PHOSPHATIDYLINOSITOL

作品数：99被引量：387H指数：11
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Endosomal catabolism of phosphatidylinositol 4,5-bisphosphate is fundamental in building resilience against pathogens
《Protein & Cell》2025年第3期161-187,共27页Chao Yang Longfeng Yao Dan Chen Changling Chen Wenbo Li Hua Tong Zihang Cheng Yanling Yan Long Lin Jing Zhang Anbing Shi 
The National Key R&D Program of China(2021YFA1300302);the National Natural Science Foundation of China(32320103007,32130027);the National Science Fund for Distinguished Young Scholars(31825017);the Major Research Plan of the Natural Science Foundation of China(92154001)to A.Shi.
Endosomes are characterized by the presence of various phosphoinositides that are essential for defining the membrane properties.However,the interplay between endosomal phosphoinositides metabolism and innate immunity...
关键词：C.elegans RAB-10/Rab10 UNC-16/JIP3 sorting endosome EGL-8/PLC-β NHR-25/NR5A1/2 PI(4 5)P2 
Heme oxygenase 1-mediated ferroptosis in Kupffer cells initiates liver injury during heat stroke
《Acta Pharmaceutica Sinica B》2024年第9期3983-4000,共18页Ru Li Riqing Wei Chenxin Liu Keying Zhang Sixiao He Zhifeng Liu Junhao Huang Youyong Tang Qiyuan An Ligen Lin Lishe Gan Liying Zhao Xiaoming Zou Fudi Wang Yuan Ping Qiang Ma 
the following funding sources:the National Natural Science Foundation of China(82072100 to Qiang Ma and 82172814 to Liying Zhao);the Natural Science Foundation of Shenzhen(JCYJ20210324120212033,China);Guangdong Provincial Key Laboratory of Immune Regulation and Immunotherapy,School of Laboratory Medicine and Biotechnology,Southern Medical University(2022B1212010009,China).
With the escalating prevalence of global heat waves,heat stroke has become a prominent health concern,leading to substantial liver damage.Unlike other forms of liver injury,heat strokeinduced damage is characterized b...
关键词：Heat stroke Liver injury Kupffer cells Ferroptosis Heme oxygenase 1 Phosphatidylinositol 4-kinase beta NLRP3 Early growth response factor 1 
Identification of collagen subtypes of gastric cancer for distinguishing patient prognosis and therapeutic response
《Cancer Innovation》2024年第4期87-102,共16页Di Wang Jing Zhang Jianchao Wang Zhonglin Cai Shanfeng Jin Gang Chen 
Science and Technology Program of Fujian Province of China,Grant/Award Number:2019YZ016006;Scientific Research Foundation of Fujian Cancer Hospital,Grant/Award Number:2022YNG08。
Background:Gastric cancer is a highly heterogeneous disease,presenting a major obstacle to personalized treatment.Effective markers of the immune checkpoint blockade response are needed for precise patient classificat...
关键词：BIOMARKER cancer classification COLLAGEN gastric cancer phosphatidylinositol 3‐kinase 
Tongxinluo Activates PI3K/AKT Signaling Pathway to Inhibit Endothelial Mesenchymal Transition and Attenuate Myocardial Fibrosis after Ischemia-Reperfusion in Mice被引量：3
《Chinese Journal of Integrative Medicine》2024年第7期608-615,共8页WEI Ya-ru HOU Yun-long YIN Yu-jie LI Zhen LIU Yi HAN Ning-xin WANG Zi-xuan LIU Lu WANG Xiao-qi HAO Yuan-jie MA Kun GU Jiao-jiao JIA Zhen-hua 
Supported by the National Natural Science Foundation of China(No.81973692);Traditional Chinese Medicine Innovation Project of Hebei Province(No.223777120D);High-Level Talent Funding Program of Hebei(No.E2020100001)。
Objective To investigate the potential role of Tongxinluo(TXL)in attenuating myocardial fibrosis after myocardial ischemia-reperfusion injury(MIRI)in mice.Methods A MIRI mouse model was established by left anterior de...
关键词：myocardial fibrosis endothelial mesenchymal transition myocardial ischemia-reperfusion injury phosphatidylinositol-3-kinase/protein kinase B(PI3K/AKT)pathway 
Electroacupuncture Promotes Functional Recovery after Facial Nerve Injury in Rats by Regulating Autophagy via GDNF and PI3K/m TOR Signaling Pathway被引量：1
《Chinese Journal of Integrative Medicine》2024年第3期251-259,共9页YAO Jun-peng FENG Xiu-mei WANG Lu LI Yan-qiu ZHU Zi-yue YAN Xiang-yun YANG Yu-qing LI Ying ZHANG Wei 
Supported by the National Natural Science Foundation of China (No.81603706)。
Objective:To explore the mechanism of electroacupuncture(EA) in promoting recovery of the facial function with the involvement of autophagy,glial cell line-derived neurotrophic factor(GDNF),and phosphatidylinositol-3-...
关键词：ELECTROACUPUNCTURE facial nerve injury AUTOPHAGY glial cell line-derived neurotrophic factor phosphatidylinositol-3-kinase/mammalian target of rapamycin Chinese medicine 
Clean-DM1, a Korean Polyherbal Formula, Improves High Fat Diet-Induced Diabetic Symptoms in Mice by Regulating IRS/PI3K/AKT and AMPK Expressionsin Pancreas and Liver Tissues
《Chinese Journal of Integrative Medicine》2024年第2期125-134,共10页Piao Wang Yi Liu Seok Yong Kang Chenzi Lyu Xiang Han Tianjun Ho Kyung Jae Lee Xianglong Meng Yong-Ki Park Hyo Won Jung 
Supported by Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI),the Ministry of Health&Welfare,Republic of Korea (No. HF20C0121);Shanxi Key Laboratory of Tradition Herbal Medicines Processing (No. 20210901);the Innovation Team of Shanxi University of Chinese Medicine (No. 2022TD1014)
Objective:To investigate the effects of Clean-DM1(C-DM1),a polyherbal formulation of Radix Scrophulariae,Radix Astragali,Rhizoma Atractylodis,and Radix Salviae Miltiorrhizae,on high-fat diet(HFD)-induced diabetes mice...
关键词：high-fat diet type 2 diabetes mellitus herbal formulation insulin receptor substrate/phosphatidylinositol 3 kinase/protein kinase B adenosine 5'-monophosphate-activated protein kinase network pharmacology high performance liquid chromatography-mass spectrometry analysis 
Bornyl acetate extracted from Sharen(Fructus Amomi)inhibits proliferation,invasion and induces apoptosis by suppressing phosphatidylinositol-3-kinase/protein kinase B signaling in colorectal cancer被引量：2
《Journal of Traditional Chinese Medicine》2023年第6期1081-1091,共11页LI Xiaohua DUAN Zhihang YUE Jianjun ZHANG Yongyu LI Yihang LIU Shifang NIE Qu YANG Depo ZHANG Lixia 
National Key R&D Program of China:Underground Ecological Planting Technology and Base Establishment of Sharen (Fructus Amomi) in the forest (2017YFC1701102);West Yunnan University of Applied Sciences University-level Engineering Research Center projects:Characteristic Dai-Medicine Resource ERC of West Yunnan University of Apllied Science (2022KYPT0004);National Natural Science Foundation of China:Study on the symbiotic system of Sharen (Fructus Amomi);weevil pollination and its "push-pull" pollination mechanism (82260736);Yunnan key labotatory of southern medicine utilization:Major Science and Technology Special Plan of Yunnan Province (202102AA100020);Scientific and Technological Talents and Platform Plan of Yunnan Province (202105AG070011)
OBJECTIVE:To investigate the antitumor effects of bornyl acetate(BA)isolated from Sharen(Fructus Amomi)in colorectal cancer(CRC)and the underlying mechanisms.METHODS:SW480 and HT29 cells were treated with increasing d...
关键词：bornyl acetate colorectal neoplasms phosphatidylinositol 3-kinase protein kinases B signal transduction 
Phosphoinositides in plant-pathogen interaction:trends and perspectives
《Stress Biology》2023年第1期52-68,共17页Fauzia Zarreen Kamal Kumar Supriya Chakraborty 
Financial support from DST FIST Ⅱ and DBT BUILDER to SC(SC/DBT-BUILDER/2022)is gratefully acknowledged;SERB and CSIR for providing National Post-doctoral fellowship and Ph.D.scholarship,respectively.
Phosphoinositides are important regulatory membrane lipids,with a role in plant development and cellular function.Emerging evidence indicates that phosphoinositides play crucial roles in plant defence and are also uti...
关键词：Plant virus KINASES PHOSPHOINOSITIDES PHOSPHATIDYLINOSITOL PLANT-PATHOGEN SIGNALLING 
Osteopontin promotes gastric cancer progression via phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin signaling pathway
《World Journal of Gastrointestinal Oncology》2023年第9期1544-1555,共12页Yue-Chao Qin Xin Yan Xiao-Lin Yuan Wei-Wei Yu Fan-Jie Qu 
BACKGROUND Gastric cancer(GC)is one of the most common malignant tumors.Osteopontin(OPN)is thought to be closely related to the occurrence,metastasis and prognosis of many types of tumors.AIM To investigate the effect...
关键词：OSTEOPONTIN Proliferation INVASION Migration Gastric cancer Phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin signaling pathway 
The phosphatidylinositol(4,5)-bisphosphate-Rab35 axis regulates migrasome formation被引量：4
《Cell Research》2023年第8期617-627,共11页Tianlun Ding Jinyao Ji Weiying Zhang Yuheng Liu Boqi Liu Yiyang Han Chunlai Chen Li Yu 
the National Natural Science Foundation of China(32030023 and 92054301);Beijing Municipal Science&Technology Commission,Administrative Commission of Zhongguancun Science Park(Z221100003422012);Tsinghua University Initiative Scientific Research Program(20221080007)。
Migrasomes are recently discovered organelles,which are formed on the ends or branch points of retraction fibers at the trailing edge of migrating cells.Previously,we showed that recruitment of integrins to the site o...
关键词：Rab3 TRAIL SOME 
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