FILOPODIA

作品数：8被引量：20H指数：3
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相关领域：医药卫生生物学更多>>
相关作者：滕俊琳陈建国更多>>
相关机构：北京大学中国科学院上海生命科学研究院更多>>
相关期刊：《Mechanobiology in Medicine》《Science China(Life Sciences)》《Acta Pharmacologica Sinica》《Genes & Diseases》更多>>
相关基金：国家自然科学基金更多>>
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Probing the protrusions:lamellipodia and filopodia in cancer invasion and beyond
《Mechanobiology in Medicine》2024年第2期7-13,共7页Laras Pratiwi Elisa Elisa Henry Sutanto 
The dynamic protrusions of lamellipodia and filopodia have emerged as crucial players in tumor progression and metastasis.These membrane structures,governed by intricate actin cytoskeletal rearrangements,facilitate ca...
关键词：LAMELLIPODIA FILOPODIA Cancer invasion METASTASIS MECHANOBIOLOGY 
Rosmarinic acid in combination with ginsenoside Rg1 suppresses colon cancer metastasis via co-inhition of COX-2 and PD1/PD-L1 signaling axis被引量：3
《Acta Pharmacologica Sinica》2024年第1期193-208,共16页Huan Liu Rui Deng Cheng-wei Zhu Hong-kuan Han Gang-fan Zong Lang Ren Peng Cheng Zhong-hong Wei Yang Zhao Su-yun Yu Yin Lu 
supported by the National Natural Science Foundation of China(81973734,81961128020 and 82204802);the Jiangsu Specially Appointed Professorship Foundation(013038021001);the Postgraduate Research and Practice Innovation Programof Jiangsu Province(KYCX22_2014).
Metastasis of colorectal cancer(CRC)is a leading cause of mortality among CRC patients.Elevated COX-2 and PD-L1 expression in colon cancer tissue has been linked to distant metastasis of tumor cells.Although cox-2 inh...
关键词：colon cancer METASTASIS COX-2 MYO10 FILOPODIA rosmarinic acid ginsenoside Rg1 CELECOXIB PD-1/PD-L1 
Superresolution live-cell imaging reveals that the localization of TMEM106B to filopodia in oligodendrocytes is compromised by the hypomyelination-related D252N mutation
《Science China(Life Sciences)》2023年第8期1858-1868,共11页Shijia Xing Xiaolu Zheng Huifang Yan Yanquan Mo Ruoyu Duan Zhixing Chen Kunhao Wang Kai Gao Tongsheng Chen Shiqun Zhao Jingmin Wang Liangyi Chen 
supported by the National Natural Science Foundation of China(81925022,61827825,32227802,92054301);the Fundamental Research Center Project of the National Natural Science Foundation of China(T2288102);the National Science and Technology Major Project Program(2022YFC3400600);Beijing Natural Science Foundation Key Research Topics(Z20J00059);UMHS-PUHSC Joint Institute for Translational and Clinical Research(BMU2019JI009);Beijing Key Laboratory of Molecular Diagnosis and Study on Pediatric Genetic Diseases(BZ0317);China Postdoctoral Science Foundation(2021M690465)。
Hypomyelination leukodystrophies constitute a group of heritable white matter disorders exhibiting defective myelin development.Initially identified as a lysosomal protein,the TMEM106B D252N mutant has recently been a...
关键词：superresolution imaging OLIGODENDROCYTE TMEM106B LYSOSOME FILOPODIA 
The actin-bundling protein Fascin-1 modulates ciliary signalling
《Journal of Molecular Cell Biology》2023年第4期1-16,共16页Lena Brücker Stefanie Kornelia Becker Vanessa Maissl Gregory Harms Maddy Parsons Helen Louise May-Simera 
supported by grants from Johannes Gutenberg University Mainz,Alexander von Humboldt Foundation(Sofja Kovalevskaja Award),Hanns Seidel Foundation,and Sibylle Kalkhof-Rose Foundation.This project was further funded by Deutsche Forschungsgemeinschaft(DFG,German Research Foundation,GRK2526/1-Projectnr.407023052).
Primary cilia are microtubule-based cell organelles important for cellular communication. Since they are involved in the regulation of numerous signalling pathways, defects in cilia development or function are associa...
关键词：CILIA actin Wnt SIGNALLING CILIOPATHY Bardet–Biedl syndrome FILOPODIA 
PRR11 induces filopodia formation and promotes cell motility via recruiting ARP2/3 complex in non-small cell lung cancer cells被引量：2
《Genes & Diseases》2022年第1期230-244,共15页Zhili Wei Ru Wang Xun Yin lian Zhang Yunlong Lei Ying Zhang Yi Li Jiaqian Wu Youquan Bu Guoxiang Jin Chundong Zhang 
Filopodia, a finger-like structure and actin-rich plasma-membrane protrusion at the leading edge of the cell, has important roles in cell motility. However, the mechanisms of filopodia generation are not well-understo...
关键词：ARP2/3 complex Cell motility FAK FILOPODIA Focal adhesion INTEGRIN NSCLC cells PRR11 
Mutation inε-Sarcoglycan Induces a Myoclonus-Dystonia Syndrome-Like Movement Disorder in Mice被引量：1
《Neuroscience Bulletin》2021年第3期311-322,共12页Jiao Li Yiqiong Liu Qin Li Xiaolin Huang Dingxi Zhou Hanjian Xu Feng Zhao Xiaoxiao Mi Ruoxu Wang Fan Jia Fuqiang Xu Jing Yang Dong Liu Xuliang Deng Yan Zhang 
supported by National Natural Science Foundation of China(31630028,91632305,and 91632303);the Fund for Distinguished Young Scholars of National Natural Science Foundation of China(81425009 and 81425007);the National Basic Science Research Program of China(2012CB933900 and 2015CB755600);the Strategic Priority Research Program(B)of China(XDB02050500)。
Myoclonus dystonia syndrome(MDS)is an inherited movement disorder,and most MDS-related mutations have so far been found in theε-sarcoglycan(SGCE)coding gene.By generating SGCE-knockout(KO)and human 237 C>T mutation k...
关键词：SGCE MDS FILOPODIA SYNAPSE EXCITABILITY 
Differing and isoform-specific roles for the formin DIAPH3 in plasma membrane blebbing and filopodia formation被引量：6
《Cell Research》2012年第4期728-745,共18页Jana Stastna Xiaoyu Pan Haicui Wang Alina Kollmannsperger Stefan Kutscheidt Volker Lohmann Robert Grosse Oliver T Fackler 
Plasma membrane （PM） blebs are dynamic actin-rich cell protrusions that occur, e.g., during cytokinesis, amoeboid cell motility and cell attachment. Using a targeted siRNA screen against 21 actin nucleation factors,...
关键词：actin remodeling diaphanous formins plasma membrane blebbing FILOPODIA cell adhesion 
Effects of GSM 1800 MHz on dendritic development of cultured hippocampal neurons被引量：8
《Acta Pharmacologica Sinica》2007年第12期1873-1880,共8页Wei NING Shu-jun XU Huai CHIANG Zheng-ping XU Su-ya ZHOU Wei YANG Jian-hong LUO 
Project supported by the grants from National Natural Science Foundation of China(№ 50137030 and 30570440);the Natural Science Foundation of Zhejiang Province of China(Y205279)
Aim： To evaluate the effects of global system for mobile communications （GSM） 1800 MHz microwaves on dendritic filopodia, dendritic arborization, and spine maturation during development in cultured hippocampal neur...
关键词：global system for mobile communications microwaves dendritic filopodia dendriticarborization SPINES hippocampal neurons 
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