INDOMETHACIN

作品数：84被引量：263H指数：10
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相关领域：医药卫生更多>>
相关作者：吴宝剑魏秀莉吴伟卢懿靳亚峰更多>>
相关机构：空军军医大学（第四军医大学）复旦大学中山医学大学中国医学科学院更多>>
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相关基金：国家自然科学基金广东省自然科学基金国家重点基础研究发展计划美国中华医学基金会项目更多>>
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Indomethacin restrains cytoplasmic nucleic acid-stimulated immune responses by inhibiting the nuclear translocation of IRF3
《Journal of Molecular Cell Biology》2024年第4期45-56,共12页Miao Wang Xiao-Wei Li Sen-Chao Yuan Jie Pan Zeng-Lin Guo Li-Ming Sun Shao-Zhen Jiang Ming Zhao Wen Xue Hong Cai Lin Gu Dan Luo Ling Chen Xue-Qing Zhou Qiu-Ying Han Jin Li Tao Zhou Tian Xia Tao Li 
supported by grants from the National Natural Science Foundation of China(82001690 to H.C.;81925017 and 82130052 to T.L.);the National Key Research and Development Program of China(2020YFA0707703 to T.Z.and 2020YFA0707702 to T.L.).
The recognition of cytosolic nucleic acid triggers the DNA/RNA sensor–IRF3 axis-mediated production of type I interferons(IFNs),which are essential for antiviral immune responses.However,the inappropriate activation ...
关键词：INDOMETHACIN IRF3 nuclear translocation autoimmune diseases 
Pulmonary endothelium-targeted nanoassembly of indomethacin and superoxide dismutase relieves lung inflammation被引量：1
《Acta Pharmaceutica Sinica B》2023年第11期4607-4620,共14页Yi Yang Makhloufi Zoulikha Qingqing Xiao Feifei Huang Qi Jiang Xiaotong Li Zhenfeng Wu Wei He 
supported by the National Natural Science Foundation of China,China (Nos.81872823,82073782 and 82241002);the Shanghai Science and Technology Committee,China (No.19430741500);the Key Laboratory of Modern Chinese Medicine Preparation of Ministry of Education of Jiangxi University of Traditional Chinese Medicine,China (zdsys202103)。
Lung inflammation is an essential inducer of various diseases and is closely related to pulmonary-endothelium dysfunction.Herein,we propose a pulmonary endothelium-targeted codelivery system of anti-inflammatory indom...
关键词：Codelivery NANOCRYSTALS Superoxide dismutase INDOMETHACIN Pulmonary endothelium INFLAMMATION Acute lung injury 
Effect of Cyclooxygenase Inhibition on P-Glycoprotein Expression and Phenytoin Level in Brain Tissue of Pilocarpine Induced Epilepsy in Rats
《Journal of Biosciences and Medicines》2023年第8期169-191,共23页Reham M. Elsayed Amira S. Mohamed Mona K. Tawfik Magda M. Hagras 
Background: Increased brain P-glycoprotein (P-gp) expression may play important role in resistance to antiseizure drugs. The present work aimed to overcome the drug resistance that develop due to overexpression of P-g...
关键词：P-GLYCOPROTEIN Glutamate PHENYTOIN INDOMETHACIN CELECOXIB EPILEPSY 
Prophylaxis of posterior capsule opacification through autophagy activation with indomethacin-eluting intraocular lens被引量：3
《Bioactive Materials》2023年第5期539-550,共12页Xiaobo Zhang Jing Wang Jingwei Xu Wen Xu Yin Zhang Chenqi Luo Shuang Ni Haijie Han Xingchao Shentu Juan Ye Jian Ji Ke Yao 
This work was supported by the National Key Research and Development Program of China(Grant numbers 2020YFE0204400);National Natural Science Foundation of China(Grant numbers 82271063,82271064,52203190,82070939,and 22005265);Key Research and Development Project of Zhejiang Province(Grant number 2020C03035);Postdoctoral Science Foundation of China(Grant number 2020TQ0261);Fundamental Research Funds for the Central Universities(Grant number 2021FZZX003-01-03).
Posterior capsule opacification(PCO)is the most common long-term postoperative complication of cataract surgery,leading to secondary vision loss.Optimized intraocular lens(IOL)structure and appropriate pharmacological...
关键词：Posterior capsule opacification INDOMETHACIN AUTOPHAGY Drug-eluting IOLs Epithelial-mesenchymal transition 
Opinion on double strategy to fight against COVID-19:Vaccination and home treatment with non-steroidal anti-inflammatory drugs
《World Journal of Meta-Analysis》2023年第1期1-4,共4页Serafino Fazio Flora Affuso 
The goals of global vaccination are to control,eliminate,or eradicate infectious diseases in a sustainable way that strengthens public health systems.Although the use of vaccines is essential for the control of epidem...
关键词：VACCINATION Non-steroidal anti-inflammatory drugs COVID-19 Early Treatment INDOMETHACIN HOSPITALIZATIONS 
The combination of ciprofloxacin and indomethacin suppresses the level of inflammatory cytokines secreted by macrophages in vitro被引量：1
《Chinese Journal of Traumatology》2022年第6期379-388,共10页Ke Liu Jing Yu Yu Xia Lei-Ting Zhang Sui-Yan Li Jun Yan 
supported by Science and Technology Innovation Enhancement Project of Army Medical University(Third Military Medical University)(2019XYY22)。
Purpose:The combined use of antibiotics and anti-inflammatory medicine to manage bacterial endotoxin-induced inflammation following injuries or diseases is increasing.The cytokine level produced by macrophages plays a...
关键词：CIPROFLOXACIN INDOMETHACIN Inflammatory cytokines In vitro MACROPHAGES 
Rectal nonsteroidal anti-inflammatory drugs,glyceryl trinitrate,or combinations for prophylaxis of post-endoscopic retrograde cholangiopancreatography pancreatitis:A network meta-analysis被引量：2
《World Journal of Clinical Cases》2022年第22期7859-7871,共13页Qing-Qing Shi Guo-Xiu Huang Wei Li Jian-Rong Yang Xiao-Yi Ning 
BACKGROUND Acute pancreatitis is the most common and severe complication of endoscopic retrograde cholangiopancreatography(ERCP).Recent evidence suggests that combinations based on rectal nonsteroidal anti-inflammator...
关键词：Endoscopic retrograde cholangiopancreatography PANCREATITIS DICLOFENAC INDOMETHACIN NAPROXEN Glyceryl trinitrate 
Safety of rectal indomethacin(100 mg)for the prevention of post-ERCP pancreatitis in the Japanese population:A single-center prospective pilot study
《Hepatobiliary & Pancreatic Diseases International》2022年第4期406-408,共3页Kotaro Takeshita Satoshi Asai Naoki Fujimoto Takumi Ichinona Eisuke Akamine Mamoru Takenaka 
To the Editor:Endoscopic retrograde cholangiopancreatography(ERCP)causes adverse events;post-ERCP pancreatitis(PEP)is one of the frequent adverse events.Recently,the efficacy of rectal administration of non-steroidal ...
关键词：PREVENTION ERCP DRUGS 
The novel indomethacin derivative CZ-212-3 exerts antitumor effects on castration-resistant prostate cancer by degrading androgen receptor and its variants
《Acta Pharmacologica Sinica》2022年第4期1024-1032,共9页Hong Wang Zhe Chang Guo-di Cai Ping Yang Jiang-he Chen Shan-shu Yang Yin-feng Guo Ming-yu Wang Xue-hua Zheng Jin-ping Lei Pei-qing Liu De-peng Zhao Jun-jian Wang 
This research was supported by the National Natural Science Foundation of China (81872891, 21801260, 82003651 and 21971267);the Guangdong Natural Science Funds for Distinguished Young Scholar (No. 2019B151502016);the Guangzhou Science and Technology Basic Research Program (No. 202002020082);the National Major Special Projects for the Creation and Manufacture of New Drugs (2019ZX09301104);the Fundamental Research Funds for the Central Universities (No. 19ykzd23 and 2021qntd44).
Androgen receptor (AR) serves as a main therapeutic target for prostate cancer (PCa). However, resistance to anti-androgen therapy (SAT) inevitably occurs. Indomethacin is a nonsteroidal anti-inflammatory drug that ex...
关键词：castration-resistant prostate cancer (CRPC) indomethacin derivatives CZ-212-3 androgen receptor(AR) patient-derived xenograft model(PDX) 
Herb-drug interaction in the protective effect of Alpinia officinarum against gastric injury induced by indomethacin based on pharmacokinetic, tissue distribution and excretion studies in rats
《Journal of Pharmaceutical Analysis》2021年第2期200-209,共10页Xuguang Zhang Zhenrui Xie Xun Chen Junqiang Qiu Yinfeng Tan Xiaoliang Li Hailong Li Junqing Zhang 
financially supported by the National Natural Science Foundation of China (No. 81560721)。
Alpinia officinarum Hance of the Chinese traditional herb for the treatment of emesis, abdominal pain and diarrhea has been used to counteract gastric disease induced by indomethacin in rats without obvious side effec...
关键词：Alpinia officinarum Hance INDOMETHACIN Herb-drug interaction PHARMACOKINETICS Tissue distribution EXCRETION 
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