supported by the National Key Research and Development Project(China)(No.2018YFE0195100);the National Natural Science Foundation of China(No.82020108030);the Key Scientific Research Projects in Colleges and Universities of Henan Province,China(No.23A350007).
SLC7A11,as the core component of system xc,protects cancer cells from oxidative-stress-induced cell death like ferroptosis by mediating cystine uptake.Recent studies revealed that SLC7A11 is widely overexpressed in va...
supported by grants to S.C.L.from the Swee Liew-Wadsworth Endowment fund,National University of Singapore(NUS),Ministry of Education(MOE-T2EP30220-0014),Singapore;the National Research Foundation(NRF-ISF003-3221),Singapore;grants to H.M.S.from University of Macao(CPG2023-0032FHS and UM-MYRG2020-00022-FHS);Macao Science and Technology Development Fund(FDCT0078/2020/A2,FDCT0031/2021/A1,FDCT0081/2022/AMJ,and FDCT 0004/2021/AKP);supported by the NUS Graduate School Research Scholarships.
Glucose-6-phosphate dehydrogenase(G6PD)is the rate-limiting enzyme in the pentose phosphate pathway(PPP)in glycolysis.Glucose metabolism is closely implicated in the regulation of mitophagy,a selective form of autopha...
supported by the National Key Research and Development Program of China(Grant 2019YFA0904800);the National Natural Science Foundation of China(Grant U23A20530,82173746 and 82104066);the Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism(Shanghai Municipal Education Commission).
Identification of compounds to modulate NADPH metabolism is crucial for understanding complex diseases and developing effective therapies.However,the complex nature of NADPH metabolism poses challenges in achieving th...