SIGNALLING

作品数：83被引量：405H指数：8
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Ginsenoside Rg1 mitigates cerebral ischaemia/reperfusion injury in mice by inhibiting autophagy through activation of mTOR signalling
《Acta Pharmacologica Sinica》2024年第12期2474-2486,共13页Zhi-chao Xi Han-gui Ren Lin Ai Yuan Wang Meng-fan Liu Yu-fei Qiu Ji-ling Feng Wang Fu Qian-qian Bi Feng Wang Hong-xi Xu 
supported by Natural Science Foundation of Shanghai(23ZR1448700);Shanghai Science and Technology Commission:Scientific and Technological Innovation Action Plan Medical Innovation Research Special Project(23Y11906400);Outstanding Leaders Training Program of Pudong Health Bureau of Shanghai(PWR12020-03);The Shanghai University of Traditional Chinese Medicine Budget Project(23KFL041).
Reperfusion injury,which is distinct from ischaemic injury,occurs when blood flow is restored in previously ischaemic brain tissue,further compromising neurons and other cells and worsening the injury.There is current...
关键词：ischaemic stroke cerebral ischaemia/reperfusion injury ginsenoside Rg1 AUTOPHAGY lysosome function MTOR 
Human umbilical cord mesenchymal stem cells attenuate diabetic nephropathy through the IGF1R-CHK2-p53 signalling axis in male rats with type 2 diabetes mellitus
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2024年第7期568-580,共13页Hao ZHANG Xinshu WANG Bo HU Peicheng LI Yierfan ABUDUAINI Hongmei ZHAO Ayinaer JIEENSIHAN Xishuang CHEN Shiyu WANG Nuojin GUO Jian YUAN Yunhui LI Lei LI Yuntong YANG Zhongmin LIU Zhaosheng TANG Hua WANG 
supported by the Peak Disciplines(Type IV)of Institutions of Higher Learning in Shanghai,the Discipline Leader Program of Pudong New District Health and Family Planning Commission(No.PWRd2018-02);the Natural Science Foundation of Jiangxi Province(Nos.20181ACB20021 and 20181BAB205044),China.
diabetes mellitus(DM)is a disease syndrome characterized by chronic hyperglycaemia.A long-term high-glucose environment leads to reactive oxygen species(ROS)production and nuclear DNA damage.human umbilical cord mesen...
关键词：Insulin-like growth factor 1 receptor(IGF1R) Checkpoint kinase 2(CHK2) Protein 53(p53) Diabetes mellitus Human umbilical cord mesenchymal stem cell(HUcMSC) DNA damage repair 
Inhibition of IL-11 signalling extends mammalian healthspan and lifespan
《四川生理科学杂志》2024年第7期1635-1635,共1页Anissa A Widjaja 
For healthspan and lifespan,ERK,AMPK and mTORC1 represent critical pathways and inflammation is a centrally important hallmark1-7.Here we examined whether IL-11,a pro-inflammatory cytokine of the IL-6 family,has a neg...
关键词：INFLAMMATION mTORC1 life 
Blockade of TNF-α/TNFR2 signalling suppresses colorectal cancer and enhances the efficacy of anti-PD1 immunotherapy by decreasing CCR8+T regulatory cells
《Journal of Molecular Cell Biology》2024年第6期43-58,共16页Yixian Guo Feng Xie Xu Liu Shouyu Ke Jieqiong Chen Yi Zhao Ning Li Zeyu Wang Gang Yi Yanying Shen Dan Li Chunchao Zhu Zizhen Zhang Gang Zhao Hong Lu Bin Li Wenyi Zhao 
National Natural Science Foundation of China(31872740,31961133011,32070878,and 81830051);Innovative Research Team of High-level Local Universities in Shanghai(SHSMU-ZDCX20210601).
The enrichment of regulatory T cells(Tregs)in the tumour microenvironment(TME)has been recognized as one of the major factors in the initiation and development of resistance to immune checkpoint inhibitors.C–C motif ...
关键词：TNFR2 CCR8 regulatory T cells colorectal cancer 
Traditional Chinese medicine Pien-Tze-Huang ameliorates LPS-induced sepsis through bile acid-mediated activation of TGR5-STAT3-A20 signalling
《Journal of Pharmaceutical Analysis》2024年第4期601-614,共14页Bei Li Yong Zhang Xinyuan Liu Ziyang Zhang Shuqing Zhuang Xiaoli Zhong Wenbo Chen Yilin Hong Pingli Mo Shuhai Lin Shicong Wang Chundong Yu 
supported by research funds from Zhangzhou Pien Tze Huang Pharmaceutical Co.Ltd(Grant Nos.:437b8f31,d6092dae,YHT-19064 to Chundong Yu);the National Natural Science Foundation of China(Grant Nos.:81970485,82173086 to Chundong Yu);the Natural Science Foundation of Fujian Province(Grant No.:2023J01249 to Shicong Wang).
Pien Tze Huang(PZH),a class-1 nationally protected traditional Chinese medicine(TCM),has been used to treat liver diseases such as hepatitis;however,the effect of PZH on the progression of sepsis is unknown.Here,we re...
关键词：Pien Tze Huang Bile acids SEPSIS Inflammation TGR5 STAT3-A20 signalling 
Genome editing of PAR2 through targeted delivery of CRISPR-Cas9 system for alleviating acute lung inflammation via ERK/NLRP3/IL-1β and NO/iNOS signalling
《Acta Pharmaceutica Sinica B》2024年第3期1441-1456,共16页Xin Zhuo Yue Wu Xiujuan Fu Jianbin Li Yuxin Xiang Xiaoyu Liang Canquan Mao Yuhong Jiang 
supported by the National Natural Science Foundation of China(Nos.82003784 and 81872789);the Fundamental Research Funds for the Central Universities(No.2682022ZTPY037,China);Large Instruments Open Foundation of Southwest Jiaotong University(No.2022SRII-046,China)。
Excessive and uncontrollable inflammatory responses in alveoli can dramatically exacerbate pulmonary disease progressions through vigorous cytokine releases,immune cell infiltration and protease-driven tissue damages....
关键词：Protease-activated receptor 2(PAR2) CRISPR-Cas9 Gene editing Inflammation Acute lung inflammation NLRP3 Nanoparticles Drug delivery 
A metabolic signalling role for arginine in liver cancer
《Life Metabolism》2024年第1期1-3,共3页David Sokolov Lucas B.Sullivan 
support from the National Institute of General Medical Sciences,R35GM147118 to LS and PHS NRSA T32GM007270 to DS.
In addition to their canonical roles in biosynthetic pathways,metabolites can be active participants in oncogenic signal-ling,but our understanding of these signalling mechanisms is incomplete.In a recent article publ...
关键词：INCOMPLETE CANCER 
LncRNA NKILA inhibits HBV replication by repressing NF-κB signalling activation
《Virologica Sinica》2024年第1期44-55,共12页Xi Zhang Yuanyuan Li Chen Huan Yubao Hou Rujia Liu Hongyun Shi Peng Zhang Baisong Zheng Yingchao Wang Hong Wang Wenyan Zhang 
supported in part by funding from the National Key R&D Program of China(2021YFC2301900,2021YFC2301903,and 2021YFC2301904);National Natural Science Foundation of China(81672004 and 81930062 to WZ;81801993 to HW);Science and Technology Department of Jilin Province(20190101003JH,20190201272JC,20200201331JC,and 20200201422JC);the Key Laboratory of Molecular Virology,Jilin Province(20102209);supported by Fundamental Research Funds for Central Universities.
Hepatitis B virus(HBV)infection results in liver cirrhosis and hepatocellular carcinoma(HCC).HBx/nuclear factor(NF)-κB pathway plays a role in HBV replication.However,whether NF-κB-interacting long noncoding RNA(NKI...
关键词：LncRNA NF-κB-interacting longnoncoding RNA(NKILA) NF-ĸB signalling ChronichepatitisBvirus(HBV) Viral replication HBX 
Enhanced liver X receptor signalling reduces brain injury and promotes tissue regeneration following experimental intracerebral haemorrhage:roles of microglia/macrophages
《Stroke & Vascular Neurology》2023年第6期486-502,I0073-I0080,共25页Ruiyi Zhang Yifei Dong Yang Liu Dorsa Moezzi Samira Ghorbani Reza Mirzaei Brian M Lozinski Jeff F Dunn V Wee Yong Mengzhou Xue 
the Canadian Institutes of Health Research(Foundation grant 1049959)(VWY);from the National Key Research and Development Program of China(grant no:2018YFC1312200);the National Natural Science Foundation of China(grants no:82071331,81870942 and 81520108011)(MX).RZ is supported by a PhD studentship from the China Scholarship Council.
background Inflammation-exacerbated secondary brain injury and limited tissue regeneration are barriers to favourable prognosis after intracerebral haemorrhage(ICH).As a regulator of inflammation and lipid metabolism,...
关键词：METABOLISM injury depletion 
Phosphoinositides in plant-pathogen interaction:trends and perspectives
《Stress Biology》2023年第1期52-68,共17页Fauzia Zarreen Kamal Kumar Supriya Chakraborty 
Financial support from DST FIST Ⅱ and DBT BUILDER to SC(SC/DBT-BUILDER/2022)is gratefully acknowledged;SERB and CSIR for providing National Post-doctoral fellowship and Ph.D.scholarship,respectively.
Phosphoinositides are important regulatory membrane lipids,with a role in plant development and cellular function.Emerging evidence indicates that phosphoinositides play crucial roles in plant defence and are also uti...
关键词：Plant virus KINASES PHOSPHOINOSITIDES PHOSPHATIDYLINOSITOL PLANT-PATHOGEN SIGNALLING 
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