BIOACTIVATION

作品数：10被引量：45H指数：3
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相关领域：医药卫生更多>>
相关机构：清华大学更多>>
相关期刊：《Bioactive Materials》《Insect Science》《Journal of Materials Science & Technology》《Science China(Life Sciences)》更多>>
相关基金：国家自然科学基金更多>>
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AP-1 and SP1 trans-activate the expression of hepatic CYP1A1 and CYP2A6 in the bioactivation of AFB1 in chicken
《Science China(Life Sciences)》2024年第7期1468-1478,共11页Jiang Deng Jia-Cheng Yang Yue Feng Ze-Jing Xu Kamil Kuča Meng Liu Lv-Hui Sun 
partly supported by the Chinese Natural Science Foundation Projects(31772636,32072775,32272915);the National Key Research and Development Program of China(2023YFD1301003);the Fundamental Research Funds for the Central Universities(2662023DKPY002);the Top-notch Young Talent Supporting Program to LHS,a gift from Beijing Deyuanshun Biotechnology Co.,Ltd。
Dietary exposure to aflatoxin B1(AFB1)is harmful to the health and performance of domestic animals.The hepatic cytochrome P450s(CYPs),CYP1A1 and CYP2A6,are the primary enzymes responsible for the bioactivation of AFB1...
关键词：aflatoxin B1 CYP1A1 CYP2A6 SP1 AP-1 transcriptional activation 
Artificial tumor microenvironment regulated by first hemorrhage for enhanced tumor targeting and then occlusion for synergistic bioactivation of hypoxia-sensitive platesomes被引量：1
《Acta Pharmaceutica Sinica B》2022年第3期1487-1499,共13页Wenhui Tao Dongyang Zhao Guanting Li Lingxiao Li Songhao Li Hao Ye Chutong Tian Yutong Lu Shuying Li Yinghua Sun Zhonggui He Jin Sun 
financially supported by the National Natural Science Foundation of China(No.81773656);Liaoning Revitalization Talents Program(No.XLYC1808017,China);Shenyang Youth Science and Technology Innovation Talents Program(No.RC190454,China);College Student Innovation and Entrepreneurship Training Program of Shenyang Pharmaceutical University(No.X202010163141,China)。
The unique characteristics of the tumor microenvironment(TME)could be exploited to develop antitumor nanomedicine strategies.However,in many cases,the actual therapeutic effect is far from reaching our expectations du...
关键词：Tumor microenvironment Vascular disrupting agents Biomimetic platesomes PHOTOSENSITIZERS Hypoxia-activated prodrugs Nanomedicine delivery Combination therapy Antitumor and antimetastasis 
Enhanced bioactivity and interfacial bonding strength of Ti3Zr2Sn3Mo25Nb alloy through graded porosity and surface bioactivation被引量：3
《Journal of Materials Science & Technology》2022年第5期137-149,共13页Sen Yu Zhe Yu Dagang Guo Hui Zhu Minghua Zhang Jianye Han Zhentao Yu Yemin Cao Gui Wang 
financial support of the National Natural Science Foundation of China(32071327);National Key Research and Development Program of China(2016YFC1102003);International Science and Technology Cooperation Base of Shaanxi Province(2017GHJD-014);Science and Technology Program of Shaanxi Province(2019GY-200);Key Research and Development Program of Shaanxi Province(2019ZDLSF03-06)。
The gradient porous Ti3Zr2Sn3Mo25Nb(TLM)alloy rods were fabricated through sintering the alloyed powder to a solid core.The porous sample was then modified by a Micro Arc Oxidation(MAO)treatment in an electrolyte cont...
关键词：Graded porosity titanium Secondary microporous Bioactivity Ti3Zr2Sn3Mo25Nb alloy Interface binding strength 
The gut microbiome: an orchestrator of xenobiotic metabolism被引量：19
《Acta Pharmaceutica Sinica B》2020年第1期19-32,共14页Stephanie L.Collins Andrew D.Patterson 
supported by grant ES028288(USA).
Microbes inhabiting the intestinal tract of humans represent a site for xenobiotic metabolism.The gut microbiome,the collection of microorganisms in the gastrointestinal tract,can alter the metabolic outcome of pharma...
关键词：GUT MICROBIOME XENOBIOTIC metabolism Absorption GASTROINTESTINAL TRACT Pharmacokinetics Enterohepatic circulation BIOACTIVATION 
Surface bioactivation of PEEK by neutral atom beam technology被引量：4
《Bioactive Materials》2019年第1期132-141,共10页Joseph Khoury Irina Selezneva Sergei Pestov Vadim Tarassov Artem Ermakov Andrey Mikheev Mikhail Lazov Sean R.Kirkpatrick Dmitry Shashkov Alexandre Smolkov 
partially performed with the financial support of the Ministry of Education and Science of the Russian Federation(RFMEFI57417X0136)。
Polyetheretherketone(PEEK)is an alternative to metallic implants and a material of choice in many applications,including orthopedic,spinal,trauma,and dental.While titanium(Ti)and Ti-alloys are widely used in many intr...
关键词：PEEK NEUTRAL ACTIVATION 
Drug metabolism in drug discovery and development被引量：12
《Acta Pharmaceutica Sinica B》2018年第5期721-732,共12页Zhoupeng Zhang Wei Tang 
Drug metabolism as a discipline plays an important role in drug discovery and development and the effects of drug metabolism on pharmacokinetics(PK), pharmacodynamics(PD), and safety should be carefully considered. Th...
关键词：BIOACTIVATION DRUG discovery and development DRUG metabolism METABOLITE PHARMACOKINETICS PHARMACODYNAMICS Safety TOXICITY 
Bioactivation of titanium dioxide scaffolds by ALP-functionalization被引量：3
《Bioactive Materials》2017年第2期108-115,共8页A.Sengottuvelan P.Balasubramanian J.Will A.R.Boccaccini 
The authors would like to acknowledge Dr.Tobias Fey(University of Erlangen-Nuremberg)for helping with XRD measurements;Mr.Marvin Valley(Institute of Biomaterials,University of Erlangen-Nuremberg)for experimental support.
Three dimensional TiO2 scaffolds are receiving renewed attention for bone tissue engineering (TE) due totheir biocompatibility and attractive mechanical properties. However the bioactivity of these scaffolds iscompara...
关键词：Alkaline phosphatase Titanium dioxide Scaffolds POLYDOPAMINE Surface modification Bioactivity 
Aflatoxin B1： Toxicity, bioactivation and detoxification in the polyphagous caterpillar Trichoplusia ni被引量：1
《Insect Science》2013年第3期318-328,共11页Ren Sen Zeng Zhimou Wen Guodong Niu R. Berenbaum 
Trichoplusia ni caterpillars are polyphagous foliage-feeders and rarely likely to encounter aflatoxin B1 （AFB1）, a mycotoxin produced by Aspergillus flavus and A. parasiticus, in their host plants. To determine how ...
关键词：aflatoxin ALLELOCHEMICAL BIOACTIVATION cytochrome P450 monooxygenase flavone Helicoverpa zea IMPERATORIN mycotoxin piperonyl butoxide Trichoplusia ni visnagin XANTHOTOXIN 
Oxazaphosphorine bioactivation and detoxification: the role of xenobiotic receptors被引量：2
《Acta Pharmaceutica Sinica B》2012年第2期107-117,共11页Duan Wang Hongbing Wang 
supported in part by the National Institute of Health Grant(R01,DK061652);a Seed Grant from University of Maryland Greenebaum Cancer Center。
Oxazaphosphorines,with the most representative members including cyclophosphamide,ifosfamide,and trofosfamide,constitute a class of alkylating agents that have a broad spectrum of anticancer activity against many mali...
关键词：Oxazaphosphorine CYCLOPHOSPHAMIDE IFOSFAMIDE CAR PXR CYP2B6 
LC–MS-based metabolomics in profiling of drug metabolism and bioactivation
《Acta Pharmaceutica Sinica B》2012年第2期118-125,共8页Feng Li Frank JGonzalez Xiaochao Ma 
Since metabolism significantly affects drug safety and efficacy,determining the metabolic profile of a drug is a critical part of drug development.The application of an LC–MS-based metabolomic approach has gained mor...
关键词：Metabolomics Drug metabolism Reactive metabolites Multivariate data analysis 
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