of various neurophysiological processes by the cytochrome P450 enzyme(CYP),which plays a crucial role in the metabolism of neurosteroids.The antiepileptic dr...; 关键词：Pregnenolone 16a-carbonitrile Pregnane X receptor Hippocampus Glucocorticoid receptor Phenytoin sodium NEUROTOXICITY

Effect of Cyclooxygenase Inhibition on P-Glycoprotein Expression and Phenytoin Level in Brain Tissue of Pilocarpine Induced Epilepsy in Rats: 《Journal of Biosciences and Medicines》2023年第8期169-191,共23页Reham M. Elsayed Amira S. Mohamed Mona K. Tawfik Magda M. Hagras; Background: Increased brain P-glycoprotein (P-gp) expression may play important role in resistance to antiseizure drugs. The present work aimed to overcome the drug resistance that develop due to overexpression of P-g...; 关键词：P-GLYCOPROTEIN Glutamate PHENYTOIN INDOMETHACIN CELECOXIB EPILEPSY

SCN8A epileptic encephalopathy mutations display a gain-of-function phenotype and divergent sensitivity to antiepileptic drugs被引量：1: 《Acta Pharmacologica Sinica》2022年第12期3139-3148,共10页Qian-bei Guo Li Zhan Hai-yan Xu Zhao-bing Gao Yue-ming Zheng; This work was supported by the National Science Fund for Distinguished Young Scholars(81825021);the National Natural Science Foundation of China(81773707);the Youth Innovation Promotion Association of the Chinese Academy of Sciences(2020284);the Fund of Science and Technology Commission of Shanghai Municipality(19431906000).; De novo missense mutations in SCN8A gene encoding voltage-gated sodium channel NaV1.6 are linked to a severe form of early infantile epileptic encephalopathy named early infantile epileptic encephalopathy type13(EIEE1...; 关键词：early infantile epileptic encephalopathy type 13 SCN8A gain-of-function mutation antiepileptic drugs PHENYTOIN CARBAMAZEPINE