CILIA

作品数：74被引量：106H指数：6
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相关机构：首都医科大学军事医学科学院泸州医学院附属中医医院泸州医学院附属医院更多>>
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Congenital hydrocephalus:a review of recent advances in genetic etiology and molecular mechanisms
《Military Medical Research》2024年第6期942-958,共17页Xiu-Yun Liu Xin Song Marek Czosnyka Chiara Robba Zofia Czosnyka Jennifer Lee Summers Hui-Jie Yu Guo-Yi Gao Peter Smielewski Fang Guo Mei-Jun Pang Dong Ming 
supported by the National Key Research and Development Program of China(2021YFF1200602).
The global prevalence rate for congenital hydrocephalus(CH)is approximately one out of every five hundred births with multifaceted predisposing factors at play.Genetic influences stand as a major contributor to CH pat...
关键词：Congenital hydrocephalus Genetic disease Central system CILIA VENTRICLE 
ccdc141 is required for left-right axis development by regulating cilia formation in the Kupffer's vesicle of zebrafish
《Journal of Genetics and Genomics》2024年第9期934-946,共13页Pengcheng Wang Wenxiang Shi Sijie Liu Yunjing Shi Xuechao Jiang Fen Li Sun Chen Kun Sun Rang Xu 
supported by the National Natural Science Foundation of China(81970264).
Laterality is a crucial physiological process intricately linked to the cilium-centrosome complex during embryo development.Defects in the process can result in severe organ mispositioning.Coiled-coil domain containin...
关键词：Left-right axis CILIA WES Laterality defects ZEBRAFISH CCDC141 
A polarized multicomponent foundation upholds ciliary central microtubules
《Journal of Molecular Cell Biology》2024年第8期19-32,共14页Qingxia Chen Huijie Zhao Xinwen Pan Chuyu Fang Benhua Qiu Jingting Guo Xiumin Yan Xueliang Zhu 
supported by the National Natural Science Foundation of China(31991192,32230027,32270725,32100551,and 32270807);Shandong Natural Science Foundation(2022HWYQ-075).
Cilia’s back-and-forth beat pattern requires a central pair(CP)of microtubules.However,the mechanism by which the CP is upheld above the transition zone(TZ)remains unclear.Here,we showed that a rod-like substructure ...
关键词：basal plate central pair ciliary motility ependyma HYDROCEPHALUS motile cilia 
A commentary of“Rhythmic cilia changes support SCN neuron coherence in circadian clock”:Top 10 Scientific Advances of 2023,China
《Fundamental Research》2024年第3期695-696,共2页Wei Li Guangshuo Ou 
Primary cilia,microtubule-based cellular protrusions found on the surface of nearly all eukaryotic cells,serve as crucial signaling hubs[1].These antenna-like organelles play a pivotal role in perceiving environmental...
关键词：Primary INVOLVEMENT COLLECTIVE 
Super-Resolution Fluorescence Microscopy for Cilia Investigation and Ciliopathy Diagnosis(Invited)
《激光与光电子学进展》2024年第6期260-271,共12页Liu Zhen Wu Yang 
supported by the General Research Fund(GRF)from the Research Grants Council of Hong Kong(16100823,26101022)to Z.L.
The last two decades have witnessed the invention and development of super-resolution microscopy(SRM)that breaks the diffraction limit of light and pushes the fluorescence microscopy resolution to several nanometers.W...
关键词：DIAGNOSIS LIMIT SPITE 
Lack of CFAP54 causes primary ciliary dyskinesia in a mouse model and human patients
《Frontiers of Medicine》2023年第6期1236-1249,共14页Xinyue Zhao Haijun Ge Wenshuai Xu Chongsheng Cheng Wangji Zhou Yan Xu Junping Fan Yaping Liu Xinlun Tian Kai-Feng Xu Xue Zhang 
supported by the National Key Research and Development Program of China(No.2016YFC0901502 to Kai-Feng Xu,No.2016YFC0905100 to Xue Zhang,No.2017YFC1001201 to Yaping Liu);the National Natural Science Foundation of China(NSFC)(No.81788101 to Xue Zhang,No.31271345 to Yaping Liu);the CAMS Initiative for Medical Sciences(CIFMS)(Nos.2021-1-I2M-018 and 2016-I2M-1-002 to Xue Zhang and Yaping Liu,Nos.2020-I2M-C&T-B-002 and 2018-I2M-1-003 to Xinlun Tian).
Primary ciliary dyskinesia(PCD)is a highly heterogeneous recessive inherited disorder.FAP54,the homolog of CFAP54 in Chlamydomonas reinhardtii,was previously demonstrated as the C1d projection of the central microtubu...
关键词：primary ciliary dyskinesia CFAP54 CILIA 
Bioinspired magnetic cilia:from materials to applications
《Microsystems & Nanoengineering》2023年第6期107-128,共22页Seongjin Park Geonjun Choi Minsu Kang Woochan Kim Jangho Kim Hoon Eui Jeong 
supported by the National Research Foundation of Korea(NRF)(2021R1A2C3006297,2021R1A4A3025206);the Technology Innovation Program(00144157)funded by the Ministry of Trade,Industry&Energy(MOTIE,Korea).
Microscale and nanoscale cilia are ubiquitous in natural systems where they serve diverse biological functions.Bioinspired artificial magnetic cilia have emerged as a highly promising technology with vast potential ap...
关键词：MAGNETIC OVERCOME PRECISE 
Dynein axonemal heavy chain 10 deficiency causes primary ciliary dyskinesia in humans and mice被引量：1
《Frontiers of Medicine》2023年第5期957-971,共15页Rongchun Wang Danhui Yang Chaofeng Tu Cheng Lei Shuizi Ding Ting Guo Lin Wang Ying Liu Chenyang Lu Binyi Yang Shi Ouyang Ke Gong Zhiping Tan Yun Deng Yueqiu Tan Jie Qing Hong Luo 
supported by the National Natural Science Foundation of China (Nos.82070003,82100057,81900002,82101961,31970504,and 31772548);Natural Science Foundation of Hunan Province,China (Nos.2020JJ5805 and 2021JJ30943);Xiangya Clinical Big Data System Construction Project in Pulmonary Inflammatory Disease of Central South University;the National Key Clinical Specialty Construction Projects of China。
Primary ciliary dyskinesia(PCD)is a congenital,motile ciliopathy with pleiotropic symptoms.Although nearly 50 causative genes have been identified,they only account for approximately 70%of definitive PCD cases.Dynein ...
关键词：DNAH10 MICE motile cilia mutation primary ciliary dyskinesia 
Artificial cilia for soft and stable surface covalent immobilization of bone morphogenetic protein-2被引量：1
《Bioactive Materials》2023年第6期551-562,共12页Qi Gan Lina Chen Ho-Pan Bei Sze-Wing Ng Han Guo Guoqiang Liu Hao Pan Changsheng Liu Xin Zhao Zijian Zheng 
financial support from RGC Senior Research Fellow Scheme(SRFS2122-5S04),Research Grants Council of Hong Kong;Collaborative Research Fund(C5044-21GF)from the Research Grants Council of Hong Kong and National Excellent Young Scientists Fund(Hong Kong and Macao,82122002),National Natural Science Foundation of China;support from National Natural Science Foundation of China(No.32071337);Shanghai Pujiang Program(20PJ1402600).
Preservation of growth factor sensitivity and bioactivity(e.g.,bone morphogenetic protein-2(BMP-2))post-immobilization to tissue engineering scaffolds remains a great challenge.Here,we develop a stable and soft surfac...
关键词：Polymer brush Poly(glycidyl methacrylate) Surface modification Protein immobilization Bioactivity 
Ccdc57 is required for straightening the body axis by regulating ciliary motility in the brain ventricle of zebrafish被引量：3
《Journal of Genetics and Genomics》2023年第4期253-263,共11页Lu Li Juan Li Yuan Ou Jiaxin Wu Huilin Li Xin Wang Liying Tang Xiangyan Dai Conghui Yang Zehong Wei Zhan Yin Yuqin Shu 
supported by the National Key Research and Development Program,China(2018YFD0900406);the National Natural Science Foundation,China(31802291);the Natural Science Foundation of Hunan Province(2021JJ40342)。
Recently,cilia defects have been proposed to contribute to scoliosis.Here,we demonstrate that coiled-coil domain-containing 57(Ccdc57)plays an essential role in straightening the body axis of zebrafish by regulating c...
关键词：Scoliosis CSF ccdc57 CILIA EPINEPHRINE UROTENSIN 
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