CELECOXIB

作品数：180被引量：541H指数：12
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相关机构：华中科技大学哈尔滨医科大学中南大学中南大学湘雅二医院更多>>
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Effect of the Zushima patch combined with celecoxib on pain and inflammatory factor expression in knee osteoarthritis with cold-dampness obstruction
《iLABMED》2024年第4期286-293,共8页Yumin Yang Lijun Sun Zhao Peng Xiumin Li Yan Chen 
New Medical Emergency Requirement Demonstration,Grant/Award Number:LB2023B010100。
Background:Knee osteoarthritis(KOA)is a chronic degenerative joint dis-ease that frequently occurs in middle-aged and older individuals.Although celecoxib is a commonly used drug for the treatment of KOA,its efficacy ...
关键词：CELECOXIB cold-dampness obstruction type inflammatory factor knee osteoarthritis Zushima patch 
Efficacy and safety of Jiawei Simiao powder combined with celecoxib for acute gouty arthritis:A meta-analysis被引量：1
《Journal of Traditional Chinese Medical Sciences》2024年第3期283-292,共10页Weiyu Jia Maoying Wei Wenhua Zhang Dan Yin Yijia Jiang Churan Wang Xiangdong Wang Yutong Fei Yanbing Gong 
supported by the National Administration of Traditional Chinese Medicine Young Qi Huang Scholars support project.
Objective:To evaluate the efficacy and safety of Jiawei Simiao powder(JWSMP)combined with celecoxib for the treatment of acute gouty arthritis by conducting a meta-analysis of randomized controlled trials(RCTs).Method...
关键词：Jiawei Simiao powder CELECOXIB Acute gouty arthritis META-ANALYSIS 
An emerging terpolymeric nanoparticle pore former as an internal recrystallization inhibitor of celecoxib in controlled release amorphous solid dispersion beads:Experimental studies and molecular dynamics analysis
《Acta Pharmaceutica Sinica B》2024年第6期2669-2684,共16页Jamie Anne Lugtu-Pe Xuning Zhang Sako Mirzaie Hao Han R.Chang Nour AL-Mousawi Kuan Chen Yongqiang Li Anil Kane Daniel Bar-Shalom Xiao Yu Wu 
supported in part by an Ontario Research Fund-Research Excellence(ORF-RE)grant(Ontario,Canada)in partnership with Patheon by Thermo Fisher Scientific,Natural Sciences and Engineering Research Council(NSERC)of Canada Discovery Grant and Equipment Grants to Xiao Yu Wu,University of Toronto(Canada),Leslie Dan Faculty of Pharmacy Dean's Fund to Jamie Anne Lugtu-Pe,University of Toronto(Canada),Mitacs Accelerate Internship sponsored by Candoo Pharmatech Company Inc.to Xuning Zhang(Canada),NSERC CREATE ContRoL program support to Sako Mirzaie and Hao Han R.Chang(Canada),Ontario Graduate Scholarship(OGS)to Hao Han R.Chang(Canada),and Pharmaceutical Sciences graduate department scholarships to Hao Han R.Chang and Kuan Chen,University of Toronto(Canada).
Solid oral controlled release formulations feature numerous clinical advantages for drug candidates with adequate solubility and dissolution rate.However,most new chemical entities exhibit poor water solubility,and he...
关键词：Controlled release amorphous solid dispersion Poorly soluble drug Internal recrystallization Membrane-reservoir coated beads Molecular dynamics simulation Effect of pore formers Terpolymer nanogel Drug-polymer interactions 
Celecoxib enhances the response of tumor cells to cisplatin through upregulating PUMA in non–small cell lung cancer carrying wild-type p53
《Oncology and Translational Medicine》2024年第2期79-86,共8页Yuxuan Xiao Ziyu Wang Meng Gu Jinjing Tan Weiying Li 
the Beijing Municipal Science and Technology Commission(grant Z211100002921013);the Tongzhou District Science and Technology Committee Project to Tongzhou(grant KJ2020CX010).
Celecoxib,a cyclooxygenase-2 inhibitor,can enhance the efficacy of chemotherapy;however,its effect seems inconsistent.In this study,we investigated whether celecoxib would increase the antiproliferative effects of cis...
关键词：P53 CELECOXIB CISPLATIN Non-small cell lung cancer PUMA 
MK886和celecoxib对结肠癌HT-29细胞增殖的影响
《中国老年学杂志》2024年第3期691-696,共6页李仕宇 彭丹若 赵逵 
目的 探讨通过5-脂氧合酶(LOX)抑制剂MK886及环氧合酶(COX)-2抑制剂celecoxib阻断花生四烯酸途径对结肠癌HT-29细胞增殖的影响。方法 CCK-8及EdU法分别检测不同浓度的MK886(200.0、100.0、50.0、25.0、12.5μmol/L)和celecoxib(200.0、1...
关键词：MK886 CELECOXIB 结肠癌 
Rosmarinic acid in combination with ginsenoside Rg1 suppresses colon cancer metastasis via co-inhition of COX-2 and PD1/PD-L1 signaling axis被引量：4
《Acta Pharmacologica Sinica》2024年第1期193-208,共16页Huan Liu Rui Deng Cheng-wei Zhu Hong-kuan Han Gang-fan Zong Lang Ren Peng Cheng Zhong-hong Wei Yang Zhao Su-yun Yu Yin Lu 
supported by the National Natural Science Foundation of China(81973734,81961128020 and 82204802);the Jiangsu Specially Appointed Professorship Foundation(013038021001);the Postgraduate Research and Practice Innovation Programof Jiangsu Province(KYCX22_2014).
Metastasis of colorectal cancer(CRC)is a leading cause of mortality among CRC patients.Elevated COX-2 and PD-L1 expression in colon cancer tissue has been linked to distant metastasis of tumor cells.Although cox-2 inh...
关键词：colon cancer METASTASIS COX-2 MYO10 FILOPODIA rosmarinic acid ginsenoside Rg1 CELECOXIB PD-1/PD-L1 
Effect of Cyclooxygenase Inhibition on P-Glycoprotein Expression and Phenytoin Level in Brain Tissue of Pilocarpine Induced Epilepsy in Rats
《Journal of Biosciences and Medicines》2023年第8期169-191,共23页Reham M. Elsayed Amira S. Mohamed Mona K. Tawfik Magda M. Hagras 
Background: Increased brain P-glycoprotein (P-gp) expression may play important role in resistance to antiseizure drugs. The present work aimed to overcome the drug resistance that develop due to overexpression of P-g...
关键词：P-GLYCOPROTEIN Glutamate PHENYTOIN INDOMETHACIN CELECOXIB EPILEPSY 
Effects of individual shock wave therapy vs celecoxib on hip pain caused by femoral head necrosis被引量：3
《World Journal of Clinical Cases》2023年第9期1974-1984,共11页Jun-Yu Zhu Jun Yan Jian Xiao Hai-Guang Jia Hao-Jun Liang Geng-Yan Xing 
BACKGROUND Celecoxib has been used to treat hip discomfort and functional difficulties associated with osteonecrosis of the femoral head(ONFH),although significant adverse reactions often follow long-term use.Extracor...
关键词：Extracorporeal shockwave therapy Osteonecrosis of femoral head PAIN Magnetic resonance imaging three-dimensional reconstruction CELECOXIB 
Effect of celecoxib on improving depression:A systematic review and meta-analysis被引量：1
《World Journal of Clinical Cases》2022年第22期7872-7882,共11页Zhi Wang Qiao Wu Qing Wang 
Supported by the Sixth Batch of Wuhan Young and Middle-aged Medical Backbone Talents Training Project Wuhan Health and Family Planning Commission,No.[2018]116
BACKGROUND Anti-inflammation drugs were uncovered to be a potential therapy for depression.Celecoxib as a selective COX2 inhibitor is also one anti-inflammation drugs.Celecoxib is widely used in the clinic,which is we...
关键词：CELECOXIB DEPRESSION Systematic review META-ANALYSIS INFLAMMATION 
Preparation of solid pharmaceutical forms of celecoxib with immediate-release and sustained-release by using wet granulation techniques and evaluation of their in vitro characteristics
《Journal of Chinese Pharmaceutical Sciences》2022年第7期536-544,共9页Ahmed Alkhodri Svetlana Suslina 
supported by the Department of Pharmacy in the Peoples’Friendship University of Russia for providing all the required facilities。
In the present study,we aimed to formulate matrix tablets of celecoxib with immediate-release(IR)and sustained-release(SR)and evaluate the influence of different types and concentrations of polymers on drug release ch...
关键词：Immediate release Sustained release CELECOXIB HPMC Wet granulation Dissolution profile 
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