云南高校图书馆联盟文献共享服务平台- XENOBIOTIC

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Atypical functions of xenobiotic receptors in lipid and glucose metabolism: 《Medical Review》2022年第6期611-624,共14页Jingyuan Wang Peipei Lu Wen Xie; supported in part by National Institutes of Health grants DK083952,HD073070,DK099232,ES023438,,ES030429(to W.X.);WX is also supported in part by the Joseph Endowed Professorship from the University of Pittsburgh School of Pharmacy.; Xenobiotic receptors are traditionally defined as xenobiotic chemical-sensing receptors,the activation of which transcriptionally regulates the expression of enzymes and transporters involved in the metabolism and dis...; 关键词：aryl hydrocarbon receptor constitutive androstane receptor lipid metabolism pregnane X receptor xenobiotic receptors

The bio-interactions between plants,insecticides and fertilizers:an innovative approach for the research of xenobiotic substances: 《Natural Products and Bioprospecting》2022年第1期678-684,共7页Frédéric Darriet; In this experiment carried out on Caribbean chili pepper plants(Capsicum chinensis),the bio-insecticide azadirachtin in combination with an NPK fertilizer proved to have a greater lethal impact on the larvae of Aedes ...; 关键词：Chili pepper plant Azadirachtin bio-insecticide NPK fertilizer Capsaicinoid compounds Xenobiotic substance Aedes albopictus Innovative research

Understanding the physiological functions of the host xenobiotic-sensing nuclear receptors PXR and CAR on the gut microbiome using genetically modified mice被引量：6: 《Acta Pharmaceutica Sinica B》2022年第2期801-820,共20页Mallory Little Moumita Dutta Hao Li Adam Matson Xiaojian Shi Gabby Mascarinas Bruk Molla Kris Weigel Haiwei Gu Sridhar Mani Julia Yue Cui; supported by National Institutes of Health(NIH,USA)grant ES025708,ES030197,GM111381,ES031098;the University of Washington Center for Exposures,Diseases,Genomics,and Environment,USA[P30 ES0007033];the Murphy Endowment,USA;The Peer Reviewed Medical Research Program-Investigator Initiated Research Award under Award No.W81XWH-17-1-0479;NIH grants(CA 222469,USA)。; Pharmacological activation of the xenobiotic-sensing nuclear receptors pregnane X receptor(PXR) and constitutive androstane receptor(CAR) is well-known to increase drug metabolism and reduce inflammation. Little is kn...; 关键词：PXR CAR Gut microbiome Bile acids Inflammation Mice Nuclear receptor FECES

Anaerobic degradation of xenobiotic organic contaminants(XOCs):The role of electron flow and potential enhancing strategies被引量：2: 《Journal of Environmental Sciences》2021年第3期397-412,共16页Yijing Li Shanghua Wu Shijie Wang Shijie Zhao Xuliang Zhuang; supported by National Key R&D Program of China(Nos.2019YFC1805803);the National Natural Science Foundation of China(Nos.91951108,41907273 and 31670507);the Strategic Priority Research Program of Chinese Academy of Sciences(No.XDA23010400);Science and Technology Service Network Initiative of the Chinese Academy of Sciences(Grant KFJ-STS-ZDTP-064)。; In groundwater,deep soil layer,sediment,the widespread of xenobiotic organic contaminants(XOCs)have been leading to the concern of human health and eco-environment safety,which calls for a better understanding on the ...; 关键词：Organic contamination Anoxic environment Anaerobic biodegradation Terminal electron acceptor processes(TEAPs)

Numerical Study on Microbial Depolymerization Process of Xenobiotic Polymer: 《Journal of Materials Science and Chemical Engineering》2021年第1期43-50,共8页Masaji Watanabe Fusako Kawai; This study demonstrates mathematical analysis of biodegradation processes of xenobiotic polymers. A model for microbial population is based on the fact that growth rate of microorgani...; 关键词：BIODEGRADATION POLYMER Mathematical Model Inverse Problem Numeri-cal Simulation

Regulation of expression of drug-metabolizing enzymes by oncogenic signaling pathways in liver tumors: a review被引量：5: 《Acta Pharmaceutica Sinica B》2020年第1期113-122,共10页Albert Braeuning Michael Schwarz; Mutations in genes encoding key players in oncogenic signaling pathways trigger specific downstream gene expression profiles in the respective tumor cell populations.While regulation of genes related to cell growth,su...; 关键词：XENOBIOTIC metabolism HEPATOCYTES WNT/b-catenin SIGNALING RAS/MAPK SIGNALING Gene MUTATION CYTOCHROME P450

Long-noncoding RNAs(lncRNAs) in drug metabolism and disposition, implications in cancer chemo-resistance被引量：11: 《Acta Pharmaceutica Sinica B》2020年第1期105-112,共8页Yue Wang Zihui Fang Mei Hong Da Yang Wen Xie; supported in part by NIH grant ES030429(to W.X.)and CA222274(to D.Y.);supported in part by the Joseph Koslow Endowed Professorship from the University of Pittsburgh School of Pharmacy.; Drug metabolism is an orchestrated process in which drugs are metabolized and disposed through a series of specialized enzymes and transporters.Alterations in the expression and/or activity of these enzymes and transp...; 关键词：LncRNA DRUG METABOLISM Chemo-resistance XENOBIOTIC RECEPTOR Regulation

The gut microbiome: an orchestrator of xenobiotic metabolism被引量：19: 《Acta Pharmaceutica Sinica B》2020年第1期19-32,共14页Stephanie L.Collins Andrew D.Patterson; supported by grant ES028288(USA).; Microbes inhabiting the intestinal tract of humans represent a site for xenobiotic metabolism.The gut microbiome,the collection of microorganisms in the gastrointestinal tract,can alter the metabolic outcome of pharma...; 关键词：GUT MICROBIOME XENOBIOTIC metabolism Absorption GASTROINTESTINAL TRACT Pharmacokinetics Enterohepatic circulation BIOACTIVATION

Xenobiotic receptors in mediating the effect of sepsis on drug metabolism被引量：3: 《Acta Pharmaceutica Sinica B》2020年第1期33-41,共9页Chuanzhu Lv Ling Huang; supported by grants from the National Natural Science Foundation of China(8140130969and 8176130232);Hainan Provincial Science and Technology Major Project(ZDKJ201804,China).; Sepsis is an infection-induced systemic inflammatory syndrome.The immune response in sepsis is characterized by the activation of both proinflammatory and anti-inflammatory pathways.When sepsis occurs,the expression a...; 关键词：SEPSIS Inflammatory CYTOKINES XENOBIOTIC RECEPTORS DRUG metabolism Drug-metabolizing ENZYMES DRUG transporters

Mathematical Modeling and Inverse Analysis for Microbial Depolymerization Processes of Xenobiotic Polymers被引量：1: 《Journal of Materials Science and Chemical Engineering》2019年第12期39-46,共8页Masji Watanabe Fusako Kawai; Microbial depolymerization processes of xenobiotic polymers are discussed. A mathematical model is formulated and inverse problems for a time factor and a molecular factor of a degradation rate are described. Experime...; 关键词：MICROBIAL DEPOLYMERIZATION Polyetylene GLYCOL 4000 MATHEMATICAL Model INVERSE Problem Numerical Simulation

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