UROTENSIN

作品数：42被引量：70H指数：5
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相关领域：医药卫生更多>>
相关作者：刘亮明梁冬雨于芳苹李晨娟叶长根更多>>
相关机构：山西医科大学上海交通大学附属第一人民医院山西医科大学第一医院北京大学更多>>
相关期刊：《中国优生与遗传杂志》《医学分子生物学杂志》《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划山西省科技攻关计划项目上海市自然科学基金更多>>
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Urotensin-I suppresses the hypothalamo-hypophyseal-ovarian axis in the Mozambique tilapia,Oreochromis mossambicus
《Aquaculture and Fisheries》2024年第3期339-346,共8页Jyoti A.Kumbar C.B.Ganesh 
supported by a grant from Science and Engineering Research Board-Department of Science and Technology(No.EEQ/2017/414) and New Delhi,Government of India.
Urotensin-I(UI)is a peptide belonging to the corticotropin-releasing hormone family,produced in the urophysis of teleosts.This investigation was undertaken to examine the effect of UI on the hypothalamo-hypophyseal-ov...
关键词：Urotensin-I CRH family Gonadotropin-releasing hormone Luteinizing hormone OVARY Oreochromis mossambicus 
Ccdc57 is required for straightening the body axis by regulating ciliary motility in the brain ventricle of zebrafish被引量：3
《Journal of Genetics and Genomics》2023年第4期253-263,共11页Lu Li Juan Li Yuan Ou Jiaxin Wu Huilin Li Xin Wang Liying Tang Xiangyan Dai Conghui Yang Zehong Wei Zhan Yin Yuqin Shu 
supported by the National Key Research and Development Program,China(2018YFD0900406);the National Natural Science Foundation,China(31802291);the Natural Science Foundation of Hunan Province(2021JJ40342)。
Recently,cilia defects have been proposed to contribute to scoliosis.Here,we demonstrate that coiled-coil domain-containing 57(Ccdc57)plays an essential role in straightening the body axis of zebrafish by regulating c...
关键词：Scoliosis CSF ccdc57 CILIA EPINEPHRINE UROTENSIN 
Globular adiponectin-mediated vascular remodeling by affecting the secretion of adventitial-derived tumor necrosis factor-αinduced by urotensinⅡ
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2022年第12期1014-1027,共14页Jun LI Limin LUO Yonggang ZHANG Xiao DONG Shuyi DANG Xiaogang GUO Wenhui DING 
supported by the the National Natural Science Foundation of China(No.82003372);the Natural Science Foundation of Hubei Province(Nos.2018CFB747 and 2018CFB537);the Educational Commission of Hubei Province(Nos.B2017112 and B20181130),China.
Objectives:In this study,we explored how adiponectin mediated urotensinⅡ(UⅡ)-induced tumor necrosis factor-α(TNF-α)andα-smooth muscle actin(α-SMA)expression and ensuing intracellular signaling pathways in advent...
关键词：Urotensin II ADIPONECTIN Signal transduction Adventitial fibroblast RNA interference(RNAi) Adiponectin-knockout(APN-KO) 
Urotensin Ⅱ level is elevated in inflammatory bowel disease patients
《World Journal of Gastroenterology》2022年第35期5230-5232,共3页Yan Zhang Guo-Xun Chen 
It was reported that the urotensin Ⅱ(U-Ⅱ) level in inflammatory bowel disease(IBD) patients are significantly higher than in controls. To provide future guidance for the management of cardiovascular risk factors in ...
关键词：Inflammatory bowel disease UrotensinⅡ Inflammatory factors High sensitivity C reactive peptide 
Urotensin Ⅱ and urantide exert opposite effects on the cellular components of atherosclerotic plaque in hypercholesterolemic rabbits被引量：2
《Acta Pharmacologica Sinica》2020年第4期546-553,共8页Qing-qing Yu Da-xin Cheng Li-ran Xu Yan-kui Li Xiao-ya Zheng Yi Liu Ya-feng Li Hao-le Liu Liang Bai Rong Wang Jiang-lin Fan En-qi Liu Si-hai Zhao 
supported by grants from the National Natural Science Foundation of China(81370379 and 30900526 to SHZ);the Natural Science Foundation of Shaanxi Province(2017BSHQYXMZZ18 to YFL,2012KJXX-07,2014JQ4137 to SHZ and 2014FWPT07 to EQL);the Fundamental Research Fund for the Central Universities(SHZ).
Increasing levels of plasma urotensin II(UII)are positively associated with atherosclerosis.In this study we investigated the role of macrophage-secreted UII in atherosclerosis progression,and evaluated the therapeuti...
关键词：UROTENSIN II URANTIDE atherosclerosis PLAQUE MACROPHAGE 
Urantide抑制动脉粥样硬化大鼠心脏中Ⅲ型胶原表达被引量：1
《基础医学与临床》2019年第8期1193-1195,共3页曹宇光 王途 孙晓旭 孙美莎 杨舒涵 王博 赵娟 
承德医学院河北省大学生创新创业训练计划项目(2018021);河北省教育厅优秀青年基金项目(YQ2013005);河北省青年拔尖人才项目(冀组字[2016]9号);河北省高校重点学科建设项目(冀教高【2013】4号病理学与病理生理学)
尾加压素Ⅱ(urotensinⅡ,UⅡ)及其受体构成的UⅡ/UT受体系统可促进动脉粥样硬化(atherosclerosis,AS)等心血管疾病的发生发展[1]。Urantide是一种UⅡ/UT受体系统的阻断剂[2]。Urantide对由AS引起缺血缺氧所造成的心肌纤维化是否有效,尚...
关键词：URANTIDE 动脉粥样硬化 大鼠心脏 胶原表达 urotensinⅡ Ⅲ型 受体系统 尾加压素Ⅱ 
Urotensin Ⅱ receptor antagonist reduces hepatic resistance and portal pressure through enhanced eNOS-dependent HSC vasodilatation in CCI4-induced cirrhotic rats被引量：1
《Frontiers of Medicine》2019年第3期398-408,共11页Ruoxi Zhang Jing Chen Diangang Liu Yu Wang 
the National Natural Science Foundation of China (No.81170408 to Diangang Liu);the Wang Baoen Liver Fibrosis Research Foundation of the China Hepatitis Prevention Foundation (No.20120124 to Diangang Liu);the China Postdoctoral Science Foundation (No.2012M510094 to Diangang Liu).
Increased serum urotensin Ⅱ(UⅡ) levels in human cirrhotic populations have been recently shown,but the long-term effects of UⅡ receptor antagonist on the cirrhosis have not been investigated.To investigate the ther...
关键词：PORTAL hypertension cirriiosis UROTENSIN Ⅱ palosuran HEPATIC stellate cell 
UⅡ/UT系统对LPS刺激枯否细胞TRAF6和ROS表达以及自噬与凋亡的影响被引量：1
《医学分子生物学杂志》2018年第4期211-216,共6页钟欢 何玉 杨雪 施青青 徐国荣 谢平 柴莉丽 刘亮明 
国家自然科学基金（No.81770612,81070357,30660066）,上海市松江区科学技术攻关项目（No.16SJGC21）,江苏省研究生教育教学改革课题（No.JX22013457）
目的在分析urotensin（UⅡ）／urotensin Ⅱ receptor（uT）系统对LPS（lipopolysaccharide）刺激枯否细胞（Kupffcr cell，KC）肿瘤坏死因子受体相关因子6（TNF receptor．associated factor6，TRAF6）表达和活性氧簇（reactive oxygen...
关键词：urotensinⅡ 枯否细胞 脂多糖 肿瘤坏死因子受体相关因子6 活性氧簇 自噬 凋亡 
人urotensin Ⅱ对大鼠心肌细胞缺氧-再给氧损伤的保护作用及机制被引量：2
《中国临床药理学与治疗学》2016年第12期1341-1346,共6页王荣俊 丁波 文继月 陈志武 
国家自然科学基金项目(81374002)
目的:研究人urotensinⅡ(human urotensin II,h UII)对大鼠心肌细胞缺氧-再给氧损伤的作用及机制。方法:将培养的新生大鼠心肌细胞缺氧3 h后再给氧3 h造成细胞缺氧再给氧损伤(A/R)模型,用台盼蓝染色和MTT染色法分别检测细胞存活率和细...
关键词：urotensinⅡ 心肌细胞 缺氧再给氧损伤 细胞内游离钙离子 一氧化氮 
Urotensin Ⅱ-induced insulin resistance is mediated by NADPH oxidase-derived reactive oxygen species in Hep G2 cells被引量：5
《World Journal of Gastroenterology》2016年第25期5769-5779,共11页Ying-Ying Li Zheng-Ming Shi Xiao-Yong Yu Ping Feng Xue-Jiang Wang 
Supported by National Natural Science Foundation of China,No.81272757;the Project of Construction of Innovative Teams and Teacher Career Development for Universities and Colleges under Beijing Municipality,No.IDHT20150502
AIM: To investigated the effects of urotensin Ⅱ(UII) on hepatic insulin resistance in Hep G2 cells and the potential mechanisms involved.METHODS: Human hepatoma Hep G2 cells were cultured with or without exogenous UI...
关键词：UROTENSIN Ⅱ Insulin resistance NADPH OXIDASE Reactive oxygen species HEPG 2 CELLS 
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