云南高校图书馆联盟文献共享服务平台- SPHINGOMYELIN

SPHINGOMYELIN: 作品数：22被引量：33H指数：3; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：蒋宪成董继斌楼滨更多>>; 相关机构：复旦大学纽约州立大学更多>>; 相关期刊：《Science China Chemistry》《World Journal of Gastroenterology》《Advances in Biological Chemistry》《World Journal of Gastrointestinal Pathophysiology》更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金更多>>

Inhibiting ceramide synthase 5 expression in microglia decreases neuroinflammation after spinal cord injury: 《Neural Regeneration Research》2025年第10期2955-2968,共14页Wei Zhang Yubao Lu Ruoqi Shen Yingjie Wu Chenrui Liu Xingxing Fang Liangming Zhang Bin Liu Limin Rong; supported by grants from the National Key Research and Development Program of China,No.2017YFA0105400(to LR);the Key Research and Development Program of Guangdong Province,No.2019B020236002(to LR);the National Natural Science Foundation of China,Nos.81972111(to LZ),81772349(to BL).; Microglia,the resident monocyte of the central nervous system,play a crucial role in the response to spinal cord injury.However,the precise mechanism remains unclear.To investigate the molecular mechanisms by which mi...; 关键词：ceramide synthase 5 gasdermin D MICROGLIA NEUROINFLAMMATION NLRP3 nuclear factor kappa B Pla2g7 PYROPTOSIS sphingomyelin metabolism spinal cord injury

Targeting methyltransferase-like 5-mediated sphingomyelin metabolism:A novel therapeutic approach in gastric cancer: 《World Journal of Gastrointestinal Oncology》2024年第10期4060-4063,共4页Jin-Juan Zhang Chang Yuan Sheng-Chun Dang; Supported by Jiangsu Commission of Health,No.LKZ2023012;Social Development Project of Zhenjiang City,No.SS2023011.; Gastric cancer(GC)is a global health problem and a leading cause of cancerrelated deaths,with its mortality rate ranking third among all cancers.The etiology and progression of GC are characterized by a complex interp...; 关键词：Gastric cancer Methyltransferase-like 5 Sphingomyelin metabolism Biomarkers Chemotherapy response

METTL5 promotes gastric cancer progression via sphingomyelin metabolism被引量：2: 《World Journal of Gastrointestinal Oncology》2024年第5期1925-1946,共22页Ya-Qiong Zhang Jian Li Zhe Qin De-Ming Li Fang-Zhou Ye Song-Hua Bei Xiao-Hong Zhang Li Feng; BACKGROUND The treatment of gastric cancer(GC)has caused an enormous social burden worldwide.Accumulating studies have reported that N6-methyladenosine(m6A)is closely related to tumor progression.METTL5 is a m6A methy...; 关键词：Gastric cancer METTL5 Sphingomyelin metabolism CISPLATIN

A novel mutation in ROR2 led to the loss of function of ROR2 and inhibited the osteogenic differentiation capability of bone marrow mesenchymal stem cells(BMSCs): 《BIOCELL》2023年第7期1561-1569,共9页WENQI CHEN XIAOYANG CHU YANG ZENG YOUSHENG YAN YIPENG WANG DONGLAN SUN DONGLIANG ZHANG JING ZHANG KAI YANG; funded by the Project Funded by China Postdoctoral Science Foundation(No.2022T150445);the Beijing Hospitals Authority Youth Programme(No.QML20211401);the Young Talent Foundation of PLA General Hospital(2019-YQPY-002);Beijing Nova Program(Z201100006820057).; Receptor tyrosine kinase-like orphan receptor 2(ROR2)has a vital role in osteogenesis.However,the mechanism underlying the regulation of ROR2 in osteogenic differentiation is still poorly comprehended.A previous study...; 关键词：Bone marrow mesenchymal stem cells ROR2 WNT5A Osteogenic differentiation SPHINGOMYELIN

The relationship among amyloid-βdeposition,sphingomyelin level,and the expression and function of P-glycoprotein in Alzheimer’s disease pathological process被引量：1: 《Neural Regeneration Research》2023年第6期1300-1307,共8页Zi-Kang Xing Li-Sha Du Xin Fang Heng Liang Sheng-Nan Zhang Lei Shi Chun-Xiang Kuang Tian-Xiong Han Qing Yang; supported by the National Key Research and Development Program of China;Nos.2021YFC2 701800 and 2021YFC2 701805 (to QY);Open Research Fund of State Key Laboratory of Genetic Engineering;Fudan University;No.SKLGE-21 19 (to TXH and QY); In Alzheimer’s disease,the transporter P-glycoprotein is responsible for the clearance of amyloid-βin the brain.Amyloid-βcorrelates with the sphingomyelin metabolism,and sphingomyelin participates in the regulation...; 关键词：Alzheimer’s disease amyloid-β APP/PS1 mice CERAMIDE ezrin-radixin-moesin human cerebral microvascular endothelial cells neutral sphingomyelinase 1 P-GLYCOPROTEIN sphingomyelin synthase SPHINGOMYELIN

Endogenous ceramide phosphoethanolamine modulates circadian rhythm via neural-glial coupling in Drosophila被引量：2: 《National Science Review》2022年第12期98-117,共20页Xiupeng Chen Jie Li Zhongbao Gao Yang Yang Wenqing Kuang Yue Dong Gek Huey Chua Xiahe Huang Binhua Jiang He Tian Yingchun Wang Xun Huang Yan Li Sin Man Lam Guanghou Shui; supported bythe National Natural Science Foundationof China(92057202);the National KeyR&D Program of China(2018YFA0506900,2018YFA0800901 and 2019YFA0802402).; While endogenous lipids are known to exhibit rhythmic oscillations,less is known about how specific lipids modulate circadian behavior.Through a series of loss-of-function and gain-of-function experiments on cer amide...; 关键词：ceramide phosphoethanolamine SPHINGOMYELIN CIRCADIAN LONGEVITY glutamate homeostasis

Nuclear sphingomyelin in neurodegenerative diseases: 《Neural Regeneration Research》2021年第10期2028-2029,共2页Elisabetta Albi Alice V.Alessenko; Introduction:Recently,sphingolipids(SphLs)have become increasingly appreciated as a family of molecules involved in the growth,differentiation,and death of the central nervous system cells.The disequilibrium among the...; 关键词：finally SYSTEM SINE

Ordering effects of cholesterol on sphingomyelin monolayers investigated by high-resolution broadband sum-frequency generation vibrational spectroscopy被引量：1: 《Chinese Chemical Letters》2018年第3期357-360,共4页Yiyi Li Rongjuan Feng Lu Lin Minghua Liu Yuan Guo Zhen Zhang; the National Natural Science Foundation of China(No.21227802);the National Natural Science Foundation of China(Nos. 21503235, 21673251);the ICCAS for Start-up Funding; This report investigated the ordering of the alky chain of sphingomyelin （SMs） monolayers induced by cholesterol at the air/water interface using high-resolution broadband sum frequency generation vibrational spectr...; 关键词：Sphingomyelin Cholesterol Ordering effect Air/liquid interface High-resolution broadband sum frequency generation Vibrational spectroscopy

Alkaline sphingomyelinase(NPP7) in hepatobiliary diseases: A field that needs to be closely studied被引量：5: 《World Journal of Hepatology》2018年第2期246-253,共8页Rui-Dong Duan; supported from grants of Swedish Research Council;Swedish Cancerfonden;Albert P?hlsson Foundation;Crafoord Foundation;foundation of Region Skane University Hospital, Lund, Sweden; Alkaline sphingomyelinase cleaves phosphocholine from sphingomyelin, platelet-activating factor, lysophosphatidylcholine, and less effectively phosphatidyl-choline. The enzyme shares no structure similarities with aci...; 关键词：SPHINGOMYELIN Alkaline sphingomyelinase Nucleotide pyrophosphatase/phosphodiesterase 7 AUTOTAXIN Platelet-activating factor CHOLANGIOCARCINOMA Liver diseases GALLSTONE

Visualization of sphingolipids and phospholipids in the fundic gland mucosa of human stomach using imaging mass spectrometry被引量：1: 《World Journal of Gastrointestinal Pathophysiology》2016年第2期235-241,共7页Nobuya Kurabe Hisaki Igarashi Ippei Ohnishi Shogo Tajima Yusuke Inoue Yoshihiko Takahashi Mitsutoshi Setou Haruhiko Sugimura; AIM:To analyze the lipid distribution in gastric mucosae.METHODS:Imaging mass spectrometry(MS)is a useful tool to survey the distribution of biomolecules in surgical specimens.Here we used the imaging MS apparatus nam...; 关键词：Imaging mass spectrometry i MScope SPHINGOMYELIN PHOSPHATIDYLCHOLINE Gastric MUCOSA

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