An acute naproxen dose does not affect core temperature or Interleukin-6 during cycling in a hot environment  

作　　者：Dawn M.Emerson Stephen CL.Chen Toni M.Torres-McGehee Craig E.Pfeifer Charles C.Emerson J.Mark Davis 

机构地区：[1]Department of Physical Therapy,Rehabilitation Science,and Athletic Training,School of Health Professions,University of Kansas Medical Center,3901 Rainbow Blvd,MS 2002,Kansas City,Kansas,66160,USA. [2]Division of Exercise and Sport Science,Bob Jones University,1700 Wade Hampton Blvd,Greenville,South Carolina,29614,USA. [3]Department of Exercise Science,Arnold School of Public Health,University of South Carolina,921 Assembly Street,Columbia,SC,29208,USA [4]Applied Sport and Exercise Sciences,The Park,University of Gloucestershire,Cheltenham GL502RH,United Kingdom. [5]Department of Athletics,5100 Rockhill Rd SRC 201,University of Missouri-Kansas City,Kansas City,Missouri,64110,USA.

出　　处：《Sports Medicine and Health Science》2021年第4期243-251,共9页运动医学与健康科学（英文）

摘　　要：Non-steroidal anti-inflammatory drugs’anti-pyretic and anti-inflammatory effects has led some individuals to theorize these medications may blunt core body temperature(Tc)increases during exercise.We utilized a double-blind,randomized,and counterbalanced cross-over design to examine the effects of a 24-h naproxen dose(3–220 mg naproxen pills)and placebo(0 mg naproxen)on Tc and plasma interleukin-6(IL-6)concentrations during cycling in a hot or ambient environment.Participants(n=11;6 male,5 female;age=27.8±6.5 years,weight=79.1±17.9 kg,height=177±9.5 cm)completed 4 conditions:1)placebo and ambient(Control);2)placebo and heat(Heat);3)naproxen and ambient(Npx);and 4)naproxen and heat(NpxHeat).Dependent measures were taken before,during,and immediately after 90 min of cycling and then 3 h after cycling.Overall,Tc significantly increased pre-(37.1±0.4℃)to post-cycling(38.2±0.3℃,F_(1.7,67.3)=150.5,p<0.001)and decreased during rest(37.0±0.3℃,F_(2.0,81.5)=201.6,p<0.001).Rate of change or maximum Tc were not significantly different between conditions.IL-6 increased pre-(0.54±0.06 pg/ml)to post-exercise(2.46±0.28 pg/ml,p<0.001)and remained significantly higher than pre-at 3 h post-(1.17±0.14 pg/ml,95%CI=-1.01 to-0.23,p=0.001).No significant IL-6 differences occurred between conditions.A 24-h,over-the-counter naproxen dose did not significantly affect Tc or IL-6 among males and females cycling in hot or ambient environments.

关 键 词：CYTOKINE Exertional heat illness NSAIDS THERMOREGULATION Exercise 

分 类 号：TG1[金属学及工艺—金属学]