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DHFR: 作品数：59被引量：67H指数：4; 导出分析报告; 相关领域：医药卫生生物学更多>>; 相关作者：李状阳志军张玮俞炜源刘志刚更多>>; 相关机构：军事医学科学院中国医学科学院北京协和医学院广西医科大学附属肿瘤医院北京大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家高技术研究发展计划国家科技重大专项黑龙江省杰出青年科学基金更多>>

重庆市输入性卵形疟原虫curtisi和wallikeri亚种分子特征分析: 《中国人兽共患病学报》2024年第9期814-822,共9页谭妍罗飞李志峰向尧许静茹蔡娇娇李迎丽; 国家卫健委寄生虫病原与媒介生物学重点实验室开放课题项目(No.NHCKFKT2022-09);重庆市自然科学基金项目(No.CSTB2022NSCQ-MSX0853)。; 目的为了解重庆市输入性卵形疟原虫curtisi和wallikeri亚种的分子特征,对卵形疟病例的卵形疟原虫Cox1、Cytb、Tra、Dhfr、K13基因位点多态性进行分析。方法回顾性分析2013-2023年确诊的卵形疟原虫感染患者血样,PCR扩增卵形疟原虫Cox1、C...; 关键词：输入性卵形疟 curtisi亚种 wallikeri亚种 Cox1 CYTB Tra DHFR K13

西达本胺靶向P21调控DHFR表达逆转T淋巴细胞白血病甲氨蝶呤耐药的初步探究: 《热带医学杂志》2024年第7期939-945,共7页梁铭吴泽霖卫凤桂杨艺邹亚伟; 广东省自然科学基金(2016A030313654);广东省医学科学技术研究基金(A2021162)。; 目的探究西达本胺(CDM)靶向P21调控二氢叶酸还原酶(DHFR)表达逆转T淋巴细胞白血病(T⁃ALL)甲氨蝶呤(MTX)的耐药机制,为T⁃ALL靶向治疗提供参考依据。方法将过表达载体(ov⁃DHFR)转染T⁃ALL细胞系Jurkat细胞,Western blot检测细胞中DHFR蛋白...; 关键词：急性淋巴细胞白血病 DHFR P21 MTX耐药增殖

Synthesis and Characterization of Naproxen-Salicylate Derivatives as Potential Dual-Targeted Inhibitors of Dihydrofolate Reductase: 《Advances in Biological Chemistry》2024年第4期87-102,共16页Syon Schlecht Emily Gunderson Ruthie Fowler Takara Aguilar; Dihydrofolate reductase (DHFR) is an enzyme that catalyzes the reduction of dihydrofolate (DHF) to tetrahydrofolate (THF). Chemotherapy drugs such as methotrexate help to slow the progression of cancer by limiting the...; 关键词：Dihydrofolate Reductase DHFR Chemotherapy Nonsteroidal Anti-Inflammatory Drugs NSAIDS Folate Metabolism Pathway Anti-Folate Novel Therapeutic Development

A single-domain protein catenane of dihydrofolate reductase被引量：1: 《National Science Review》2023年第11期123-132,共10页Jing Fang Tianzuo Li Jiyeon Lee Dahye Im Lianjie Xu Yajie Liu Jongcheol Seo Wen-Bin Zhang; supported by the National Key Research and Development Program of China(2020YFA0908100);the National Natural Science Foundation ofChina(21991132,21925102,92056118,22101010,22201016 and 22201017);the Beijing National Laboratory for Molecular Sciences(BNLMS-CXXM202006);the National Research Foundation of Korea(2019R1C1C1008414 and 2020R1A5A1019141)。; A single-domain protein catenane refers to two mechanically interlocked polypeptide rings that fold synergistically into a compact and integrated structure,which is extremely rare in nature.Here,we report a single-dom...; 关键词：cellular synthesis CATENANE protein domain chemical topology DHFR

Dihydrofolate reductase-like protein inactivates hemiaminal pharmacophore for self-resistance in safracin biosynthesis: 《Acta Pharmaceutica Sinica B》2023年第3期1318-1325,共8页Ning Shao Xueyang Ma Ying-Ying Zhang Donghui Yang Ming Ma Gong-Li Tang; supported by the National Natural Science Foundation of China(Nos.31930002,21621002,21877002,81991525,82273829 and 22077007);the key project at central government level:the ability establishment of sustainable use for valuable Chinese medicine resources(2060302-2201-17).; Dihydrofolate reductase(DHFR),a housekeeping enzyme in primary metabolism,has been extensively studied as a model of acid-base catalysis and a clinic drug target.Herein,we investigated the enzymology of a DHFR-like pr...; 关键词：Catalytic mechanism Crystal structure Dihydrofolate reductase(DHFR) Hemiaminal pharmacophoreSacH Safracin biosynthesis Self-resistance Tetrahydroisoquinoline(THIQ)alkaloids

Molecular docking of amphetamine,cathine and cathinone with dihydrofolate reductase:a computational analysis of inhibition of dihydrofolate reductase by khat alkaloids: 《Toxicology Communications》2022年第2期23-28,共6页Siddig Ibrahim Abdelwahab Abdullah Farasani Ahmed Jerah Manal Mohamed Elhassan Taha Anil Bidwai; Interaction of amphetamine,cathine and cathinone with the enzyme dihydrofolate reductase was studied by molecular docking using AutoDock 4.2 as the docking software application.AutoDock 4.2 software serves as a valid ...; 关键词：AMPHETAMINE cathine CATHINONE methotrexate docking AUTODOCK DHFR khat alkaloids

中缅边境地区恶性疟原虫dhfr和dhps基因多态性分析: 《中国病原生物学杂志》2022年第5期595-600,共6页叶升玉李春富唐烨榕叶润周红宁; 云南省重点研发计划项目(No.202103AQ100001);澜湄合作专项基金项目(No.2020399)。; 目的分析中缅边境地区恶性疟原虫dhfr和dhps基因多态性。方法收集2001-2012年中缅边境中国云南西双版纳州景洪市、缅甸克钦邦拉咱市和缅甸掸邦第二特区勐冒县恶性疟患者滤纸血样本175份,采用巢式PCR法分别扩增恶性疟原虫二氢叶酸还原...; 关键词：恶性疟原虫 pfdhfr基因 pfdhps基因多态性中缅边境地区

一种DHFR介导的可调控的腺嘌呤碱基编辑器的构建: 《现代生物医学进展》2021年第23期4401-4406,共6页刘舒彭凤段晓悦万晓玲罗学廷李潇飒; 国家自然科学基金项目(82000906)。; 目的:单碱基编辑器作为一种高效、精确、低脱靶的编辑系统,目前被广泛应用于生物体中。然而,Cas核酸酶本身的免疫原性具有引发机体免疫反应的潜在风险,可能阻碍其在基因治疗中的有效和安全使用。因而本研究旨在构建一种由DHFR介导的可...; 关键词：ABE DHFR 基因编辑

dhfr基因过表达对乙醇致斑马鱼胚胎心血管发育异常的效应研究被引量：2: 《中国当代儿科杂志》2020年第8期916-922,共7页孙淑娜蒋璆陆定桂永浩; 上海市科委自然科学基金(19ZR1406300)。; 目的观察二氢叶酸还原酶基因(dhfr)过表达对乙醇致斑马鱼胚胎心脏和血管发育异常的作用,并初步探讨其机制。方法体外转录dhfr mRNA并将其显微注射入斑马鱼受精卵内使dhfr基因过表达,并进行过表达的效率验证。将野生型斑马鱼分为正常对...; 关键词：dhfr基因乙醇心脏血管 NKX2.5 tbx1 FLK-1 斑马鱼

Syntheses and Antiproliferative Evaluation of 6-Thienyl, 6-Polyphenyl Aryl and 6-Naphthyl Derivatives of 2,4-Diaminopyrido [3,2-d] pyramidine as Non-classical Antifolate Targeting DHFR: 《Chemical Research in Chinese Universities》2017年第4期559-568,共10页YANG Jiajia WANG Meng LI Xia FAN Ningning XUE Liangmin LI Hao TIAN Chao WANG Xiaowei LIU Junyi ZHANG Zhili; Supported by the National Natural Science Foundation of China（Nos.21172014, 21302007）.; A series of 6-thienylethenyl, 6-polyphenyl arylethenyl, 6-thienylethyl and 6-polyphenyl arylethyl deriva- tives of 2,4-diaminopyrido[3,2-d]pyrimidine for targeting dihydrofolate reductase（DHFR） was designed and synt...; 关键词：Non-classical antifolate Dihydrofolate reductase（DHFR） Antitumor Antimicrobial

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