Dihydrofolate reductase (DHFR) is an enzyme that catalyzes the reduction of dihydrofolate (DHF) to tetrahydrofolate (THF). Chemotherapy drugs such as methotrexate help to slow the progression of cancer by limiting the...
supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB37020103 to Linfeng Sun);research funds from the Center for Advanced Interdisciplinary Science and Biomedicine of IHM,Division of Life Sciences and Medicine,University of Science and Technology of China(QYPY20220012 to S.T.);start-up funding from the University of Science and Technology of China and the Chinese Academy of Sciences(GG9100007007,KY9100000026,KY9100000051,KJ2070000079 to S.T.);the National Natural Science Foundation of China(31900885 to X.L.,31870732 to Linfeng Sun);the Natural Science Foundation of Anhui Province(2008085MC90 to X.L.,2008085J15 to Linfeng Sun);the Fundamental Research Funds for the Central Universities(WK9100000021 to S.T.,WK9100000031 to Linfeng Sun);and the USTC Research Funds of the Double First-Class Initiative(YD9100002016 to S.T.,YD9100002004 to Linfeng Sun).Linfeng Sun is supported by an Outstanding Young Scholar Award from the Qiu Shi Science and Technologies Foundation and a Young Scholar Award from the Cyrus Tang Foundation.
The phytohormone auxin plays central roles in many growth and developmental processes in plants.Development of chemical tools targeting the auxin pathway is useful for both plant biology and agriculture.Here we reveal...
BACKGROUND Acute pancreatitis is the most common and severe complication of endoscopic retrograde cholangiopancreatography(ERCP).Recent evidence suggests that combinations based on rectal nonsteroidal anti-inflammator...
Non-steroidal anti-inflammatory drugs’anti-pyretic and anti-inflammatory effects has led some individuals to theorize these medications may blunt core body temperature(Tc)increases during exercise.We utilized a doubl...
Using a double-blind,randomized and counterbalanced,cross-over design,we assessed naproxen's effects on gastrointestinal(GI)distress and performance in eleven volunteers(6 male,5 female).Participants completed 4 trial...
supported by grants from DBT NER (BT/ PR16164/NER/95/88/2015);DST PURSE-(Phase-Ⅱ)(PAC-JNU-DSTPURSE-462);UGC RNW,UGC SAP at the level of DRS-Ⅰ & Ⅱ,and UPE-Ⅱ,JNU(Project Id No. 247)
Naproxen(NP), a nonsteroidal anti-inflammatory drug(NSAID), is used for the treatment of common pain, inflammation and tissue damage. Genotoxicity testing of NP is of prime importance as it represents the largest grou...
the Guangdong Province Science and Technology Program Foundation(No.2013B040200029);2016 National Drug Evaluation Special Foundation of China and the National Natural Science Foundation of China(21375027,21335002,and 21427806).
Naproxen–β-cyclodextrin inclusion complex was prepared by the freeze-drying method and analyzed by IR,UV spectroscopy,X-ray diffractometry and differential scanning calorimetry.Phase solubility,dissolution and inclu...
AIM: To determine the efficacy of rectally administered naproxen for the prevention of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP).METHODS: This double-blind randomized control trial ...
Restorative materials in the new era aim to be “bio-active”, bio-functional and long-lasting. As a part of our continuous interest of developing functional dual action restorative materials capable of being “bio-ac...
Chitosan nanocapsules containing naproxen as an active ingredient were synthesized by ionic gelation method in presence of polyanion tripolyphosphate as a crosslinker. The morphology and diameter of the prepared chito...