Facile Preparation and Extensive Characterization of Naproxen–β-Cyclodextrin Inclusion Complex  

作　　者：Guiying Jin Hui Chen 

机构地区：[1]Guangdong Institute for Drug Control,Guangzhou 510180,People’s Republic of China [2]Department of Chemistry,Fudan University,Shanghai 200433,People’s Republic of China

出　　处：《Journal of Analysis and Testing》2017年第2期94-99,共6页分析检测（英文）

基　　金：the Guangdong Province Science and Technology Program Foundation(No.2013B040200029);2016 National Drug Evaluation Special Foundation of China and the National Natural Science Foundation of China(21375027,21335002,and 21427806).

摘　　要：Naproxen–β-cyclodextrin inclusion complex was prepared by the freeze-drying method and analyzed by IR,UV spectroscopy,X-ray diffractometry and differential scanning calorimetry.Phase solubility,dissolution and inclusion rate of the complex were determined.The phase solubility diagram was of the AL type,which revealed that the molar ratio of naproxen toβ-cyclodextrin was 1:1.The solubility of naproxen significantly increased with increasingβ-cyclodextrin concentration.The apparent stability constant,Kc,was calculated from the slope and intercept of the AL solubility diagram as 2376/M.The total released amount and released time of naproxen from the inclusion complex were better than that of the intact naproxen.

关 键 词：Β-CYCLODEXTRIN NAPROXEN Inclusion rate Complex XRD DSC 

分 类 号：O62[理学—有机化学]