IMPERATORIN

作品数：11被引量：47H指数：4
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相关领域：医药卫生更多>>
相关作者：余龙杨鹏远黄兴华芮耀诚蒋建明更多>>
相关机构：第二军医大学复旦大学广州中医药大学浙江大学医学院附属第二医院更多>>
相关期刊：《Chinese Journal of Integrative Medicine》《Chinese Journal of Natural Medicines》《Acta Pharmacologica Sinica》《Pharmacology & Pharmacy》更多>>
相关基金：国家自然科学基金国家科技支撑计划国家重点基础研究发展计划更多>>
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Mechanisms of imperatorin on regulating Pglycoprotein in blood-brain barrier based on network pharmacology and in vitro experiment
《中国药理学与毒理学杂志》2023年第S01期17-18,共2页SONG Yizhen YIN Wanxin MA Yicong AN Yufan HUANG Jiaqi YAN Zhongjie WU Xiuwen WANG Yuanyu 
Natural Science Foundation of Hebei Province(H2022206456);Natural Sci⁃ence Foundation of Hebei Province(H2021206449);Undergraduate Innovative Experiment Program of Hebei Medical University(USIP2022173);Undergraduate Innovative Experiment Program of Hebei Medical University(USIP2023107)。
OBJECTIVE To explore mecha⁃nisms of imperatorin on regulating P-glycoprotein(P-gp)in blood-brain barrier(BBB)based on net⁃work pharmacology combined with in vitro experi⁃ment.METHODS Drug targets were predicted using ...
关键词：IMPERATORIN blood-brain barrier P-GLYCOPROTEIN network pharmacology in vitro experiment 
Imperatorin alleviates Aβ-induced spatial learning memory impairment and neuroinflam⁃mation in model mice of Alzheimer disease
《中国药理学与毒理学杂志》2021年第9期642-643,共2页WAN Hang-juan LUO Li LIU Xin HE Wei 
OBJECTIVE To investigate the effects of imperatorin on the spatial learning memory impairment and neuroinflammation in model mice of Alzheimer disease(AD)induced by intracerebroventricular injection of Aβ1-42.METHODS...
关键词：IMPERATORIN Alzheimer disease AΒ1-42 learning and memory impairment inflam⁃matory response 
Protective effects of imperatorin against cerebral ischemia/reperfusion-induced oxidative stress through Nrf2 signaling pathway in rats被引量：2
《中国药理学与毒理学杂志》2017年第10期988-988,共1页Wei HE Wei-wei CHEN Xian-hua HUANG Yu-mei ZHOU Fang LIAO 
supported by National Natural Science Foundation of China(81060269 and81360492);Natural Science Foundation of Jiangxi Province of China(20122BAB205036)
OBJECTIVE To investigates the effects of imperatorin on the oxidative stress in the cerebral cortex and hippocampus after focal cerebral ischemia/reperfusion injury.METHODS Transient focal cerebral ischemia/reperfusio...
关键词：IMPERATORIN cerebral ischemia/reperfusion reactive oxygen species nuclear factor erythroid 2-related factor 2 
Effects of Angelica dahurica on obesity and fatty liver in mice被引量：12
《Chinese Journal of Natural Medicines》2016年第9期641-652,共12页LU Xi YUAN Zhi-Yi YAN Xiao-Jin LEI Fan JIANG Jing-Fei YU Xuan YANG Xiu-Wei XING Dong-Ming DU Li-Jun 
supported in part by National Natural Science Foundation of China(Nos.81473321 and 81374006);the National Key Technology R&D Program of China(No.2012BAI29B02);the National S&T Major Special Project for New Drug R&D Program of China(Nos.2012ZX09102-201-008,2012ZX09103-201-041,and 2011ZX09101-002-11)
Angelica dahurica(A. dahurica) is a traditional Chinese medicinal plant being used in clinical practice. The present study demonstrated that A. dahurica could reduce white-fat weight in high-fat-diet hyperlipidemic mi...
关键词：Angelica dahurica IMPERATORIN Hepatic lipases MOUSE 
Estrogenic activity of osthole and imperatorin in MCF-7 cells and their osteoblastic effects in Saos-2 cells被引量：7
《Chinese Journal of Natural Medicines》2016年第6期413-420,共8页JIA Min LI Yuan XIN Hai-Liang HOU Ting-Ting ZHANG Nai-Dai XU Hong-Tao ZHANG Qiao-Yan QIN Lu-Ping 
supported by the National Natural Science Foundation of China(No.81202865)
There is an increasing interest in phytoestrogens due to their potential medical usage in hormone replacement therapy(HRT). The present study was designed to investigate the in vitro effects of estrogen-like activitie...
关键词：OSTHOLE IMPERATORIN MCF-7 Estrogenic activity Estrogen receptors OSTEOBLASTS Alkaline phosphatase 
Aflatoxin B1： Toxicity, bioactivation and detoxification in the polyphagous caterpillar Trichoplusia ni被引量：1
《Insect Science》2013年第3期318-328,共11页Ren Sen Zeng Zhimou Wen Guodong Niu R. Berenbaum 
Trichoplusia ni caterpillars are polyphagous foliage-feeders and rarely likely to encounter aflatoxin B1 （AFB1）, a mycotoxin produced by Aspergillus flavus and A. parasiticus, in their host plants. To determine how ...
关键词：aflatoxin ALLELOCHEMICAL BIOACTIVATION cytochrome P450 monooxygenase flavone Helicoverpa zea IMPERATORIN mycotoxin piperonyl butoxide Trichoplusia ni visnagin XANTHOTOXIN 
An LC-MS/MS Method for Determination of Imperatorin and Isoimperatorin in Rat Plasma and Application to a Pharmacokinetic Study
《Pharmacology & Pharmacy》2013年第5期417-424,共8页Junbo Xing Hong Cao Yumin Chen Caihong Shui Tingting Shan Dan Hu 
A highly sensitive liquid chromatography-tandem mass spectrometric (LC-MS/MS) method was developed for the de-termination of imperatorin and isoimperatorin in rat plasma using psoralen as internal standard. Analyses w...
关键词：IMPERATORIN ISOIMPERATORIN LC-MS/MS PHARMACOKINETIC 
Identification of Herbal Compound Imperatorin with Adverse Effects on ANO1 and CFTR Chloride Channels
《Chemical Research in Chinese Universities》2011年第3期461-463,共3页HAO Feng YI Fei ZHANG Di N1NG Yan SU Wei-heng FENG Xue-chao YANG Hong MA Tong-hui 
Supported by the National Natural Science Foundation of China(Nos.30670477, 30973577 and 30770493);the National Basic Research Program of China(No.2009CB521908)
Calcium-activated chloride channels（CaCCs） are the crucial regulators of transepithelial fluid secretion, smooth muscle contraction and sensory transduction. Recently, compelling evidence has indicated that TMEM16A...
关键词：Calcium-acvtivated chloride channel（CaCC） ANO1 IMPERATORIN Cystic fibrosis transmembrane conductance regulator（CFTR） 
Physicochemical characterization of Baizhi particles by ultrafine pulverization被引量：3
《International Journal of Minerals,Metallurgy and Materials》2011年第2期247-251,共5页Lian-wei Yang Peng Sun Guo-sheng Gai Yu-fen Yang Yu-rong Wang 
supported by the National High-Tech Research and Development Program of China (No.2009AA043202);the Special Project of State Administration of Traditional Chinese Medicine, China (No.200807054)
Baizhi, as a medicinal plant, has been demonstrated to be useful for the treatment of aches and pains in China. The physicochemical characterization of Baizhi particles is greatly influenced by ultrafine pulverization...
关键词：Baizhi physicochemical characterization PULVERIZATION IMPERATORIN EXTRACTION 
Expression of intercellular adhesion molecule-1 in U937 foam cells and inhibitory effect of imperatorin被引量：7
《Acta Pharmacologica Sinica》2002年第4期327-330,共4页杨鹏远 芮耀诚 李凯 黄兴华 蒋建明 余龙 
Project supported by the National Natural Science Foundation of CHina, № 39670832, and also supported by the shanghai-Unilever Research & Development Fund.
AIM: To investigate the expression level of intercellular adhesion molecule-1 (ICAM-1) in a macrophage-derived foam cell model from human U937 cell line and the inhibitory effect of imperatorin (IMP) on the ICAM-1. ME...
关键词：foam cells intercellular adhesion molecule-1 IMPERATORIN LDL lipoprotein Western blotting Northern blotting 
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