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Role of P-Gp in Treatment of Cancer: 《Journal of Cancer Therapy》2025年第1期1-17,共17页Venkata Sai Nithin Reddy Yendapalli Kelley Williams Terry Oroszi; P-glycoprotein (P-gp), a member of the ATP-binding cassette (ABC) family of transporters, plays a crucial role in the development of multi-drug resistance (MDR) in cancer treatment. P-gp actively pumps chemotherapeuti...; 关键词：P-Glycoprotein (P-Gp) Multi-Drug Resistance (MDR) Cancer Treatment ABC Transporters Chemotherapy Resistance P-Gp Inhibitors Drug Efflux Mechanisms Fourth-Generation Inhibitors

Association of ABCB1 gene polymorphisms rs1128503, rs2032582, rs4148738 with anemia in patients receiving dabigatran after total knee arthroplasty: 《Chinese Journal of Traumatology》2024年第1期27-33,共7页Alina Kasimova Dmitry Labutin Anton Gvozdetsky Svetlana Bozhkova; supported by the Vreden National Medical Research Center of Traumatology and Orthopaedics。; Purpose:Dabigatran is usually prescribed in recommended doses without monitoring of the blood coagulation for the prevention of venous thromboembolism after joint arthroplasty.ABCB1 is a key gene in the metabolism of ...; 关键词：THROMBOPROPHYLAXIS P-GLYCOPROTEIN DABIGATRAN ANEMIA SNPs

The multidrug resistance transporter P-glycoprotein confers resistance to ferroptosis inducers: 《Cancer Drug Resistance》2023年第3期468-480,共13页William J.E.Frye Lyn M.Huff JoséM.González Dalmasy Paula Salazar Rachel M.Carter Ryan T.Gensler Dominic Esposito Robert W.Robey Suresh V.Ambudkar Michael M.Gottesman; This research was funded by the Intramural Research Program of the National Institutes of Health,the National Cancer Institute.; Aim:Ferroptosis is a non-apoptotic form of cell death caused by lethal lipid peroxidation.Several small molecule ferroptosis inducers(FINs)have been reported,yet little information is available regarding their interac...; 关键词：Ferroptosis drug resistance P-GLYCOPROTEIN ABCG2

Effect of Cyclooxygenase Inhibition on P-Glycoprotein Expression and Phenytoin Level in Brain Tissue of Pilocarpine Induced Epilepsy in Rats: 《Journal of Biosciences and Medicines》2023年第8期169-191,共23页Reham M. Elsayed Amira S. Mohamed Mona K. Tawfik Magda M. Hagras; Background: Increased brain P-glycoprotein (P-gp) expression may play important role in resistance to antiseizure drugs. The present work aimed to overcome the drug resistance that develop due to overexpression of P-g...; 关键词：P-GLYCOPROTEIN Glutamate PHENYTOIN INDOMETHACIN CELECOXIB EPILEPSY

The relationship among amyloid-βdeposition,sphingomyelin level,and the expression and function of P-glycoprotein in Alzheimer’s disease pathological process被引量：1: 《Neural Regeneration Research》2023年第6期1300-1307,共8页Zi-Kang Xing Li-Sha Du Xin Fang Heng Liang Sheng-Nan Zhang Lei Shi Chun-Xiang Kuang Tian-Xiong Han Qing Yang; supported by the National Key Research and Development Program of China;Nos.2021YFC2 701800 and 2021YFC2 701805 (to QY);Open Research Fund of State Key Laboratory of Genetic Engineering;Fudan University;No.SKLGE-21 19 (to TXH and QY); In Alzheimer’s disease,the transporter P-glycoprotein is responsible for the clearance of amyloid-βin the brain.Amyloid-βcorrelates with the sphingomyelin metabolism,and sphingomyelin participates in the regulation...; 关键词：Alzheimer’s disease amyloid-β APP/PS1 mice CERAMIDE ezrin-radixin-moesin human cerebral microvascular endothelial cells neutral sphingomyelinase 1 P-GLYCOPROTEIN sphingomyelin synthase SPHINGOMYELIN

Mechanisms of imperatorin on regulating Pglycoprotein in blood-brain barrier based on network pharmacology and in vitro experiment: 《中国药理学与毒理学杂志》2023年第S01期17-18,共2页SONG Yizhen YIN Wanxin MA Yicong AN Yufan HUANG Jiaqi YAN Zhongjie WU Xiuwen WANG Yuanyu; Natural Science Foundation of Hebei Province(H2022206456);Natural Sci⁃ence Foundation of Hebei Province(H2021206449);Undergraduate Innovative Experiment Program of Hebei Medical University(USIP2022173);Undergraduate Innovative Experiment Program of Hebei Medical University(USIP2023107)。; OBJECTIVE To explore mecha⁃nisms of imperatorin on regulating P-glycoprotein(P-gp)in blood-brain barrier(BBB)based on net⁃work pharmacology combined with in vitro experi⁃ment.METHODS Drug targets were predicted using ...; 关键词：IMPERATORIN blood-brain barrier P-GLYCOPROTEIN network pharmacology in vitro experiment

P-glycoprotein(ABCB1)-weak dipolar interactions provide the key to understanding allocrite recognition,binding,and transport: 《Cancer Drug Resistance》2023年第1期1-29,共29页Anna Seelig Xiaochun Li-Blatter; Stiftung zur Forderung der biologischen Forschung,Basel,Switzerland.; P-glycoprotein(ABCB1)is the first discovered mammalian member of the large family of ATP binding cassette(ABC)transporters.It facilitates the movement of compounds(called allocrites)across membranes,using the energy o...; 关键词：Catalytic cycle hydrogen bond π-electron donor polyspecificity AMPHIPHILICITY STOICHIOMETRY

Evaluation of P-glycoprotein-targeting circulating microRNAs as peripheral biomarkers for medically intractable epilepsy: 《Acta Epileptologica》2023年第1期14-24,共11页Yangmei Xie Yiye Shao Xue Gong Ming Wang Yinghui Chen; This research was supported by grants from the National Natural Science Foundation of China(81971209)to YC;National Natural Science Foundation of China(82101518)to YS;Shanghai Sailing Program(20YF1439400)to YS.; Background Early diagnosis of medically intractable epilepsy is challenging in clinical work.P-glycoprotein(P-gp)is one of the most important multidrug efux transporters,which has been demonstrated to contribute to th...; 关键词：Intractable epilepsy Drug resistance P-GLYCOPROTEIN Circulating miRNAs BIOMARKER

Salmonella-mediated blood-brain barrier penetration,tumor homing and tumor microenvironment regulation for enhanced chemo/bacterial glioma therapy被引量：7: 《Acta Pharmaceutica Sinica B》2023年第2期819-833,共15页Ze Mi Qing Yao Yan Qi Jinhai Zheng Jiahao Liu Zhenguo Liu Hongpei Tan Xiaoqian Ma Wenhu Zhou Pengfei Rong; supported by the National Natural Science Foundation of China(Nos.U1903125,82071986,82073799,and 81771827);Natural Science Foundation of Hunan province in China(2021JJ20084);the Science and Technology Project of Hunan Province(2021RC4017 and 2021RC3020,China);the Furong Scholars Programme of Hunan Province;the Wisdom Accumulation and Talent Cultivation Project of the Third Xiangya Hospital of Central South University(China)。; Chemotherapy is an important adjuvant treatment of glioma,while the efficacy is far from satisfactory,due not only to the biological barriers of blood-brain barrier(BBB)and blood-tumor barrier(BTB)but also to the intr...; 关键词：GLIOMA Neutrophil hitchhiking Blood-brain barrier Chemo-sensitization Outer membrane vesicles Doxorubicin P-GLYCOPROTEIN Salmonella

Extract of Codiaeum luzonicum Merr. overcomes multidrug resistance in human colon cancer cells by modulating P-glycoprotein被引量：1: 《Asian Pacific Journal of Tropical Biomedicine》2022年第9期400-410,共11页Regina Joyce E.Ferrer Marc Justin C.Ong Sonia D.Jacinto; This work was supported by the University of the Philippines Diliman Office of the Vice Chancellor for Research and Development Outright Grant(grant number 151509 PNSE).; Objective:To investigate anti-multidrug resistance(MDR)activity and safety of the bioactive fraction(CL11)from Codiaeum luzonicum crude leaf extract.Methods:Cytotoxic activity of CL11 against MDR and nonresistant colo...; 关键词：Natural product Leaf extract Codiaeum luzonicum MDR cancer P-gp inhibitor Colorectal cancer

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